Driven Spin Systems as Quantum Thermodynamic Machines: Fundamental Limits

We show that coupled two level systems like qubits studied in quantum information can be used as a thermodynamic machine. At least three qubits or spins are necessary and arranged in a chain. The system is interfaced between two split baths and the working spin in the middle is externally driven. The machine performs Carnot-type cycles and is able to work as heat pump or engine depending on the temperature difference of the baths $\Delta T$ and the energy differences in the spin system $\Delta E$. It can be shown that the efficiency is a function of $\Delta T$ and $\Delta E$.Comment: 9 pages, 11 figures, accepted for publication in Phys. Rev.

Global and local relaxation of a spin-chain under exact Schroedinger and master-equation dynamics

We solve the Schroedinger equation for an interacting spin-chain locally coupled to a quantum environment with a specific degeneracy structure. The reduced dynamics of the whole spin-chain as well as of single spins is analyzed. We show, that the total spin-chain relaxes to a thermal equilibrium state independently of the internal interaction strength. In contrast, the asymptotic states of each individual spin are thermal for weak but non-thermal for stronger spin-spin coupling. The transition between both scenarios is found for couplings of the order of $0.1 \times \Delta E$, with $\Delta E$ denoting the Zeeman-splitting. We compare these results with a master equation treatment; when time averaged, both approaches lead to the same asymptotic state and finally with analytical results.Comment: RevTeX, 8 pages, 14 figures, added DOI and forgotten reference

Real-Time-RG Analysis of the Dynamics of the Spin-Boson Model

Using a real-time renormalization group method we determine the complete dynamics of the spin-boson model with ohmic dissipation for coupling strengths $\alpha\lesssim 0.1-0.2$. We calculate the relaxation and dephasing time, the static susceptibility and correlation functions. Our results are consistent with quantum Monte Carlo simulations and the Shiba relation. We present for the first time reliable results for finite cutoff and finite bias in a regime where perturbation theory in $\alpha$ or in tunneling breaks down. Furthermore, an unambigious comparism to results from the Kondo model is achieved.Comment: 4 pages, 5 figures, 1 tabl

Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry

Immunoaffinity enrichment of proteotypic peptides, coupled with selected reaction monitoring, enables indirect protein quantification. However the lack of suitable antibodies limits its widespread application. We developed a method in which multi-specific antibodies are used to enrich groups of peptides, thus facilitating multiplexed quantitative protein assays. We tested this strategy in a pharmacokinetic experiment by targeting a group of homologous drug transforming proteins in human hepatocytes. Our results indicate the generic applicability of this method to any biological system

Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry

Immunoaffinity enrichment of proteotypic peptides, coupled with selected reaction monitoring, enables indirect protein quantification. However the lack of suitable antibodies limits its widespread application. We developed a method in which multi-specific antibodies are used to enrich groups of peptides, thus facilitating multiplexed quantitative protein assays. We tested this strategy in a pharmacokinetic experiment by targeting a group of homologous drug transforming proteins in human hepatocytes. Our results indicate the generic applicability of this method to any biological system

New Class of Eigenstates in Generic Hamiltonian Systems

In mixed systems, besides regular and chaotic states, there are states supported by the chaotic region mainly living in the vicinity of the hierarchy of regular islands. We show that the fraction of these hierarchical states scales as $\hbar^{-\alpha}$ and relate the exponent $\alpha=1-1/\gamma$ to the decay of the classical staying probability $P(t)\sim t^{-\gamma}$. This is numerically confirmed for the kicked rotor by studying the influence of hierarchical states on eigenfunction and level statistics.Comment: 4 pages, 3 figures, Phys. Rev. Lett., to appea

Candidate Gene Sequencing of SLC11A2 and TMPRSS6 in a Family with Severe Anaemia: Common SNPs, Rare Haplotypes, No Causative Mutation

