Diagnosis and Treatment of Comorbidities of Tourette's Syndrome and Bipolar Disorder in A 10-Year-Old Boy

Changes in moods are one of the comorbid psychiatric manifestations that frequently occur in patients with Tourette's syndrome. The assessment of a manic episode in children with Tourette's syndrome is challenging. Furthermore, the treatment of children with comorbid mania and Tourette's syndrome has not been extensively studied. We present a 10-year-old boy who suffered from both Tourette's syndrome and mania, whose symptoms improved after using lithium and risperidone. The child was diagnosed with Tourette's syndrome at 7 years of age when he suffered from tics and experienced his first manic episode. He received monotherapy, including haloperidol, risperidone and aripiprazole, and the response was poor. When the combination of lithium and risperidone was used, the tics and mania subsided. It is important to assess individuals with Tourette's syndrome for associated bipolar disorder. The treatment of children with both disorders is a major clinical issue, and our case may serve as an example for successful treatment strategies

Forward Intensity Model Monitoring Using Multivariate Exponential Weighted Moving Average Scheme

We propose a parameter monitoring method for the forward intensity model – the default probability prediction model of the Credit Research Initiative (CRI). We review the relative statistical process control scheme in the field of engineering. Based on this, we propose a new Multivariate Exponential Weighted Moving Average (MEWMA) scheme to monitor the forward intensity model monthly. This new chart might be applied to identify and diagnose the out-of-control (OC) parameters in real time as the data updating, which reduces the cost of recalculating all parameters and improve the operational and calculational efficiency of the default prediction models in practical application

OCT4B1 Regulates the Cellular Stress Response of Human Dental Pulp Cells with Inflammation

Introduction. Infection and apoptosis are combined triggers for inflammation in dental tissues. Octamer-binding transcription factor 4-B1 (OCT4B1), a novel spliced variant of OCT4 family, could respond to the cellular stress and possess antiapoptotic property. However, its specific role in dental pulpitis remains unknown. Methods. To investigate the effect of OCT4B1 on inflammation of dental pulp cells (DPCs), its expression in inflamed dental pulp tissues and DPCs was examined by in situ hybridization, real-time PCR, and FISH assay. OCT4B1 overexpressed DPCs model was established, confirmed by western blot and immunofluorescence staining, and then stimulated with Lipopolysaccharide (LPS). Apoptotic rate was determined by Hoechst/PI staining and FACS. Cell survival rate was calculated by CCK8 assay. Results. In situ hybridization, real-time PCR, and FISH assay revealed that OCT4B1 was extensively expressed in inflamed dental pulp tissues and DPCs with LPS stimulation. Western blot and immunofluorescence staining showed the expression of OCT4B1 and OCT4B increased after OCT4B1 transfection. Hoechst/PI staining and FACS demonstrated that less red/blue fluorescence was detected and apoptotic percentage decreased (3.45%) after transfection. CCK8 demonstrated that the survival rate of pCDH-OCT4B1-flag cells increased. Conclusions. OCT4B1 plays an essential role in inflammation and apoptosis of DPCs. OCT4B might operate synergistically with OCT4B1 to reduce apoptosis

EFFECT OF WEARABLE FITNESS WATCH ON PHYSICAL ACTIVITY IN SCHOOL CHILDREN WITH OVERWEIGHT

Overweight and obesity in children and adolescents is a significant health problem, and lack of physical activity may be a factor related to obesity. In this study, we explored the wearable fitness watch to monitor the physical activity promoted situation of overweight and obese schoolchildren. Participants were overweight schoolchildren divided into two groups, the study group (n=41) and the control group (n=44). In the control group, the wearable fitness watch only displays the time. In the study group, each week, participants set up the goal, which increases the steps by 10% from baseline steps to reach 10,000 steps. The ANOVA is adopted to analyze the parameters such as the average daily number of steps, moderate to vigorous physical activity (MVPA). The results indicated the study group increase and improved daily walking steps and MVPA accumulation time in 8 weeks. The wearable fitness watch can help to promote the physical activity of overweight children