Description and Realization for a Class of Irrational Transfer Functions

This paper proposes an exact description scheme which is an extension to the well-established frequency distributed model method for a class of irrational transfer functions. The method relaxes the constraints on the zero initial instant by introducing the generalized Laplace transform, which provides a wide range of applicability. With the discretization of continuous frequency band, the infinite dimensional equivalent model is approximated by a finite dimensional one. Finally, a fair comparison to the well-known Charef method is presented, demonstrating its added value with respect to the state of art.Comment: 9 pages, 9 figure

Some fundamental properties on the sampling free nabla Laplace transform

Discrete fractional order systems have attracted more and more attention in recent years. Nabla Laplace transform is an important tool to deal with the problem of nabla discrete fractional order systems, but there is still much room for its development. In this paper, 14 lemmas are listed to conclude the existing properties and 14 theorems are developed to describe the innovative features. On one hand, these properties make the N-transform more effective and efficient. On the other hand, they enrich the discrete fractional order system theor

Analytical calculation of the inverse nabla Laplace transform

The inversion of nabla Laplace transform, corresponding to a causal sequence, is considered. Two classical methods, i.e., residual calculation method and partial fraction method are developed to perform the inverse nabla Laplace transform. For the first method, two alternative formulae are proposed when adopting the poles inside or outside of the contour, respectively. For the second method, a table on the transform pairs of those popular functions is carefully established. Besides illustrating the effectiveness of the developed methods with two illustrative examples, the applicability are further discussed in the fractional order case

Antitumor efficacy of combination of interferon-gamma-inducible protein 10 gene with gemcitabine, a study in murine model

<p>Abstract</p> <p>Background</p> <p>Interferon-γ-inducible protein 10 (IP-10) is a potent inhibitor of tumor angiogenesis. It has been reported that the antiangiogenic therapy combined with chemotherapy has synergistic effects.</p> <p>Methods</p> <p>To elucidate the mechanisms of IP-10 gene combined with a chemotherapy agent, we intramuscularly injected pBLAST-IP-10 expression plasmid combined with gemcitabine into tumor-bearing mice.</p> <p>Results</p> <p>The proliferation of endothelial cells was effectively inhibited by IP-10 combined with gemcitabine <it>in vitro</it>. Treatment with pBLAST-IP-10 twice a week for 4 weeks combined with gemcitabine 10 mg/kg (once a week) resulted in sustained high level of IP-10 protein in serum, inhibition of tumor growth and prolongation of the survival of tumor-bearing mice. Compared with administration of IP-10 plasmid or gemcitabine alone, the angiogenesis in tumors were apparently inhibited, and the numbers of apoptotic cells and lymphocytes in tumor increased in the combination therapy group.</p> <p>Conclusion</p> <p>Our data indicate that the gene therapy of antiangiogenesis by intramuscular delivery of plasmid DNA encoding IP-10 combined with gemcitabine has synergistic effects on tomor by inhibiting the proliferation of endothelail cells, inducing the apoptosis of tumor cells, and recruiting lymphocytes to tumor in murine models. The present findings provided evidence of antitumor effects of genetherapy combined with chemotherapy.</p