Universally-composable finite-key analysis for efficient four-intensity decoy-state quantum key distribution

We propose an efficient four-intensity decoy-state BB84 protocol and derive concise security bounds for this protocol with the universally composable finite-key analysis method. Comparing with the efficient three-intensity protocol, we find that our efficient four-intensity protocol can increase the secret key rate by at least $30\%$. Particularly, this increasing rate of secret key rate will be raised as the transmission distance increases. At a large transmission distance, our efficient four-intensity protocol can improve the performance of quantum key distribution profoundly.Comment: accepted by Eur. Phys. J.

SGLT2 inhibitor plus DPP‐4 inhibitor as combination therapy for type 2 diabetes: A systematic review and meta‐analysis

To assess the efficacy and safety of sodium‐glucose co‐transporter 2 (SGLT2) inhibitors plus a dipeptidyl peptidase‐4 (DPP‐4) inhibitor in patients with type 2 diabetes mellitus (T2DM), we performed a systematic review and meta‐analysis of 14 randomized controlled trials (RCTs) involving 4828 patients. Compared with a DPP‐4 inhibitor, SGLT2 inhibitor/DPP‐4 inhibitor combination therapy was significantly associated with a decrease in glycaemic control (HbA1c, −0.71%; fasting plasma glucose [FPG], −25.62 mg/dL; postprandial plasma glucose, −44.00 mg/dL), body weight (−2.05 kg) and systolic blood pressure (−5.90 mm Hg), but an increase in total cholesterol (TC) of 3.24%, high‐density lipoprotein of 6.15% and low‐density lipoprotein of 2.55%. Adding a DPP‐4 inhibitor to an SGLT2 inhibitor could reduce HbA1c by −0.31%, FPG by −8.94 mg/dL, TC by −1.48% and triglycerides by −3.25%. Interestingly, low doses of an SGLT2 inhibitor in the combination has similar or even better efficacy in some aspects than high doses. Similar adverse events were observed for the combination therapy, with the exception of genital infection vs DPP‐4 inhibitor (risk ratio [RR], 5.31) and consistent genital infection vs an SGLT2 inhibitor (RR, 0.61). Further studies are warranted to confirm these results

Twisting the Toll: Electric Vehicles and Information Provision

The transportation sector generates the largest share of greenhouse gas emissions, which concerns governments and communities worldwide. Electric vehicles (EVs) are believed to be the future. Various incentives have been provided to further broaden their acceptance and accelerate their adoption, including toll-exemption programs for EVs. At the same time, an individual’s driving behaviors are largely shaped by navigation applications that provide real-time traffic conditions. In this paper, we aim to understand how information provision affects the optimal structure of the EV-exempt toll. By analyzing a Bayesian routing game, we illustrate the optimality of a non-monotonic tolling strategy as a function of the EV adoption rate. For policymakers, our finding reveals the importance of understanding how the IT-enabled information provision has altered individual drivers\u27 behavior. In addition, the results uncover the general impact of IT, which expands the action space of individuals and the effective regimes of policies

The Mechanisms of Nerve Injury Caused by Viral Infection in the Occurrence of Gastrointestinal Motility Disorder-Related Diseases

Gastrointestinal motility refers to the peristalsis and contractility of gastrointestinal muscles, including the force and frequency of gastrointestinal muscle contraction. Gastrointestinal motility maintains the normal digestive function of the human body and is a critical component of the physiological function of the digestive tract. At present, gastrointestinal motility disorder-related diseases are gradually affecting human production and life. In recent years, it has been consistently reported that the enteric nervous system has a coordinating and controlling role in gastrointestinal motility. Motility disorders are closely related to functional or anatomical changes in the gastrointestinal nervous system. At the same time, some viral infections, such as herpes simplex virus and varicella-zoster virus infections, can cause damage to the gastrointestinal nervous system. Therefore, this paper describes the mechanisms of viral infection in the gastrointestinal nervous system and the associated clinical manifestations. Studies have indicated that the means by which viruses can cause the infection of the enteric nervous system are various, including retrograde transport, hematogenous transmission and centrifugal transmission from the central nervous system. When viruses infect the enteric nervous system, they can cause clinical symptoms, such as abdominal pain, abdominal distension, early satiation, belching, diarrhea, and constipation, by recruiting macrophages, lymphocytes and neutrophils and regulating intestinal microbes. The findings of several case‒control studies suggest that viruses are the cause of some gastrointestinal motility disorders. It is concluded that one of the causes of gastrointestinal motility disorders is viral infection of the enteric nervous system. In such disorders, the relationships between viruses and nerves remain to be studied more deeply. Further studies are necessary to evaluate whether prophylactic antiviral therapy is feasible in gastrointestinal motility disorders

Compressive Property Comparisons Between Laser Engineered Net Shaping of In Situ TiBw-TMCs and Cp-Ti Materials

Titanium (Ti) and its alloys are widely used in chemical, astronautical, and biomedical industries. However, their poor load endurance properties affect their fields of applications especially under severe loading conditions. To enhance these properties, TiBw reinforcement was synthesized by in situ chemical reaction between elemental Ti and boron. Strong interfacial bonding between TiBw reinforcement and Ti matrix was obtained due to the in situ chemical reaction. Owing to its capability of producing difficult-to-machine bulk composites with uniform properties, laser engineered net shaping (LENS) technique was utilized to fabricate TiBw reinforced Ti matrix bulk composites. Few researches have been reported on these three-dimensional metal based bulk composites by using LENS. In this work, effects of TiBw reinforcement and laser power on compressive properties were investigated. The microstructures of the fabricated parts were observed and analyzed by using scanning electron microscopy.Mechanical Engineerin

Genome-wide DNA methylation analysis of pulmonary function in middle and old-aged Chinese monozygotic twins

Background Previous studies have determined the epigenetic association between DNA methylation and pulmonary function among various ethnics, whereas this association is largely unknown in Chinese adults. Thus, we aimed to explore epigenetic relationships between genome-wide DNA methylation levels and pulmonary function among middle-aged Chinese monozygotic twins. Methods The monozygotic twin sample was drawn from the Qingdao Twin Registry. Pulmonary function was measured by three parameters including forced expiratory volume the first second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio. Linear mixed effect model was used to regress the methylation level of CpG sites on pulmonary function. After that, we applied Genomic Regions Enrichment of Annotations Tool (GREAT) to predict the genomic regions enrichment, and used comb-p python library to detect differentially methylated regions (DMRs). Gene expression analysis was conducted to validate the results of differentially methylated analyses. Results We identified 112 CpG sites with the level of P < 1 x 10(-4) which were annotated to 40 genes. We identified 12 common enriched pathways of three pulmonary function parameters. We detected 39 DMRs located at 23 genes, of which PRDM1 was related to decreased pulmonary function, and MPL, LTB4R2, and EPHB3 were related to increased pulmonary function. The gene expression analyses validated DIP2C, ASB2, SLC6A5, and GAS6 related to decreased pulmonary function. Conclusion Our DNA methylation sequencing analysis on identical twins provides new references for the epigenetic regulation on pulmonary function. Several CpG sites, genes, biological pathways and DMRs are considered as possible crucial to pulmonary function.Peer reviewe