High-resolution mapping of two large-scale transpressional fault zones in the California Continental Borderland: Santa Cruz-Catalina Ridge and Ferrelo faults

New mapping of two active transpressional fault zones in the California Continental Borderland, the Santa Cruz-Catalina Ridge fault and the Ferrelo fault, was carried out to characterize their geometries, using over 4500 line-km of new multibeam bathymetry data collected in 2010 combined with existing data. Faults identified from seafloor morphology were verified in the subsurface using existing seismic reflection data including single-channel and multichannel seismic profiles compiled over the past three decades. The two fault systems are parallel and are capable of large lateral offsets and reverse slip during earthquakes. The geometry of the fault systems shows evidence of multiple segments that could experience throughgoing rupture over distances exceeding 100 km. Published earthquake hypocenters from regional seismicity studies further define the lateral and depth extent of the historic fault ruptures. Historical and recent focal mechanisms obtained from first-motion and moment tensor studies confirm regional strain partitioning dominated by right slip on major throughgoing faults with reverse-oblique mechanisms on adjacent structures. Transpression on west and northwest trending structures persists as far as 270 km south of the Transverse Ranges; extension persists in the southern Borderland. A logjam model describes the tectonic evolution of crustal blocks bounded by strike-slip and reverse faults which are restrained from northwest displacement by the Transverse Ranges and the southern San Andreas fault big bend. Because of their potential for dip-slip rupture, the faults may also be capable of generating local tsunamis that would impact Southern California coastlines, including populated regions in the Channel Islands

The 11 March 2011 Tohoku tsunami wavefront mapping across offshore Southern California

The 11 March 2011 (M_w = 9.0) Tohoku tsunami was recorded by a temporary array of seafloor pressure gauges deployed off the coast of Southern California, demonstrating how dense array data can illustrate and empirically validate predictions of linear tsunami wave propagation characteristics. A noise cross-correlation method was used to first correct for the pressure gauge instrument phase response. Phase and group travel times were then measured for the first arrival in the pressure gauge tsunami waveforms filtered in narrow bands around 30 periods between 200 and 3000 s. For each period, phase velocities were estimated across the pressure gauge array based on the phase travel time gradient using eikonal tomography. Clear correlation was observed between the phase velocity and long-wavelength bathymetry variations where fast and slow velocities occurred for deep and shallow water regions, respectively. In particular, velocity gradients are pronounced at the Patton Escarpment and near island plateaus due to the abrupt bathymetry change. In the deep open ocean area, clear phase velocity dispersion is observed. Comparison with numerically calculated tsunami waveforms validates the approach and provides an independent measure of the finite-frequency effect on phase velocities at long periods

Tracing the Arguello Submarine Canyon System from Shelf Origins to an Abyssal Sink

The Arguello submarine canyon/channel system extends over 300 km from the continental shelf off Point Arguello and Point Conception in southern California westward onto the oceanic crust of the Pacific plate. In the northernmost reaches where the canyon system originates, all stages in the evolution of seafloor morphologic fluid flow features—from pockmarks to gullies to converging rills—are observed, similar to what has been described for the Ascension slope, north of Monterey Bay. These features appear to be active today and are linked to fluid leakage from the underlying hydrocarbon basin. The channel dissects a continental slope that exhibits features consistent with large-scale mass wasting. Upslope scarps may be the source of the morphological feature at the base of the slope previously referred to as the "Arguello submarine fan," with topographic expressions (e.g., large channel meanders, ridges) that are more consistent with mass transport deposits than with deep-sea fan depositional lobes. The modern canyon crosscuts these deposits and parallels an older, meandering channel/canyon to the west. Modern seismicity along the shelf and slope may have, and potentially still can, trigger landslides on the slope. Seismicity associated with seamount volcanism, past subduction, and Borderland transrotational and extensional processes most likely played a role in stimulating mass wasting. The presence of abundant nearby petroleum suggests that gas venting and hydrate dissociation cannot be ruled out as a triggering mechanism for the slope destabilization occurring today. The canyon/channel continues due south on a path possibly determined by the structural grain of north–south-aligned abyssal hills underlying oceanic basement. At latitude 33deg 18min N, the channel makes a 90deg turn (bend) to the west at the E–W-striking Arguello transform fault wall and develops into a meandering channel system that crosses over abyssal hill crustal fabric. The system ultimately straightens as it continues west before veering north, curving around a thickened crustal bulge at a corner offset in the Arguello fracture zone in complex basement structure, and then finally empties into an 800-m-deep basin depocenter

Anisotropy from SKS splitting across the Pacific-North America plate boundary offshore southern California

