Highly efficient blueish-green fluorescent OLEDs based on AIE liquid crystal molecules : From ingenious molecular design to multifunction materials

In order to seek the balance point between liquid crystallinity and high efficiency emission, two novel aggregation-induced emission-based (AIE) liquid crystal materials of TPE-PBN and TPE-2PBN, which contain a tetraphenylethene derivative as the emission core and a 4-cynobiphenyl moiety as the mesogenic unit, were designed and prepared. Both simple molecules showed a mesophase at high temperature as evidenced by polarised optical microscopy (POM), differential scanning calorimetry (DSC) and temperature-dependent X-ray diffraction (XRD). Simultaneously, TPE-PBN and TPE-2PBN presented clear AIE characteristics in the blueish-green region and achieved a high emission quantum efficiency of 71% and 83% in the solid state, respectively. Due to the self-assembly properties of thermotropic liquid crystals, both compounds showed higher hole mobilities in the annealed films than in pristine films. Employing TPE-PBN and TPE-2PBN as the emitting materials, both non-doped devices and doped devices were fabricated. The TPE-PBN-based doped OLEDs showed a better device performance with an external quantum efficiency (EQE) of 4.1% which is among the highest EQEs of blue AIE fluorescent OLEDs

Suspension polymerization casting of lead zirconate titanate, part I: Acrylamide hydrogel system

Suspension polymerization casting of lead zirconate titanate (PZT) filled acrylamide systems was studied. A high solid loading (51 vol%) PZT slurry with low viscosity (about 280 mPa·s at shear rate 10 s −1 ) was obtained by optimizing the dispersant amount. The polymerization process for the monomer solution and PZT slurry were characterized with the help of the storage modulus measurement. For the monomer solution, the overall activation energy of gelation was calculated as 60–76 kJ/mol, while for the PZT slurry, this energy increased to 91 ± 9 kJ/mol. The drying, burnout and sintering processes were also addressed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44771/1/10853_2004_Article_5141969.pd

Blue and Green Phosphorescent Liquid-Crystalline Iridium Complexes with High Hole Mobility

Blue- and green-emitting cyclometalated liquid-crystalline iridium complexes are realized by using a modular strategy based on strongly mesogenic groups attached to an acetylacetonate ancillary ligand. The cyclometalated ligand dictates the photophysical properties of the materials, which are identical to those of the parent complexes. High hole mobilities, up to 0.004 cm2 V-1 s-1, were achieved after thermal annealing, while amorphous materials show hole mobilities of only approximately 10-7-10-6 cm2 V-1 s-1, similar to simple iridium complexes. The design strategy allows the facile preparation of phosphorescent liquid-crystalline complexes with fine-tuned photophysical properties

An overview of phosphorescent metallomesogens based on platinum and iridium

Metal atoms with excellent magnetic, electrical and optical properties that are integrated into liquid crystal molecules-metallomesogens-have attracted much attention from chemists, physicists and engineers and many materials based on e.g. Ag, Pt, Pd, Ir, Ni, Cu and lanthanide ions have been reported. Though several reviews and books have been published on metallomesogens, few refer to their photophysical properties. Additionally, metallomesogens with good emission properties in solution or in neat film are still scarce. Owing to the 100% theoretical internal quantum efficiency, phosphorescent liquid-crystalline materials were developed recently. Here, a brief overview of recent research on such materials based on platinum and iridium complexes including their molecular design and structure-property relationships is reported. It is hoped that this review will stimulate further development of luminescent metallomesogens

Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents

Optically active nanomaterials promise to advance a range of biophotonic techniques through nanoscale optical effects and integration of multiple imaging and therapeutic modalities. Here, we report the development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties. Porphysomes enabled the sensitive visualization of lymphatic systems using photoacoustic tomography. Near-infrared fluorescence generation could be restored on dissociation, creating opportunities for low-background fluorescence imaging. As a result of their organic nature, porphysomes were enzymatically biodegradable and induced minimal acute toxicity in mice with intravenous doses of 1,000 mg kg^(−1). In a similar manner to liposomes, the large aqueous core of porphysomes could be passively or actively loaded. Following systemic administration, porphysomes accumulated in tumours of xenograft-bearing mice and laser irradiation induced photothermal tumour ablation. The optical properties and biocompatibility of porphysomes demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy

cAMP-Dependent Protein Kinase Regulates Desensitization of the Capsaicin Receptor (VR1) by Direct Phosphorylation

AbstractThe capsaicin receptor, VR1 (also known as TRPV1), is a ligand-gated ion channel expressed on nociceptive sensory neurons that responds to noxious thermal and chemical stimuli. Capsaicin responses in sensory neurons exhibit robust potentiation by cAMP-dependent protein kinase (PKA). In this study, we demonstrate that PKA reduces VR1 desensitization and directly phosphorylates VR1. In vitro phosphorylation, phosphopeptide mapping, and protein sequencing of VR1 cytoplasmic domains delineate several candidate PKA phosphorylation sites. Electrophysiological analysis of phosphorylation site mutants clearly pinpoints Ser116 as the residue responsible for PKA-dependent modulation of VR1. Given the significant roles of VR1 and PKA in inflammatory pain hypersensitivity, VR1 phosphorylation at Ser116 by PKA may represent an important molecular mechanism involved in the regulation of VR1 function after tissue injury

Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells

CD4+ T cells differentiate into T helper cell subsets in feedforward manners with synergistic signals from the T cell receptor (TCR), cytokines, and lineage-specific transcription factors. Naive CD4+ T cells avoid spontaneous engagement of feedforward mechanisms but retain a prepared state. T cells lacking the adaptor molecule LAT demonstrate impaired TCR-induced signals yet cause a spontaneous lymphoproliferative T helper 2 (TH2) cell syndrome in mice. Thus, LAT constitutes an unexplained maintenance cue. Here, we demonstrate that tonic signals through LAT constitutively export the repressor HDAC7 from the nucleus of CD4+ T cells. Without such tonic signals, HDAC7 target genes Nur77 and Irf4 are repressed. We reveal that Nur77 suppresses CD4+ T cell proliferation and uncover a suppressive role for Irf4 in TH2 polarization; halving Irf4 gene-dosage leads to increases in GATA3+ and IL-4+ cells. Our studies reveal that naive CD4+ T cells are dynamically tuned by tonic LAT-HDAC7 signals

Liquid-crystalline circularly polarised fluorescent emitters with a high luminescence dissymmetry factor

Chiral liquid-crystalline emitters based on 9,9-dimethyl-10-(4-(phenylsulfonyl)phenyl)-9,10-dihydroacridine and a functionalised binaphthol show smectic liquid crystal phases and circularly polarised blue fluorescence with a high luminescence dissymmetry factor |glum| of 0.13. Solution-processable organic light-emitting diodes (OLEDs) based on the enantiomers were explored

Fabrication and experimental characterization of d31 telescopic piezoelectric actuators

A popular and useful piezoelectric actuator is the stack. Unfortunately with this type of actuation architecture the long lengths normally required to obtain necessary displacements can pose packaging and buckling problems. To overcome these limitations, a new architecture for piezoelectric actuators has been developed called telescopic. The basic design consists of concentric shells interconnected by end-caps which alternate in placement between the two axial ends of the shells. This leads to a linear displacement amplification at the cost of force; yet the force remains at the same magnitude as a stack and significantly higher than bender type architectures. This paper describes the fabrication and experimental characterization of three different telescopic prototypes. The actuator prototypes discussed in this paper mark a definitive step forward in fabrication techniques for complex piezoceramic structures. Materials Systems, Inc. has adapted injection molding for the fabrication of net shape piezoceramic actuators. Injection molding provides several advantages over conventional fabrication techniques, including: high production rate, uniform part dimensions, uniform piezoelectric properties, and reduced fabrication and assembly costs. Acrylate polymerization, developed at the University of Michigan, is similar to gelcasting, but uses a nonaqueous slurry which facilitates the production of large, tall, complex components such as the telescopic actuator, and is ideal for the rapid manufacture of unique or small batch structures. To demonstrate these fabrication processes a five tube telescopic actuator was injection molded along with a very tall three tube actuator that was cast using the acrylate polymerization method. As a benchmark, a third actuator was built from off-the-shelf tubes that were joined with aluminum end-caps. Each prototype's free deflection behavior was experimentally characterized and the results of the testing are presented within this paper.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44767/1/10853_2004_Article_382116.pd

Parallel mutual information estimation for inferring gene regulatory networks on GPUs

<p>Abstract</p> <p>Background</p> <p>Mutual information is a measure of similarity between two variables. It has been widely used in various application domains including computational biology, machine learning, statistics, image processing, and financial computing. Previously used simple histogram based mutual information estimators lack the precision in quality compared to kernel based methods. The recently introduced B-spline function based mutual information estimation method is competitive to the kernel based methods in terms of quality but at a lower computational complexity.</p> <p>Results</p> <p>We present a new approach to accelerate the B-spline function based mutual information estimation algorithm with commodity graphics hardware. To derive an efficient mapping onto this type of architecture, we have used the Compute Unified Device Architecture (CUDA) programming model to design and implement a new parallel algorithm. Our implementation, called CUDA-MI, can achieve speedups of up to 82 using double precision on a single GPU compared to a multi-threaded implementation on a quad-core CPU for large microarray datasets. We have used the results obtained by CUDA-MI to infer gene regulatory networks (GRNs) from microarray data. The comparisons to existing methods including ARACNE and TINGe show that CUDA-MI produces GRNs of higher quality in less time.</p> <p>Conclusions</p> <p>CUDA-MI is publicly available open-source software, written in CUDA and C++ programming languages. It obtains significant speedup over sequential multi-threaded implementation by fully exploiting the compute capability of commonly used CUDA-enabled low-cost GPUs.</p