Empirical Modeling for the Spot Price of Gold Based on Influencing Factors

In light of the special roles of the price of gold on the technological and economic development as well as social aspects of human society, it is of great importance and necessity to develop a series of statistical models that, based on sound reflection of the current structure of the gold market, are able to provide valuable references for trends of the gold price. In fact, the gold price is influenced by a variety of economic factors. For forecasting purposes, it is useful to study the short- and long-run effect of direct and indirect economic factors towards the supply and demand of gold and thus the spot price of gold. To this point, this paper focuses on analyzing the individual and mutual impact of influencing factors on the gold price and, simultaneously, providing a short-term forecast of the price of gold based on the relationships with other major macroeconomic variables. While these relationships are modeled with multiple regression, forecasts of individual factors are obtained under multivariate time series models. The forecasting results are found to be accurate in a relative sense, confirming the significant impact of the factors chosen while indicating the validity of the modeling idea applied

Application of Mine Micro-Seismic Monitoring System on Preventing Against Illegal Mining

AbstractThe establishment and application of the Mine Micro-seismic Monitoring System (MMS), provides a powerful method not only to monitor and predict the mine geological hazard, but also to monitor and prevent against the illegal mining. While there was illegal mining, the system can give you the information including the 3-dimensional spatial coordinates in real time.. The monitoring against the illegal mining was aimed at the blast events, so the blast events should be collected and analyzed specially. On the other hand, the energy of the blast events are larger enough to be easily recognized and be 3-d located and then be analyzed by the MMS, and then the satisfied information can be given by the MMS. This kind of usage of the system has been analyzed and confirmed by a practical example

catena-Poly[[[aqua­(1,10-phenan­throline)cadmium(II)]-μ-benzene-1,4-dicarboxyl­ato] benzene-1,4-dicarboxylic acid hemisolvate]

A new cadmium(II) coordination polymer, {[Cd(C8H4O4)(C12H8N2)(H2O)]·0.5C8H6O4}n, has been synthesized under hydro­thermal conditions. The asymmetric unit contains one CdII atom, one benzene-1,4-dicarboxyl­ate anion, one 1,10-phenanthroline ligand, one coordinated water mol­ecule and half of an uncoordinated benzene-1,4-dicaboxylic acid solvent mol­ecule. The CdII atom is in the centre of a monocapped distorted octa­hedron made up of four O atoms of two chelating benzene-1,4-dicarboxyl­ate anions, one water O atom and two 1,10-phenanthroline N atoms. The metal centres are connected via bis-chelating benzene-1,4-dicarboxyl­ate anions into a zigzag chain structure along [001]. These chains are further connected by O—H⋯O hydrogen bonds between the water mol­ecules and adjacent carboxyl­ate O atoms. Additional O—H⋯O hydrogen bonding between the uncoordinated benzene-1,4-dicaboxylic acid mol­ecules along [010] consolidates the structure

Efficient Solution-Phase Synthesis of 4,5,7-Trisubstituted Pyrrolo[3,2- d ]pyrimidines

We have developed an efficient and robust route to synthesize 4,5,7-trisubstituted pyrrolo[3,2-d]pyrimidines as potent kinase inhibitors. This solution-phase synthesis features a SNAr substitution reaction, cross-coupling reaction, one-pot reduction/reductive amination and N-alkylation reaction. These reactions occur rapidly with high yields and have broad substrate scopes. A variety of groups can be selectively introduced into the N5 and C7 positions of 4,5,7-trisubstituted pyrrolopyrimidines at a late stage of the synthesis, thereby providing a highly efficient approach to explore the structure-activity relationships of pyrrolopyrimidine derivatives. Four synthetic analogs have been profiled against a panel of 48 kinases and a new and selective FLT3 inhibitor 9 is identified

Anomalously low ozone of 1997 and 2011 Arctic spring: Monitoring results and analysis

Total ozone observations from the Total Ozone Unit (TOU) aboard the Chinese second generation polar orbiting meteorological satellite, Fengyun-3/A (FY-3/A), revealed that total column ozone over the Arctic declined rapidly from the beginning of March 2011. An extensive region of low column amount formed around mid March; monthly mean total column ozone in March 2011 was about 30% lower than the average observed during 1979—2010. Daily total column density of ozone near the center of low ozone area in mid March was less than 240 Dobson units, about half the total column ozone amount observed during the same period of the prior 10 years. We analyzed total column ozone data from different satellites during 1979—2011. Results show that the Arctic depletion of ozone in spring 2011 was initiated by the cold polar vortex in the lower stratosphere. The March mean total ozone over the Arctic has shown a decreasing trend over the past 32 years, and its variation is strongly correlated with the polar vortex. A similar low ozone process of spring 1997 was compared to that of 2011, but daily variations of total ozone in March over the Northern Hemisphere in 1997 and 2011 have different patterns

