Pole analysis on the hadron spectroscopy of Λb→J/ΨpK−\Lambda_b\to J/\Psi p K^-

In this paper we study the $J/\Psi p$ spectroscopy in the process of $\Lambda_b\to J/\Psi p K^-$. The final state interactions of coupled channel $J/\Psi p$ ~-~ $\bar{D} \Sigma_c$~-~$\bar{D}^{*} \Sigma_c$ are constructed based on K-matrix with the Chew-Mandelstam function. We build the $\Lambda_b\to J/\Psi p K^-$ amplitude according to the Au-Morgan-Pennington method. The event shape is fitted and the decay width of $\Lambda_b\to J/\Psi p K^-$ is used to constrain the parameters, too. With the amplitudes we extract out the poles and their residues. Our amplitude and pole analysis suggest that the $P_c(4312)$ should be $\bar{D}\Sigma_c$ molecule, the $P_c(4440)$ could be an S-wave compact pentaquark state, and the structure around $P_c(4457)$ is caused by the cusp effect. The future experimental measurement of the decays of $\Lambda_b\to \bar{D}\Sigma_c K^-$ and $\Lambda_b\to \bar{D}^*\Sigma_c K^-$ would further help to study the nature of these resonances.Comment: updated to the published versio

THE EFFECTS OF WHOLE-BODY VIBRATION TRAINING ON DECUPLE JUMP PERFORMANCE IN HANDBALL ATHLETES

To evaluate the effects of whole-body vibration training (WBVT) on decuple jump performance in handball athletes. Sixteen collegiate Level I handball athletes volunteered and divided equally as control group and experimental group (EG). All athletes underwent the same handball specific training, but the EG received additional WBVT (amplitude: 2 mm, frequency: 20 - 40 Hz) three time per week for eight weeks. The decuple jump (DJ) performance was evaluated by the total distance covered in ten single leg long jumps. Single factor ANCOVA was used to examine the differences in each parameter between the groups after training with the pretest values as a covariate. The statistic significance was set at p < .05. Results showed that after 8 weeks WBVT, the EG had significantly improved the total distance of DJ (25.03 ± 1.83 m vs. 26.26 ± 1.65 m, F = 5.45, p < .05). It is concluded that 8 weeks of additional WBVT could improve the decuple jump performance in handball athletes

The role of cytochrome c oxidase subunit Va in non-small cell lung carcinoma cells: association with migration, invasion and prediction of distant metastasis

BACKGROUND: Lung cancer is one of the most lethal malignancies worldwide, but useful biomarkers of lung cancer are still insufficient. The aim of this study is to identify some membrane-bound protein(s) associated with migration and invasion in human non-small cell lung cancer (NSCLC) cells. METHODS: We classified four NSCLC cell lines into high and low migration/invasion groups by Transwell and Matrigel assays. Using two-dimensional gel electrophoresis and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), we identified 10 membrane-associated proteins being significantly overexpressed in the high migration/invasion group. The expression of the target protein in the four NSCLC cell lines was then confirmed by reverse transcription polymerase chain reaction (RT-PCR), western blot and immunostaining. RNA interference technique was applied to observe the influence of the target protein on migration and invasion. Gelatin zymography was also performed to evaluate the activities of matrix metalloproteinase (MMP)-2 and MMP-9. Expression condition of the target protein on surgical specimens was further examined by immunohistochemical staining and the clinicopathologic data were analyzed. RESULTS: We identified a mitochondria-bound protein cytochrome c oxidase subunit Va (COX Va) because of its abundant presence found exclusively in tumorous areas. We also demonstrated that migration and invasion of NSCLC cells decreased substantially after knocking down COX Va by siRNA. Meanwhile, we found a positive correlation between COX Va expression, Bcl-2 expression and activities of MMP-2 and MMP-9 in NSCLC cells. Immunohistochemical staining of surgically resected lung adenocarcinomas in 250 consecutive patients revealed that strong COX Va expression was found in 54.8% (137/250) of patients and correlated positively with the status of lymph node metastasis (P = 0.032). Furthermore, strong COX Va expression was associated with the presence of distant metastasis (P = 0.033). CONCLUSIONS: Our current study showed that COX Va may play a role in migration and invasion of NSCLC cells and can be used as a biomarker to predict aggressiveness of NSCLC

Revealing the Electrophysiological Correlates of Working Memory-Load Effects in Symmetry Span Task With HHT Method

