First-Principles Investigation of Anistropic Hole Mobilities in Organic Semiconductors

We report a simple first-principles-based simulation model (combining quantum mechanics with Marcus−Hush theory) that provides the quantitative structural relationships between angular resolution anisotropic hole mobility and molecular structures and packing. We validate that this model correctly predicts the anisotropic hole mobilities of ruberene, pentacene, tetracene, 5,11-dichlorotetracene (DCT), and hexathiapentacene (HTP), leading to results in good agreement with experiment

Natures of Tcs(2900)T_{cs}(2900) and Tcsˉa(2900)T^a_{c\bar{s}}(2900)

Inspired by the states $T_{cs0}(2900)^0$, $T_{cs1}(2900)^0$, $T^a_{c\bar{s}0}(2900)^{0}$ and $T^a_{c\bar{s}0}(2900)^{++}$ reported by the LHCb Collaboration, we carry out a systematical investigation on the properties of the ground and $P$-wave states $[cs][\bar{u}\bar{d}]$ and $[cu][\bar{s}\bar{d}]$ with various spin, isospin or $U$-spin, and color combinations in a multiquark color flux-tube model. Matching our results with the spin-parity and mass of the states $T_{cs0}(2900)^0$ and $T_{cs1}(2900)^0$, we can describe them as the compact states $[cs][\bar{u}\bar{d}]$ with $I(J^{P})=1(0^+)$ and $0(1^-)$ in the model, respectively. The ground state $T_{cs0}(2900)^0$ is mainly made of strongly overlapped axial-vector $[cs]_{\bar{\mathbf{3}}_c}$ and axial-vector $[\bar{u}\bar{d}]_{\mathbf{3}_c}$. The $P$-wave state $T_{cs1}(2900)^0$ is dominantly consisted of gradually separated scalar or axial vector $[cs]_{\bar{\mathbf{3}}_c}$ and scalar $[\bar{u}\bar{d}]_{\mathbf{3}_c}$ in the shape of a dumbbell. Supposing the states $T^a_{c\bar{s}0}(2900)^{0}$ and $T^a_{c\bar{s}0}(2900)^{++}$ belong to the same isospin triplet, the mass of the state $\left [[cu]_{\bar{\mathbf{3}}_c}[\bar{s}\bar{d}]_ {\mathbf{3}_c}\right ]_{\mathbf{1}_c}$ with symmetrical $U$-spin and $J^P=0^+$ is highly consistent with that of the states $T^a_{c\bar{s}0}(2900)^{0}$ and $T^a_{c\bar{s}0}(2900)^{++}$ in the model. After coupling two color configurations, the state $[cu][\bar{s}\bar{d}]$ is a little lighter than the states $T^a_{c\bar{s}0}(2900)^{0}$ and $T^a_{c\bar{s}0}(2900)^{++}$. In addition, we also discuss the properties of other states in the model.Comment: 8 pages, 4 tables, comments are welcom

Observation of counterflow superfluidity in a two-component Mott insulator

The counterflow superfluidity (CSF) was predicted two decades ago. Counterintuitively, while both components in the CSF have fluidity, their correlated counterflow currents cancel out leading the overall system to an incompressible Mott insulator. However, realizing and identifying the CSF remain challenging due to the request on extreme experimental capabilities in a single setup. Here, we observe the CSF in a binary Bose mixture in optical lattices. We prepare a low-entropy spin-Mott state by conveying and merging two spin-1/2 bosonic atoms at every site and drive it adiabatically to the CSF at $\sim$ 1 nK. Antipair correlations of the CSF are probed though a site- and spin-resolved quantum gas microscope in both real and momentum spaces. These techniques and observations provide accessibility to the symmetry-protected topological quantum matters.Comment: 13 pages, 10 figure

FC Gamma Receptors Promote Antibody-Induced LILRB4 Internalization and Immune Regulation of Monocytic AML

The immune checkpoint leukocyte immunoglobulin-like receptor B4 (LILRB4) is found specifically on the cell surface of acute monocytic leukemia (monocytic AML), an aggressive and common subtype of AML. We have developed a humanized monoclonal IgG1 LILRB4-blocking antibody (h128-3), which improved immune regulation but reduced cell surface expression of LILRB4 in monocytic AML models by 40–60%. Interestingly, most of this effect was neutralized by mutation of the Fc region of the antibody (h128-3/N297A), which prevents interaction with Fc gamma receptors (FcγRs). This suggested that there is FcγR-dependent antigenic modulation underlying h128-3’s effects, a mechanism known to alter the function of antibodies targeting B-cell malignancies. We disrupted the Fc-FcγR interaction pharmacologically and with stable CRISPR-Cas9-mediated genetic knockout of FcγRs in monocytic AML cell lines to investigate the role of FcγR-dependent antigenic modulation in the regulation of LILRB4 by h128-3. When FcγRI is inhibited or removed from the surface of monocytic AML cells, h128-3 cannot optimally perform its blocking function, resulting in activation of the LILRB4 inhibitory receptor and leading to a 15–25% decrease in T-cell-mediated cytotoxicity in vitro. In the absence of FcγRI, scaffolding by FcγRIIa allows h128-3 to maintain LILRB4-blocking function. Here we define a FcγR-dependent antigenic modulation mechanism underlying the function of an immunoreceptor blocking antibody for the first time in myeloid malignancy. This research will facilitate the development of safe, precision-targeted antibody therapeutics in myeloid malignancies with greater potency and efficacy

On the specific status of Scelimena spicupennis and a new record of S. discalis from China with mitochondrial genome characterization (Orthoptera, Tetrigidae)

The genus Scelimena Serville (Orthoptera: Tetrigidae) from China is reviewed. One species, Scelimena spicupennis Zheng & Ou, 2003 (China: Yunnan) is redescribed, and a new record of Scelimena discalis (Hancock, 1915) from China is given. An annotated identification key for Chinese species of the genus Scelimena is provided. Mitochondrial genes of S. spicupennis and S. discalis were sequenced and annotated. The sizes of the two sequenced mitogenomes are 17,552 bp (S. discalis), and 16,069 bp (S. spicupennis), respectively. All of the PCGs started with the typical ATN (ATT, ATC or ATG) or TTG codon and most ended with complete TAA or TAG codon, with the exception of the ND5 gene, which terminated with an incomplete T. The mitochondrial genomes for these two recorded species are provided, and the constructed phylogenetic tree supports their morphological taxonomic classification. The topology of the phylogenetic tree showed that three species of Scelimena were clustered into one branch and formed a monophyletic and a holophyletic group