Revisit assignments of the new excited Ωc\Omega_c states with QCD sum rules

In this article, we distinguish the contributions of the positive parity and negative parity $\Omega_c$ states, study the masses and pole residues of the 1S, 1P, 2S and 2P $\Omega_c$ states with the spin $J=\frac{1}{2}$ and $\frac{3}{2}$ using the QCD sum rules in a consistent way, and revisit the assignments of the new narrow excited $\Omega_c^0$ states. The predictions support assigning the $\Omega_c(3000)$ to be the 1P $\Omega_c$ state with $J^P={\frac{1}{2}}^-$, assigning the $\Omega_c(3090)$ to be the 1P $\Omega_c$ state with $J^P={\frac{3}{2}}^-$ or the 2S $\Omega_c$ state with $J^P={\frac{1}{2}}^+$, and assigning $\Omega_c(3119)$ to be the 2S $\Omega_c$ state with $J^P={\frac{3}{2}}^+$.Comment: 19 pages, 22 figures. arXiv admin note: text overlap with arXiv:1705.0774

A single chemosensor for multiple analytes: fluorogenic and ratiometric absorbance detection of Zn²⁺, Mg²⁺ and F⁻, and its cell imaging

A simple coumarin based sensor 1 has been synthesized from the condensation reaction of 7-hydroxycoumarin and ethylenediamine via the intermediate 7-hydroxy-8-aldehyde-coumarin. As a multiple analysis sensor, 1 can monitor Zn²⁺ with the fluorescence enhanced at 457 nm, and ratiometric detection at 290 nm, 350 nm and 420 nm in DMF/H₂O (1/4, v/v) medium. Sensor 1 can also monitor Mg²⁺ with the fluorescence enhanced at 430 nm, and ratiometric detection at 290 nm, 370 nm and 430 nm in DMF medium through the interaction of chelation enhance fluorescence (CHEF) with metal ions. Furthermore, 1 also can monitor F⁻ with the fluorescence enhanced at 460 nm, and ratiometric detection at 290 nm and 390 nm in DMF medium simultaneously via hydrogen bonding and deprotonation with F− anion. Spectral titration, isothermal titration calorimetry and mass spectrometry revealed that the sensor formed a 1:1 complex with Mg²⁺, Zn²⁺ or F⁻, with stability constants of 4.5 × 10⁶, 3.4 × 10⁶, 8.0 × 10⁴ M⁻1 respectively. The complexation of the ions by 1 was an exothermic reaction driven by entropy processes. Furthermore, the sensor exhibits good membrane-permeability and was capable of monitoring at the intracellular Zn²⁺ level in living cells

Dimensionality Reduction in Deep Learning for Chest X-Ray Analysis of Lung Cancer

Efficiency of some dimensionality reduction techniques, like lung segmentation, bone shadow exclusion, and t-distributed stochastic neighbor embedding (t-SNE) for exclusion of outliers, is estimated for analysis of chest X-ray (CXR) 2D images by deep learning approach to help radiologists identify marks of lung cancer in CXR. Training and validation of the simple convolutional neural network (CNN) was performed on the open JSRT dataset (dataset #01), the JSRT after bone shadow exclusion - BSE-JSRT (dataset #02), JSRT after lung segmentation (dataset #03), BSE-JSRT after lung segmentation (dataset #04), and segmented BSE-JSRT after exclusion of outliers by t-SNE method (dataset #05). The results demonstrate that the pre-processed dataset obtained after lung segmentation, bone shadow exclusion, and filtering out the outliers by t-SNE (dataset #05) demonstrates the highest training rate and best accuracy in comparison to the other pre-processed datasets.Comment: 6 pages, 14 figure

Study on key technologies of energy-saving and environment-protective pumps

To meet energy-saving and environment-protective purpose, a series of plastic pumps are developed by composite molding. There are four key techniques involved, firstly, plastic hydraulic components with light-weight; secondly, steel barrel as a pump casing and a connection component as well; thirdly, floating impeller strategy where impeller is drifting freely along shaft; and lastly, a self balancing impeller technique which can totally keep axial force balancing. The manufacturing process is energy-saving, and the components can be recycled, which have great potentials for conservation of environment