Complex span task is one of the commonly used cognitive tasks to evaluate an individual’s working memory capacity (WMC). It is a dual task consisting of a distractor subtask and a memory subtask. Though multiple studies have utilized complex span tasks, the electrophysiological correlates underlying the encoding and retrieval processes in working memory span task remain uninvestigated. One previous study that assessed electroencephalographic (EEG) measures utilizing complex span task found no significant difference between its working memory loads, a typical index observed in other working memory tasks (e.g., n-back task and digital span task). The following design constructs of the paradigm might have been the reason. (1) The fixed-time limit of the distractor subtask may have hindered the assessment of individual WMC precisely. (2) Employing a linear-system-favoring EEG data analysis method for a non-linear system such as the human brain. In the current study, the participants perform the Raven Advanced Progressive Matrices (RAMP) task on 1 day and the symmetry span (Sspan) task on the other. Prior to the formal Sspan task, the participants were instructed to judge 15 simple symmetry questions as quickly as possible. A participant-specific time-limit is chartered from these symmetry questions. The current study utilizes the Sspan task sequential to a distractor subtask. Instead of the fixed time-limit exercised in the previous study, the distractor subtask of the current study was equipped with the participant-specific time-limit obtained from the symmetry questions. This could provide a precise measure of individual WMC. This study investigates if the complex span task resonates EEG patterns similar to the other working memory tasks in terms of working memory-load by utilizing ensemble empirical mode decomposition (EEMD) of Hilbert-Huang transform (HHT). Prior expectations were to observe a decrement in the P300 component of event-related mode (ERM) and a decrement in the power of alpha and beta band frequency with increasing working memory-load. We observed a significantly higher P300 amplitude for the low-load condition compared to the high-load condition over the circumscribed brain network across F4 and C4 electrodes. Time–frequency analysis revealed a significant difference between the high- and low-load conditions at alpha and beta band over the frontal, central, and parietal channels. The results from our study demonstrate precise differences in EEG data pertaining to varied memory-load differences in the complex span task. Thus, assessing complex span tasks with the HHT-based analysis may aid in achieving a better signal to noise ratio and effect size for the results in working memory EEG studies

Lasing on nonlinear localized waves in curved geometry

The use of geometrical constraints opens many new perspectives in photonics and in fundamental studies of nonlinear waves. By implementing surface structures in vertical cavity surface emitting lasers as manifolds for curved space, we experimentally study the impacts of geometrical constraints on nonlinear wave localization. We observe localized waves pinned to the maximal curvature in an elliptical-ring, and confirm the reduction in the localization length of waves by measuring near and far field patterns, as well as the corresponding dispersion relation. Theoretically, analyses based on a dissipative model with a parabola curve give good agreement remarkably to experimental measurement on the transition from delocalized to localized waves. The introduction of curved geometry allows to control and design lasing modes in the nonlinear regime.Comment: 6 pages, 6 figure

Rate adaptation for 802.11 multiuser mimo networks

In multiuser MIMO (MU-MIMO) networks, the optimal bit rate of a user is highly dynamic and changes from one packet to the next. This breaks traditional bit rate adaptation algorithms, which rely on recent history to predict the best bit rate for the next packet. To address this problem, we introduce TurboRate, a rate adaptation scheme for MU-MIMO LANs. TurboRate shows that clients in a MU-MIMO LAN can adapt their bit rate on a per-packet basis if each client learns two variables: its SNR when it transmits alone to the access point, and the direction along which its signal is received at the AP. TurboRate also shows that each client can compute these two variables passively without exchanging control frames with the access point. A TurboRate client then annotates its packets with these variables to enable other clients to pick the optimal bit rate and transmit concurrently to the AP. A prototype implementation in USRP-N200 shows that traditional rate adaptation does not deliver the gains of MU-MIMO WLANs, and can interact negatively with MU-MIMO, leading to low throughput. In contrast, enabling MU-MIMO with TurboRate provides a mean throughput gain of 1.7x and 2.3x, for 2-antenna and 3-antenna APs respectively.National Science Council (China) (contract No. NSC 100-2221-E-001-005-MY2)National Science Foundation (U.S.) (NSF Grant CNS-1117194

The design of a prospective, randomized, open-labeled study to compare the efficacy of lercanidipine with amlodipine on renal function in hypertensive patients aged at least 55 years (LEADER study)

AbstractBackgroundAlthough all classes of antihypertensive treatment can successfully reduce morbidity and mortality of cardiac pathology, prevention of target organ damages is of great importance beyond blood pressure lowering. Unlike most dihydropyridines, lercanidipine dilates both afferent and the efferent arterioles of nephrons, so it may provide renoprotective effects, which other CCBs may not have. The main purpose of this study is to compare the renoprotective effect of lercanidipine and amlodipine among hypertensive people aged 55years and older with newly diagnosed hypertension or those who were treatment-naïve for one month.MethodsThe study is a prospective, open-labelled, randomized, controlled trial to enrol 232 hypertensive patients aged ≥55 years. Subjects will be randomized into lercanidipine arm (10–20mg/day) and amlodipine arm (5–10mg/day) by 1:1 ratio. The dosage can be up-titrated to 20mg/day (lercanidipine group) and 10mg/day (amlodipine group), respectively, at week 4 or any following visit thereafter. Efficacy and safety data will be collected at week 4, 12 and 24 by evaluating the blood pressure lowering, estimated glomerular filtration rate, creatinine clearance, and urine albumin-creatinine ratio.ConclusionsThe reno-protective effects of new generation of CCBs such as lercanidipine administered to patients with hypertension are not investigated well. After all, this study will bring benefit to older patients who need drugs with both excellent anti-hypertensive and reno-protective efficacy. And the results will be provided for future treatment guideline of elder population in Taiwan