Electronic Structure of Transition-Metal Dicyanamides Me[N(CN)2_2]2_2 (Me = Mn, Fe, Co, Ni, Cu)

The electronic structure of Me[N(CN)$_2$]$_2$ (Me=Mn, Fe, Co, Ni, Cu) molecular magnets has been investigated using x-ray emission spectroscopy (XES) and x-ray photoelectron spectroscopy (XPS) as well as theoretical density-functional-based methods. Both theory and experiments show that the top of the valence band is dominated by Me 3d bands, while a strong hybridization between C 2p and N 2p states determines the valence band electronic structure away from the top. The 2p contributions from non-equivalent nitrogen sites have been identified using resonant inelastic x-ray scattering spectroscopy with the excitation energy tuned near the N 1s threshold. The binding energy of the Me 3d bands and the hybridization between N 2p and Me 3d states both increase in going across the row from Me = Mn to Me = Cu. Localization of the Cu 3d states also leads to weak screening of Cu 2p and 3s states, which accounts for shifts in the core 2p and 3s spectra of the transition metal atoms. Calculations indicate that the ground-state magnetic ordering, which varies across the series is largely dependent on the occupation of the metal 3d shell and that structural differences in the superexchange pathways for different compounds play a secondary role.Comment: 20 pages, 11 figures, 2 table

Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors

Abnormal activation or overexpression of Mer receptor tyrosine kinase has been implicated in survival signaling and chemoresistance in many human cancers. Consequently, Mer is a promising novel cancer therapeutic target. A structure-based drug design approach using a pseudo-ring replacement strategy was developed and validated to discover a new family of pyridinepyrimidine analogs as potent Mer inhibitors. Through SAR studies, 10 (UNC2250) was identified as the lead compound for further investigation based on high selectivity against other kinases and good pharmacokinetic properties. When applied to live cells, 10 inhibited steady-state phosphorylation of endogenous Mer with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein. Treatment with 10 also resulted in decreased colony-forming potential in rhabdoid and NSCLC tumor cells, thereby demonstrating functional anti-tumor activity. The results provide a rationale for further investigation of this compound for therapeutic application in patients with cancer

Comprehensive Evaluation of Tea Cultivars Suitable for Matcha Production Using Multivariate Statistical Analysis

Matcha was prepared from 36 tea cultivars grown in the same tea garden according to the shading requirements for fresh leaves to be used for the production of matcha and its 11 quality indexes such as sensory quality, major physicochemical properties and chroma values were analyzed. In order to select tea cultivars suitable for the manufacturing of matcha, a comprehensive evaluation model of matcha quality was established by cluster analysis (CA), principal component analysis (PCA) and multiple linear regression analysis. The CA results showed that the 36 cultivars could be divided into three groups. Matcha from group I had the best quality with green color, fresh and mellow taste, and low phenol/ammonia ratio. Matcha from group II had high phenol/ammonia ratio and strong astringent taste. Matcha from Group III, consisting of etiolated and albino cultivars, had poor color and aroma quality. The PCA results showed that the cumulative contribution rate of the first five principal components was 88.152%. Comprehensive evaluation of matcha using the evaluation function constructed based on the first five principal components showed that the top 10 cultivars were Zhongcha 102, Taicha 12, Zhongcha 108, Fuding Dahao, Meizhan, Fuding Dabai, Fuyun 6, Zi Mudan, Maolv and Yingshuang. The model describing the relationship between sensory quality and physicochemical properties established by multiple linear regression analysis was as follows: y = 3.167|a*| + 46.850 (R2 = 0.710, P < 0.001). The scores of matcha cultivars evaluated by this model were highly consistent with the comprehensive evaluation results based on principal components, indicating that the a* value of dried tea could be used as a representative index to evaluate the quality of matcha. The results of this study can provide a reference for evaluating the suitability of tea cultivars for matcha manufacturing

Discovery of Mer Specific Tyrosine Kinase Inhibitors for the Treatment and Prevention of Thrombosis

The role of Mer kinase in regulating the second phase of platelet activation generates an opportunity to use Mer inhibitors for preventing thrombosis with diminished likelihood for bleeding as compared to current therapies. Toward this end, we have discovered a novel, Mer kinase specific substituted-pyrimidine scaffold using a structure-based drug design and a pseudo-ring replacement strategy. The co-crystal structure of Mer with two compounds (7 & 22) possessing distinct activity have been determined. Subsequent SAR studies identified compound 23 (UNC2881) as a lead compound for in vivo evaluation. When applied to live cells, 23 inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. Treatment with 23 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, 23 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis