Transcription Factor Crosstalk and Regulatory Networks in Hypopharyngeal Squamous Cell Carcinoma

licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. Received: 2014.03.24; Accepted: 2014.04.18; Published: 2014.06.16 To date, no effective therapeutic treatments have been developed for hypopharyngeal squamous cell carcinoma (HPSCC), a disease that has a five-year survival rate of approximately 31 % because of its late diagnosis and aggressive nature. Despite recent improvements in diagnostic methods, there are no effective measures to prevent or detect HPSCC in an early stage. The goal of the current study was to identify molecular biomarkers and networks that can facilitate the speedy identification of HPSCC patients who could benefit from individualized treatment. Isobaric tags for relative and absolute quantification (iTRAQ) labeling was employed with two-dimensional liquid chromatography-tandem mass spectrometry to identify quantitatively the differentially expressed proteins among three types of HPSCC disease stages. The iTRAQ results were evaluated by literature searches and western blot analysis. For example, FUBP1, one of 412 proteins with significantl

Ultra-Wideband Vertically Polarized Long-Slot Circular Phased Array

An ultra-wideband (UWB) vertically-polarized (VP) long-slot circular phased array with compact size is presented. The design realizes a quasi-magnetic current sheet array. It consists of just one circular array instead of a typical cylindrical system, which employs multiple circular arrays to achieve radiated fields with the same properties. A 16-element array was fabricated and measured to demonstrate its azimuthally invariant radiating capabilities. Measurement results show that the developed array achieves a wider impedance bandwidth, commendable cross-polarization discrimination (XPD), and a significantly more compact design than previously reported systems. In its omnidirectional mode, the array exhibits a 107.07% bandwidth (VSWR ≤ 2.0) with an XPD level better than 19.5 dB. In its directional mode, the array operates over 100% bandwidth with an XPD level better than 20.9 dB. The prototype exhibits exceptional azimuthal out-of-roundness values - better than 1.3 dB in its omnidirectional mode - and scan-invariant radiation with a maximum deviation of only 0.8 dB in its directional mode..University of Technology SydneyImmediate accessThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Effects of the Laser Micromelting Process Parameters on the Preparation of Micron-Sized FeCrAl Coatings on Zr Alloy Surfaces

Laser micromelting (LMM) technology allows for the remelting of pre-positioned coatings on the surface of a specimen to form a metallurgical bond with the substrate material, significantly improving the coating’s film–base bond. However, the high energy input from the laser modification process can cause severe element diffusion, rendering the coating susceptible to deformation and cracking. This can be mitigated by controlling the laser power, scanning speed, and offset of the LMM process. The temperature and stress fields of the samples in the LMM process were analyzed via finite element simulation. The effects of the LMM process parameters on the coating morphology were analyzed in conjunction with experiments. The results indicated that the laser power significantly affected the morphology of the coating after remelting, and a higher scanning speed was more likely to cause the coating to accumulate stress. Additionally, a smaller offset inhibited crack generation. At a laser power of 30 W, a scanning speed of 1200 mm/min, and a scanning spacing of 0.035 mm, the surface of the coating had no obvious defects and was relatively flat, and the adhesion and corrosion resistance were significantly improved. This study provides valuable guidance for improving the preparation of micron-sized protective coatings on Zr alloy surfaces