Growth of a transplantable lymphoma and its modification in mice infected with the inducing virus.

The growth of a transplantable lymphoma was examined in normal mice and in mice previously infected with the lymphoma-inducing virus (ULV). Normal BALB/c mice respond to a footpad injection of X-irradiated lymphoma cells (ULMC) with popliteal lymph node (PLN) enlargement; mice previously infected with ULV do not. 106 viable ULMC injected into the footpads of ULV-infected mice grew progressively, and the animals died with disseminating malignant lymphoma. In contrast, this dose of cells injected into normal animals evoked strong host responses in the foot and draining lymph node, and no progressive growth of the lymphoma occurred. This increased susceptibility of the ULV-infected animals was also observed when ULMC were injected s.c. into the back or i.m. into the calf muscle, but not after s.c. injection of an unrelated 3-methylcholanthrene-induced sarcoma. Resistance to tumour growth after i.v. injection of ULMC is clearly ineffective, since 10 cells can grow and kill the animal, and in this case no increased susceptibility of ULV-infected animals was observed

Identifying Land Use Options for Networked Māori Owned Land Blocks to Deliver on Collective Aspirations in New Zealand

Māori (the indigenous people of New Zealand) have many opportunities and challenges to realise the potential provided by their whenua (land), wai (water) and tangata (people) to deliver to their goals and aspirations. The challenges are old and new, including environmental constraints, governance, geographic isolation, fragmented land ownership, access to finance, and lack of appropriate skills, knowledge, and networks. Extension programmes aimed at the general primary production sector have failed to attract or retain any or many Māori participants. Landowner to landowner learning built around landowner aspirations along with collective action has the potential to inform an extension approach of relevance to Māori. Shared knowledge and scale can enable the realisation of opportunities from networked primary production assets and people. A programme of work “Māori Agribusiness Extension (MABX)” is being undertaken where clusters, a grouping of Māori-owned land blocks or agribusinesses willing to collaborate or collectivise towards a common goal or agreed outcomes, are formed to enable collective learning to build confidence to implement land use change and support decision making. This paper describes the extension model being used and gives an example of one cluster

Notes from lockdown: A series of reflections on some of the political and cultural impacts of the pandemic

A series of reflections on Covid-19 that looks at: how the pandemic affects processes of bordering and increases the indeterminate grey zones within which so many people are forced to live; the way nurses are presented in the media and the hypocrisy of praising them in a moment of crisis while simultaneously devaluing their work and underpaying them; health inequalities in Newham; the inequalities in the craft sector spotlighted by the pandemic; the relationships between radical neighbourliness and local politics; how perceptions of time have been affected during lockdown - and how 24-7 capitalism may seek to take advantage of this radical reorganisation of time

Analysis of the tumorigenic potential of common marmoset lymphoblastoid cells expressing a constitutively activated c-myc gene.

The respective roles of Epstein-Barr virus (EBV) and c-myc in the pathogenesis of endemic Burkitt's lymphoma (BL) are unclear. In order to help resolve the question whether constitutive expression of the c-myc gene in an EBV-immortalised B cell is sufficient to induce a tumorigenic phenotype, B cells from a common marmoset (Callithrix jacchus) were immortalised with EBV, transfected with a constitutively activated c-myc gene and inoculated into the host animals. Despite the cell line transfected with c-myc displaying enhanced growth characteristics, in vitro and in vivo experiments demonstrated that this was not sufficient to induce a tumorigenic phenotype. This supports our previous findings with EBV-immortalised human B cells transfected with an activated c-myc gene (Hotchin et al., 1990)

One-sided Cauchy-Stieltjes Kernel Families

This paper continues the study of a kernel family which uses the Cauchy-Stieltjes kernel in place of the celebrated exponential kernel of the exponential families theory. We extend the theory to cover generating measures with support that is unbounded on one side. We illustrate the need for such an extension by showing that cubic pseudo-variance functions correspond to free-infinitely divisible laws without the first moment. We also determine the domain of means, advancing the understanding of Cauchy-Stieltjes kernel families also for compactly supported generating measures