Current Reversals in a inhomogeneous system with asymmetric unbiased fluctuations

We present a study of transport of a Brownian particle moving in periodic symmetric potential in the presence of asymmetric unbiased fluctuations. The particle is considered to move in a medium with periodic space dependent friction. By tuning the parameters of the system, the direction of current exhibit reversals, both as a function of temperature as well as the amplitude of rocking force. We found that the mutual interplay between the opposite driving factors is the necessary term for current reversals.Comment: 9 pages, 7 figure

CircRNA PDE3B regulates tumorigenicity via the miR-136-5p/MAP3K2 axis of esophageal squamous cell carcinoma

Background. CircRNA has a covalently closed circular conformation and a stable structure. However, the exact role of circRNA in esophageal squamous cell carcinoma (ESCC) remains uncertain. The purpose of this study was to explore the role of hsa_circ_0000277 (circ_PDE3B) in ESCC. Methods. The expression levels of circ_PDE3B, miR-136-5p and mitogen-activated protein kinase kinase kinase 2 (MAP3K2) in ESCC tissues and cells were detected by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot. The proliferation ability of EC9706 and KYSE30 cells was detected by clonal formation, 5-ethynyl-2’-deoxyuridine (EdU) and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-Htetrazolium bromide (MTT) assays. Flow cytometry was used to detect the apoptosis rate of cells. Transwell assay was used to detect the invasion ability of EC9706 and KYSE3 cells. The relationship between miR-136-5p and circ_PDE3B or MAP3K2 was verified by dual-luciferase reporter assay and RNA pull-down, and the effect of circ_PDE3B on tumor growth in vivo was explored through tumor transplantation experiment. Immunohistochemistry (IHC) assay was used to detect MAP3K2 and Ki67 expression in mice tumor tissues. Results. The results showed that circ_PDE3B was highly expressed in ESCC tissues and cells. Downregulated circ_PDE3B expression in ESCC cells significantly reduced cell proliferation, migration and invasion. Circ_PDE3B served as a sponge for miR-136- 5p, and miR-136-5p inhibition reversed the roles of circ_PDE3B knockdown in ESCC cells. MAP3K2 was a direct target of miR-136-5p, and miR-136-5p targeted MAP3K2 to inhibit the malignant behaviors of ESCC cells. Furthermore, circ_PDE3B regulated MAP3K2 expression by sponging miR-136-5p. Importantly, circ_PDE3B knockdown inhibited tumor growth in vivo. Conclusions. In conclusion, circ_PDE3B acted as oncogenic circRNA in ESCC and accelerated ESCC progression by adsorption of miR-136-5p and activation of MAP3K2, supporting circ_PDE3B as a potential therapeutic target for ESCC

A reversible and visible colorimetric/fluorescent chemosensor for Al³⁺+ and F⁻ ions with a Large Stoke's shift

A quinoline-vinyl-dihydroxylphenyl linkage comprising a donor-π-bridge-acceptor structural motif, in which the quinoline serves as an electron-withdrawing core, has been synthesized and used as a fluorescent sensor (2) for the recognition of Al³⁺+ and F⁻ by colorimetry/fluorescence. The sensor 2 exhibited little fluorescence due to excited-state intramolecular proton transfer from the hydroxyl oxygens to the nitrogen of the quinoline moiety. By contrast, on coordination of Al³⁺+ or F⁻, sensor 2 afforded strong fluorescence. A reversible “off–on” optical switching mode has been constructed by sequential inputs from Al³⁺+ and F⁻ ions to the sensor 2 via different excitation and emission wavelengths. ¹H NMR and IR spectroscopic analysis revealed that the Al³⁺+ is coordinated to the quinoline nitrogen and phenolic oxygen atoms, whereas the F⁻ center is only coordinated by two phenolic oxygen atoms