The influence of neighborhood built environment on school-age children’s outdoor leisure activities and obesity: a case study of Shanghai central city in China

ObjectiveThe aim of this study was to examine the influencing pathways of the neighborhood built environment on children’s outdoor leisure activities and obesity.MethodsA total of 378 elementary school students from 10 schools in central Shanghai were selected by a convenient sampling method for questionnaire survey and accelerometer tracking.Results1) The neighborhood built environment could affect children’s obesity not only through direct effect (β = 0.15, p < 0.05), but also through the mediating effect of outdoor leisure activities (β = 0.19, p < 0.05). 2) For boys, the neighborhood built environment could affect children’s obesity not only through direct effect (β = 0.17, p < 0.05), but also through the mediating effect of outdoor leisure activities (β = 0.26, p < 0.05). For girls, the neighborhood built environment could affect children’s obesity only through the mediating effect of outdoor leisure activities (β = 0.13, p < 0.05).ConclusionThe neighborhood built environment and outdoor leisure activities are important influencing factors in children’s obesity. The neighborhood built environment and outdoor leisure activities could have direct and indirect effects on children’s obesity, while there are gender differences in the influencing pathways of the neighborhood built environment on children’s obesity. This study suggests that improving the neighborhood built environment and promoting outdoor leisure activities in children have important value for influencing children’s obesity

Applicability of the acoustic–electrical joint detection method to identify defects in gas insulated system

Abstract There are many defects in gas‐insulated metal‐enclosed switchgear (GIS) and gas‐insulated transmission lines (GIL) that may cause accidents, such as floating potentials, metal particles, air gaps, and cracks in support insulators. Nevertheless, to‐this‐date, there is no effective method to recognize them to adjust their operation status. Accordingly, this study compared three typical defect models to explore the partial discharge process, and three typical experimental models were established to identify the characteristic parameters of acoustic and electrical information in the development of defects. The research study shows that that as the voltage increases, the partial discharge of free‐metal‐particle defects and air‐gap defects obtained by the pulse‐current method increase gradually. A sudden increase also occurred in the partial discharge of the floating potential defect. The discharge amount of free conductive particles obtained by an ultrahigh‐frequency detection method was distributed symmetrically on both sides of the applied voltage peak, and the other two defects were on one side of the peak and yielded an obvious phase difference. The particle collision signal obtained by the ultrasonic method was obvious, but had no obvious phase relationship with the applied voltage. However, the obtained floating potential defect information had obvious phase differences, and the ultrasonic method was not sensitive to air‐gap defects. The three typical defects can be identified by the combined method more accurately; this provides a theoretical basis and data support for GIS and GIS voltage tests, detection technologies, and online monitoring methods

Mapping the global research landscape and trends of autoimmune encephalitis: A bibliometric analysis

Background: Autoimmune encephalitis (AE) is a neuroautoimmune disease featured by the presence of antibodies targeting neuronal surface, synaptic, or intracellular antigens. An increasing number of articles on its clinical manifestations, treatments, and prognosis have appeared in recent years. The objectives of this study were to summarize this growing body of literature and provide an overview of hotspots and trends in AE research using bibliometric analysis. Methods: We retrieved AE-related articles published between 1999 and 2022 from the Web of Science Core Collection. Using bibliometric websites and software, we analyzed the data of AE research, including details about countries, institutions, authors, references, journals, and keywords. Results: We analyzed 3348 articles, with an average of 32.83 citations per article and an H-index of 141. The USA (1091, 32.587%), China (531, 15.860%), Germany (447, 13.351%), England (266, 7.945%), and Japan (213, 6.362%) had the greatest numbers of publications. The top five institutions by numbers of publications were Oxford (143, 4.271%), the Udice French Research Universities (135, 4.032%), the University of Pennsylvania (135, 4.032%), l’Institut National de la Sante de la Recherche Medicale Inserm (113, 3.375%), and the University of Barcelona (110, 3.286%). The most productive authors were J. Dalmau (98, 2.927%), A. Vincent (65, 2.479%), H. Pruess (64, 1.912%), C. G. Bien (43, 1.284%), and F. Graus (43, 1.284%). “autoimmune encephalitis” was the most frequently used keyword (430), followed by “antibodies” (420), “NMDA receptor encephalitis” (383), and “limbic encephalitis” (368). In recent years, research hotspots have focused on the diagnosis and immunotherapy of NMDAR encephalitis and on limbic encephalitis. Conclusion: Developed Western countries have made significant contributions to this field. China has shown a steady increase in the number of publications in recent years, but the quality and influence of these articles warrant efforts at improvement. Future directions in AE research lie in two key areas: (i) the clinical manifestations, prevalence, and prognosis of AE (enabled by advances in diagnosis); and (ii) the efficacy and safety of targeted, individualized immunotherapy

Lymphoplasma Exchange Improves Myasthenia Gravis Exacerbations: A Retrospective Study in a Chinese Center

BackgroundLymphoplasma exchange (LPE), a technique combining plasma exchange with leukapheresis, is emerging as promising treatment for autoimmune diseases. Data on the efficacy and safety of LPE in myasthenia gravis (MG) therapy are scarce. In this study, we aimed to comprehensively review the clinical efficacy, safety, and immunological characteristics of LPE therapy in MG patients.Study Design and MethodsA Chinese cohort of 276 generalized MG patients in state of exacerbation, including impeding crisis, myasthenia crisis, and preparation for thoracic exsection between January 2014 and December 2020, were evaluated in this study.ResultsA total of 276 patients with a median age of 45.5 ± 16.7 years underwent a total of 635 LPE sessions. Clinical scales of Quantitative Myasthenia Gravis (QMG) scores, Myasthenia Gravis Specific Manual Muscle Testing (MMT) scores, activities of daily living (ADL) scores, and quality of life (QOL) scores were improved during 4 weeks’ follow-up. Adverse effects occurred in 20 out of 276 patients, with 14 patients having one adverse event each. Independent predictive factors for good response to LPE therapy were symptom onset before LPE therapy ≤3 days and age on LPE therapy &amp;lt;50 years of age. LPE decreased the serum levels of antibodies, immunoglobulins, and complements 4 weeks after the first replacement, with decreased levels of interleukin (IL)-17A and interferon (IFN)-γ and increased level of IL-10.ConclusionLPE is an effective treatment for MG patients in state of exacerbation and preparation for thymectomy. Early use of LPE on early-onset MG may have good therapeutic effects. The potential mechanism for LPE is the polarization of cytokines from IL-17A, IFN-γ, into IL-10.</jats:sec