Contains fulltext : 110476.pdf (publisher's version ) (Open Access)BACKGROUND: Iron-refractory iron deficiency anaemia (IRIDA) is a rare disorder which was linked to mutations in two genes (SLC11A2 and TMPRSS6). Common polymorphisms within these genes were associated with serum iron levels. We identified a family of Serbian origin with asymptomatic non-consanguineous parents with three of four children presenting with IRIDA not responding to oral but to intravenous iron supplementation. After excluding all known causes responsible for iron deficiency anaemia we searched for mutations in SLC11A2 and TMPRSS6 that could explain the severe anaemia in these children. METHODOLOGY/RESULTS: We sequenced the exons and exon-intron boundaries of SLC11A2 and TMPRSS6 in all six family members. Thereby, we found seven known and fairly common SNPs, but no new mutation. We then genotyped these seven SNPs in the population-based SAPHIR study (n = 1,726) and performed genetic association analysis on iron and ferritin levels. Only two SNPs, which were top-hits from recent GWAS on iron and ferritin, exhibited an effect on iron and ferritin levels in SAPHIR. Six SAPHIR participants carrying the same TMPRSS6 genotypes and haplotype-pairs as one anaemic son showed lower ferritin and iron levels than the average. One individual exhibiting the joint SLC11A2/TMPRSS6 profile of the anaemic son had iron and ferritin levels lying below the 5(th) percentile of the population's iron and ferritin level distribution. We then checked the genotype constellations in the Nijmegen Biomedical Study (n = 1,832), but the profile of the anaemic son did not occur in this population. CONCLUSIONS: We cannot exclude a gene-gene interaction between SLC11A2 and TMPRSS6, but we can also not confirm it. As in this case candidate gene sequencing did not reveal causative rare mutations, the samples will be subjected to whole exome sequencing

Graphene transistors are insensitive to pH changes in solution

We observe very small gate-voltage shifts in the transfer characteristic of as-prepared graphene field-effect transistors (GFETs) when the pH of the buffer is changed. This observation is in strong contrast to Si-based ion-sensitive FETs. The low gate-shift of a GFET can be further reduced if the graphene surface is covered with a hydrophobic fluorobenzene layer. If a thin Al-oxide layer is applied instead, the opposite happens. This suggests that clean graphene does not sense the chemical potential of protons. A GFET can therefore be used as a reference electrode in an aqueous electrolyte. Our finding sheds light on the large variety of pH-induced gate shifts that have been published for GFETs in the recent literature

Zero-point fluctuations in the ground state of a mesoscopic normal ring

We investigate the persistent current of a ring with an in-line quantum dot capacitively coupled to an external circuit. Of special interest is the magnitude of the persistent current as a function of the external impedance in the zero temperature limit when the only fluctuations in the external circuit are zero-point fluctuations. These are time-dependent fluctuations which polarize the ring-dot structure and we discuss in detail the contribution of displacement currents to the persistent current. We have earlier discussed an exact solution for the persistent current and its fluctuations based on a Bethe ansatz. In this work, we emphasize a physically more intuitive approach using a Langevin description of the external circuit. This approach is limited to weak coupling between the ring and the external circuit. We show that the zero temperature persistent current obtained in this approach is consistent with the persistent current calculated from a Bethe ansatz solution. In the absence of coupling our system is a two level system consisting of the ground state and the first excited state. In the presence of coupling we investigate the projection of the actual state on the ground state and the first exited state of the decoupled ring. With each of these projections we can associate a phase diffusion time. In the zero temperature limit we find that the phase diffusion time of the excited state projection saturates, whereas the phase diffusion time of the ground state projection diverges.Comment: 12 pages, 5 figure

Comparative assessment of clinical rating scales in Wilson’s disease

Background: Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism resulting in multifaceted neurological, hepatic, and psychiatric symptoms. The objective of the study was to comparatively assess two clinical rating scales for WD, the Unified Wilson’s Disease Rating Scale (UWDRS) and the Global Assessment Scale for Wilson’s disease (GAS for WD), and to test the feasibility of the patient reported part of the UWDRS neurological subscale (termed the “minimal UWDRS”). Methods: In this prospective, monocentric, cross-sectional study, 65 patients (median age 35 [range: 15–62] years; 33 female, 32 male) with treated WD were scored according to the two rating scales. Results: The UWDRS neurological subscore correlated with the GAS for WD Tier 2 score (r = 0.80; p < 0.001). Correlations of the UWDRS hepatic subscore and the GAS for WD Tier 1 score with both the Model for End Stage Liver Disease (MELD) score (r = 0.44/r = 0.28; p < 0.001/p = 0.027) and the Child-Pugh score (r = 0.32/r = 0.12; p = 0.015/p = 0.376) were weak. The “minimal UWDRS” score significantly correlated with the UWDRS total score (r = 0.86), the UWDRS neurological subscore (r = 0.89), and the GAS for WD Tier 2 score (r = 0.86). Conclusions: The UWDRS neurological and psychiatric subscales and the GAS for WD Tier 2 score are valuable tools for the clinical assessment of WD patients. The “minimal UWDRS” is a practical prescreening tool outside scientific trials