SKS arrivals from ocean bottom seismometer (OBS) data from an offshore southern California deployment are analysed for shear wave splitting. The project involved 34 OBSs deployed for 12 months in a region extending up to 500 km west of the coastline into the oceanic Pacific plate. The measurement process consisted of removing the effects of anisotropy using a range of values for splitting fast directions and delay times to minimize energy along the transverse seismometer axis. Computed splitting parameters are unexpectedly similar to onland parameters, exhibiting WSW–ENE fast polarization directions and delays between 0.8 and 1.8 s, even for oceanic plate sites. This is the first SKS splitting study to extend across the entire boundary between the North America and Pacific plates, into the oceanic part of the Pacific plate. The splitting results show that the fast direction of anisotropy on the Pacific plate does not align with absolute plate motion (APM), and they extend the trend of anisotropy in southern California an additional 500 km west, well onto the oceanic Pacific plate. We model the finite strain and anisotropy within the asthenosphere associated with density–buoyancy driven mantle flow and the effects of APM. In the absence of plate motion effects, such buoyancy driven mantle flow would be NE-directed beneath the Pacific plate observations. The best-fit patterns of mantle flow are inferred from the tomography-based models that show primary influences from foundering higher-density zones associated with the history of subduction beneath North America. The new offshore SKS measurements, when combined with measurements onshore within the plate boundary zone, indicate that dramatic lateral variations in density-driven upper-mantle flow are required from offshore California into the plate boundary zone in California and western Basin and Range

Tracing the Arguello Submarine Canyon System from Shelf Origins to an Abyssal Sink

The Arguello submarine canyon/channel system extends over 300 km from the continental shelf off Point Arguello and Point Conception in southern California westward onto the oceanic crust of the Pacific plate. In the northernmost reaches where the canyon system originates, all stages in the evolution of seafloor morphologic fluid flow features—from pockmarks to gullies to converging rills—are observed, similar to what has been described for the Ascension slope, north of Monterey Bay. These features appear to be active today and are linked to fluid leakage from the underlying hydrocarbon basin. The channel dissects a continental slope that exhibits features consistent with large-scale mass wasting. Upslope scarps may be the source of the morphological feature at the base of the slope previously referred to as the "Arguello submarine fan," with topographic expressions (e.g., large channel meanders, ridges) that are more consistent with mass transport deposits than with deep-sea fan depositional lobes. The modern canyon crosscuts these deposits and parallels an older, meandering channel/canyon to the west. Modern seismicity along the shelf and slope may have, and potentially still can, trigger landslides on the slope. Seismicity associated with seamount volcanism, past subduction, and Borderland transrotational and extensional processes most likely played a role in stimulating mass wasting. The presence of abundant nearby petroleum suggests that gas venting and hydrate dissociation cannot be ruled out as a triggering mechanism for the slope destabilization occurring today. The canyon/channel continues due south on a path possibly determined by the structural grain of north–south-aligned abyssal hills underlying oceanic basement. At latitude 33deg 18min N, the channel makes a 90deg turn (bend) to the west at the E–W-striking Arguello transform fault wall and develops into a meandering channel system that crosses over abyssal hill crustal fabric. The system ultimately straightens as it continues west before veering north, curving around a thickened crustal bulge at a corner offset in the Arguello fracture zone in complex basement structure, and then finally empties into an 800-m-deep basin depocenter

Offshore Southern California lithospheric velocity structure from noise cross-correlation functions

A new shear wave velocity model offshore Southern California is presented that images plate boundary deformation including both thickening and thinning of the crustal and mantle lithosphere at the westernmost edge of the North American continent. The Asthenospheric and Lithospheric Broadband Architecture from the California Offshore Region Experiment (ALBACORE) ocean bottom seismometer array, together with 65 stations of the onshore Southern California Seismic Network, is used to measure ambient noise correlation functions and Rayleigh wave dispersion curves which are inverted for 3-D shear wave velocities. The resulting velocity model defines the transition from continental lithosphere to oceanic, illuminating the complex history and deformation in the region. A transition to the present-day strike-slip regime between the Pacific and North American Plates resulted in broad deformation and capture of the now >200 km wide continental shelf. Our velocity model suggests the persistence of the uppermost mantle volcanic processes associated with East Pacific Rise spreading adjacent to the Patton Escarpment, which marks the former subduction of Farallon Plate underneath North America. The most prominent of these seismic structures is a low-velocity anomaly underlying the San Juan Seamount, suggesting ponding of magma at the base of the crust, resulting in thickening and ongoing adjustment of the lithosphere due to the localized loading. The velocity model also provides a robust framework for future earthquake location determinations and ground-shaking simulations for risk estimates

Clinical validation of the in silico prediction of immunogenicity of a human recombinant therapeutic protein

