Existence and Uniqueness of Solutions for a Discrete Fractional Mixed Type Sum-Difference Equation Boundary Value Problem

By means of Schauder’s fixed point theorem and contraction mapping principle, we establish the existence and uniqueness of solutions to a boundary value problem for a discrete fractional mixed type sum-difference equation with the nonlinear term dependent on a fractional difference of lower order. Moreover, a suitable choice of a Banach space allows the solutions to be unbounded and two representative examples are presented to illustrate the effectiveness of the main results

Solvability for a Discrete Fractional Three-Point Boundary Value Problem at Resonance

This paper is concerned with the existence of solutions to a discrete three-point boundary value problem at resonance involving the Riemann-Liouville fractional difference of order α∈(0,1]. Under certain suitable nonlinear growth conditions imposed on the nonlinear term, the existence result is established by using the coincidence degree continuation theorem. Additionally, a representative example is presented to illustrate the effectiveness of the main result

HIV/AIDS knowledge in detention in Hunan province, China

BACKGROUND: Injection drug use (IDU) is one of the major modes of HIV transmission in China. Drug use is illegal in China, all identified drug users are registered by Public Security Bureau, and most were sent to detention; most detainees engaged in high risk behaviours. In order to well understand the HIV/AIDS knowledge among detainees, a survey was conducted in different detention settings in Hunan province in 2008 to assess knowledge and attitudes about HIV among detainees and to provide useful information for HIV prevention and intervention strategies in detention centers. METHODS: A cross-sectional survey was conducted in 10 detentions in Hunan province, China, and demographic information along with knowledge and attitude of HIV/AIDS was collected through standardized interviews. Descriptive statistics were used to describe HIV knowledge, attitudes, and education services among detainees. RESULTS: There were 956 detainees interviewed from 10 detention centers. The male to female ratio was 2.24:1. The majority detainees received nine years of compulsory education, accounting for 51.5%. There were nine questions to assess HIV/AIDS knowledge of detainees, and 35.7% of those surveyed answered all nine questions correctly. There were 92.3% (882/956) who consented to be informed about the HIV antibody test results when tested, and 81% (774/956) elected that their family members were also informed. All detention centers had an organized HIV/AIDS education program. CONCLUSION: This study gives us an overview about HIV/AIDS knowledge in detention in Hunan province, and all detention sites in the study provided HIV/AIDS intervention services among detainees that focused on HIV/AIDS knowledge, attitude, and health behaviors

Downregulation of CDKN2A and suppression of cyclin D1 gene expressions in malignant gliomas

<p>Abstract</p> <p>Background</p> <p>Malignant gliomas are the most common in central nervous system cancer. Genome-wide association study identifies that CDKN2A was a susceptibility loci for glioma. The CDKN2A/cyclin-dependent kinase 4, 6/Retinoblastoma protein (Rb) pathway is thought to play a crucial role in malignant gliomas pathogenesis. We have investigated the expression of CDKN2A for potential correlations with malignant gliomas grade and potential role of CDKN2A on malignant gliomas pathogenesis.</p> <p>Methods</p> <p>Tumour tissue samples from 61 patients suffering from malignant gliomas were investigated. The expression levels of CDKN2A were detected using immunohistochemical staining and western blot. Overexpression and knockdown of CDKN2A were performed in human glioma cell lines. Subsequently, colony formation, growth curves and CDKN2A-Cyclin-Rb pathway were analyzed.</p> <p>Results</p> <p>Here we show that a lower expression of CDKN2A and a higher expression of cyclin D1 in the patients with high-grade malignant gliomas than low-grade gliomas, respectively. Moreover, overexpression of CDKN2A inhibits growth of glioma cell lines by suppression of cyclin D1 gene expression.</p> <p>Conclusions</p> <p>Our study suggests that CDKN2A as a malignant gliomas suppressor gene, appears to be useful for predicting behaviour of high-grade malignant gliomas. CDKN2A-Cyclin-Rb pathway plays a key role on malignant gliomas formation and that therapeutic targeting of this pathway may be useful in malignant gliomas treatment.</p

Growth of Human Colorectal Cancer SW1116 Cells Is Inhibited by Cytokine-Induced Killer Cells

Previous reports have suggested that treatment with cytokine-induced killer (CIK) cells may benefit patients with various types of tumor. The aim of this study was to evaluate the antitumor effects of CIK cells against the colorectal cancer line SW1116 in vitro and in vivo. CIK cells were generated routinely from peripheral blood mononuclear cells of healthy human donors, and the number of CD3+CD56+ cells was expanded more than 1300-fold after 14-day culture. At an effector : target cell ratio of 50 : 1, the percentage lysis of SW1116 cells reached 68% in the presence of CIK cells, Experimental mice injected with SW1116 cells subcutaneously were divided randomly into four groups: untreated, 5-fluorouracil (5-FU)-treated, CIK-consecutive treated (injected once/day) and CIK-interval treated (injected once every 5 days). CIK cells were injected abdominally five times in total. Compared with the untreated group, xenograft growth was inhibited greatly by CIK treatment, to nearly the same extent as with 5-FU treatment. We demonstrated that the necrotic area in the tumor xenograft was markedly larger in the CIK-treated groups than in the other groups. These findings suggest that CIK-based immunotherapy may represent an effective choice for patients with colorectal cancer

Flashlight-Net : A Modular Convolutional Neural Network for Motor Imagery EEG Classification

Peer reviewe

Research on dynamic behaviors of wheel loaders with different layout of hydropneumatic suspension

The traditional wheel loader is built without any axle suspension and experiences severe vibration. Three different layouts of hydropneumatic suspension, namely, unconnected strut (UCS), interconnected in roll plane (IC-R) and interconnected in roll and pitch plane (IC-RP), are installed on the wheel loader to improve ride comfort. This study mainly focuses on the damping effect of different layouts of suspensions and investigates whether the suspensions will affect the driving and operation stability of the wheel loader. The multibody model of the wheel loader with hydropneumatic suspension is developed by RecurDyn in co-simulation with MATLAB/Simulink. Detailed analysis was performed as the wheel loader was traveling on a C-class road, turning on a flat road, and scooping and unloading crushed rocks. Results showed that (1) the three layouts of suspensions can greatly reduce the vector sum of weighted acceleration; (2) the UCS suspension affects both the driving and operation stability of the wheel loader, and the IC-R suspension affects the operation stability when the wheel loader scoops and unloads crushed rocks, (3) the IC-RP suspension with anti-roll and anti-pitch functions has little effect on the driving and operation stability of the wheel loader