Cyclin D1 G870A Polymorphism and Risk of Nasopharyngeal Carcinoma: A Meta-Analysis

Recently, there have been a number of studies on the association between cyclin D1 G870A polymorphism and nasopharyngeal carcinoma risk. However, the results of previous reports remain controversial and ambiguous. Thus, we performed a meta-analysis to explore more precisely the association between cyclin D1 G870A polymorphism and the risk of nasopharyngeal carcinoma. No significant association was found between cyclin D1 G870A polymorphism and nasopharyngeal carcinoma risk in total population analysis. In the subgroup meta-analysis by ethnicity, a negative association was shown in Caucasian subgroup, and no significant association in any genetic models among Asians was observed. In summary, positive results have been shown on the search for polymorphic variants influencing the risk of NPC. This meta-analysis provides evidence of the association between CCND1 G870A polymorphism and NPC risk, supporting the hypothesis that CCND1 870A allele probably acts as an important NPC protective factor in Caucasians but not in Asians. Since the results of our meta-analysis are preliminary and may be biased by the relatively small number of subjects, they still need to be validated by well-designed studies using larger samples in the future

Open Biomedical Ontology-based Medline exploration

Abstract Background Effective Medline database exploration is critical for the understanding of high throughput experimental results and the development of novel hypotheses about the mechanisms underlying the targeted biological processes. While existing solutions enhance Medline exploration through different approaches such as document clustering, network presentations of underlying conceptual relationships and the mapping of search results to MeSH and Gene Ontology trees, we believe the use of multiple ontologies from the Open Biomedical Ontology can greatly help researchers to explore literature from different perspectives as well as to quickly locate the most relevant Medline records for further investigation. Results We developed an ontology-based interactive Medline exploration solution called PubOnto to enable the interactive exploration and filtering of search results through the use of multiple ontologies from the OBO foundry. The PubOnto program is a rich internet application based on the FLEX platform. It contains a number of interactive tools, visualization capabilities, an open service architecture, and a customizable user interface. It is freely accessible at: http://brainarray.mbni.med.umich.edu/brainarray/prototype/pubonto .http://deepblue.lib.umich.edu/bitstream/2027.42/112693/1/12859_2009_Article_3295.pd

Florence-2: Advancing a Unified Representation for a Variety of Vision Tasks

We introduce Florence-2, a novel vision foundation model with a unified, prompt-based representation for a variety of computer vision and vision-language tasks. While existing large vision models excel in transfer learning, they struggle to perform a diversity of tasks with simple instructions, a capability that implies handling the complexity of various spatial hierarchy and semantic granularity. Florence-2 was designed to take text-prompt as task instructions and generate desirable results in text forms, whether it be captioning, object detection, grounding or segmentation. This multi-task learning setup demands large-scale, high-quality annotated data. To this end, we co-developed FLD-5B that consists of 5.4 billion comprehensive visual annotations on 126 million images, using an iterative strategy of automated image annotation and model refinement. We adopted a sequence-to-sequence structure to train Florence-2 to perform versatile and comprehensive vision tasks. Extensive evaluations on numerous tasks demonstrated Florence-2 to be a strong vision foundation model contender with unprecedented zero-shot and fine-tuning capabilities

Evaluation of the Synergy Degree of Watershed Collaborative Governance: A Case Study of Taihu Basin, China

Owing to the publicity and externality of watershed governance, collaborative governance among cities has become an inevitable choice to improve watershed governance performance and promote sustainable development of watersheds. Existing studies have provided many enlightenment on promoting watershed collaborative governance (WCG), while most of them investigated WCG from single or several dimensions with scanty quantitative empirical studies. Against this background, this study aims to establish a comprehensive WCG research framework involving multiple phases and diverse actors to empirically measure the synergy degree of WCG. Specifically, this study constructs a WCG index system composed of resource investment, open cooperation, and performance supervision subsystems that involves actors of government, enterprise, and the public. Using the complex system synergy model, an empirical analysis is performed to evaluate the synergy degree of Taihu Basin collaborative governance among and within cities in Jiangsu province, China during 2014–2020. The results reveal that the Tai Basin collaborative governance among cities was still in the run-in adaptation stage, which was primarily constrained by the discrete open cooperation subsystems among cities. The synergy degree of Taihu Basin collaborative governance within cities presented significant differences. Several targeted implications are proposed according to the results. This study provides a comprehensive index system for synergy degree measurement of WCG and could offer effective guidance for policymakers to design effective strategies for improving WCG performance

Evaluation of the Synergy Degree of Watershed Collaborative Governance: A Case Study of Taihu Basin, China

Owing to the publicity and externality of watershed governance, collaborative governance among cities has become an inevitable choice to improve watershed governance performance and promote sustainable development of watersheds. Existing studies have provided many enlightenment on promoting watershed collaborative governance (WCG), while most of them investigated WCG from single or several dimensions with scanty quantitative empirical studies. Against this background, this study aims to establish a comprehensive WCG research framework involving multiple phases and diverse actors to empirically measure the synergy degree of WCG. Specifically, this study constructs a WCG index system composed of resource investment, open cooperation, and performance supervision subsystems that involves actors of government, enterprise, and the public. Using the complex system synergy model, an empirical analysis is performed to evaluate the synergy degree of Taihu Basin collaborative governance among and within cities in Jiangsu province, China during 2014–2020. The results reveal that the Tai Basin collaborative governance among cities was still in the run-in adaptation stage, which was primarily constrained by the discrete open cooperation subsystems among cities. The synergy degree of Taihu Basin collaborative governance within cities presented significant differences. Several targeted implications are proposed according to the results. This study provides a comprehensive index system for synergy degree measurement of WCG and could offer effective guidance for policymakers to design effective strategies for improving WCG performance

Effects of preparation process on microstructure and properties of porous Ti6Al4V

The forced sweat cooling of porous media is an effective way to solve the problem of thermal protection of the leading edge of hypersonic vehicles. The pore structure and performance of porous media have a significant impact on its cooling effect and reliability. Therefore，it is very important to prepare porous materials that meet the requirements of forced sweat cooling. Herein，Ti6Al4V pre-alloyed powders were used as raw materials，and porous Ti6Al4V samples with different open porosity were prepared by compression molding combined with high-temperature sintering. The effect of the sintering temperature and holding time on the microstructures，phase compositions and mechanical properties of the samples were investigated. The results show that increasing the sintering temperature and prolonging the holding time will reduce the open porosity of the material. When the open porosity is high，the pores in the material are connected and the seepage rate is high，while the sample strength is low. When the open porosity is low，large pores in the sample are reduced and the seepage rate decreases，but the strength becomes higher. The porous Ti6Al4V sample with an open porosity of 21.8% shows the best comprehensive performance. When the porous Ti6Al4V sample is used as active thermal protection material，it can withstand flame ablation with an average heat flux of 2.5 MW/m2