Privacy Preserving Utility Mining: A Survey

In big data era, the collected data usually contains rich information and hidden knowledge. Utility-oriented pattern mining and analytics have shown a powerful ability to explore these ubiquitous data, which may be collected from various fields and applications, such as market basket analysis, retail, click-stream analysis, medical analysis, and bioinformatics. However, analysis of these data with sensitive private information raises privacy concerns. To achieve better trade-off between utility maximizing and privacy preserving, Privacy-Preserving Utility Mining (PPUM) has become a critical issue in recent years. In this paper, we provide a comprehensive overview of PPUM. We first present the background of utility mining, privacy-preserving data mining and PPUM, then introduce the related preliminaries and problem formulation of PPUM, as well as some key evaluation criteria for PPUM. In particular, we present and discuss the current state-of-the-art PPUM algorithms, as well as their advantages and deficiencies in detail. Finally, we highlight and discuss some technical challenges and open directions for future research on PPUM.Comment: 2018 IEEE International Conference on Big Data, 10 page

Intracellular Trafficking Network of Protein Nanocapsules: Endocytosis, Exocytosis and Autophagy

The inner membrane vesicle system is a complex transport system that includes endocytosis, exocytosis and autophagy. However, the details of the intracellular trafficking pathway of nanoparticles in cells have been poorly investigated. Here, we investigate in detail the intracellular trafficking pathway of protein nanocapsules using more than 30 Rab proteins as markers of multiple trafficking vesicles in endocytosis, exocytosis and autophagy. We observed that FITC-labeled protein nanoparticles were internalized by the cells mainly through Arf6-dependent endocytosis and Rab34-mediated micropinocytosis. In addition to this classic pathway: early endosome (EEs)/late endosome (LEs) to lysosome, we identified two novel transport pathways: micropinocytosis (Rab34 positive)-LEs (Rab7 positive)-lysosome pathway and EEs-liposome (Rab18 positive)-lysosome pathway. Moreover, the cells use slow endocytosis recycling pathway (Rab11 and Rab35 positive vesicles) and GLUT4 exocytosis vesicles (Rab8 and Rab10 positive) transport the protein nanocapsules out of the cells. In addition, protein nanoparticles are observed in autophagosomes, which receive protein nanocapsules through multiple endocytosis vesicles. Using autophagy inhibitor to block these transport pathways could prevent the degradation of nanoparticles through lysosomes. Using Rab proteins as vesicle markers to investigation the detail intracellular trafficking of the protein nanocapsules, will provide new targets to interfere the cellular behaver of the nanoparticles, and improve the therapeutic effect of nanomedicine