Antibodies elicited by protein therapeutics can cause serious side effects in humans. We studied immunogenicity of a recombinant fusion protein (FPX) consisting of two identical, biologically active, peptides attached to human Fc fragment. EpiMatrix, an in silico epitope-mapping tool, predicted promiscuous T-cell epitope(s) within the 14-amino-acid carboxy-terminal region of the peptide portion of FPX. On administration of FPX in 76 healthy human subjects, 37% developed antibodies after a single injection. A memory T-cell response against the above carboxy-terminus of the peptide was observed in antibody-positive but not in antibody-negative subjects. Promiscuity of the predicted T-cell epitope(s) was confirmed by representation of all common HLA alleles in antibody-positive subjects. As predicted by EpiMatrix, HLA haplotype DRB1*0701/1501 was associated with the highest T-cell and antibody response. In conclusion, in silico prediction can be successfully used to identify Class II restricted T-cell epitopes within therapeutic proteins and predict immunogenicity thereof in humans

Anisotropy from SKS splitting across the Pacific-North America plate boundary offshore southern California

SKS arrivals from ocean bottom seismometer (OBS) data from an offshore southern California deployment are analysed for shear wave splitting. The project involved 34 OBSs deployed for 12 months in a region extending up to 500 km west of the coastline into the oceanic Pacific plate. The measurement process consisted of removing the effects of anisotropy using a range of values for splitting fast directions and delay times to minimize energy along the transverse seismometer axis. Computed splitting parameters are unexpectedly similar to onland parameters, exhibiting WSW–ENE fast polarization directions and delays between 0.8 and 1.8 s, even for oceanic plate sites. This is the first SKS splitting study to extend across the entire boundary between the North America and Pacific plates, into the oceanic part of the Pacific plate. The splitting results show that the fast direction of anisotropy on the Pacific plate does not align with absolute plate motion (APM), and they extend the trend of anisotropy in southern California an additional 500 km west, well onto the oceanic Pacific plate. We model the finite strain and anisotropy within the asthenosphere associated with density–buoyancy driven mantle flow and the effects of APM. In the absence of plate motion effects, such buoyancy driven mantle flow would be NE-directed beneath the Pacific plate observations. The best-fit patterns of mantle flow are inferred from the tomography-based models that show primary influences from foundering higher-density zones associated with the history of subduction beneath North America. The new offshore SKS measurements, when combined with measurements onshore within the plate boundary zone, indicate that dramatic lateral variations in density-driven upper-mantle flow are required from offshore California into the plate boundary zone in California and western Basin and Range

A Selective PMCA Inhibitor Does Not Prolong the Electroolfactogram in Mouse

Within the cilia of vertebrate olfactory receptor neurons, Ca(2+) accumulates during odor transduction. Termination of the odor response requires removal of this Ca(2+), and prior evidence suggests that both Na(+)/Ca(2+) exchange and plasma membrane Ca(2+)-ATPase (PMCA) contribute to this removal.In intact mouse olfactory epithelium, we measured the time course of termination of the odor-induced field potential. Replacement of mucosal Na(+) with Li(+), which reduces the ability of Na(+)/Ca(2+) exchange to expel Ca(2+), prolonged the termination as expected. However, treating the epithelium with the specific PMCA inhibitor caloxin 1b1 caused no significant increase in the time course of response termination.Under these experimental conditions, PMCA does not contribute detectably to the termination of the odor response

Limits of Calcium Clearance by Plasma Membrane Calcium ATPase in Olfactory Cilia

BACKGROUND: In any fine sensory organelle, a small influx of Ca(2+) can quickly elevate cytoplasmic Ca(2+). Mechanisms must exist to clear the ciliary Ca(2+) before it reaches toxic levels. One such organelle has been well studied: the vertebrate olfactory cilium. Recent studies have suggested that clearance from the olfactory cilium is mediated in part by plasma membrane Ca(2+)-ATPase (PMCA). PRINCIPAL FINDINGS: In the present study, electrophysiological assays were devised to monitor cytoplasmic free Ca(2+) in single frog olfactory cilia. Ca(2+) was allowed to enter isolated cilia, either through the detached end or through membrane channels. Intraciliary Ca(2+) was monitored via the activity of ciliary Ca(2+)-gated Cl(-) channels, which are sensitive to free Ca(2+) from about 2 to 10 microM. No significant effect of MgATP on intraciliary free Ca(2+) could be found. Carboxyeosin, which has been used to inhibit PMCA, was found to substantially increase a ciliary transduction current activated by cyclic AMP. This increase was ATP-independent. CONCLUSIONS: Alternative explanations are suggested for two previous experiments taken to support a role for PMCA in ciliary Ca(2+) clearance. It is concluded that PMCA in the cilium plays a very limited role in clearing the micromolar levels of intraciliary Ca(2+) produced during the odor response