Heuristic Spike Sorting Tuner (HSST), a framework to determine optimal parameter selection for a generic spike sorting algorithm

Extracellular microelectrodes frequently record neural activity from more than one neuron in the vicinity of the electrode. The process of labeling each recorded spike waveform with the identity of its source neuron is called spike sorting and is often approached from an abstracted statistical perspective. However, these approaches do not consider neurophysiological realities and may ignore important features that could improve the accuracy of these methods. Further, standard algorithms typically require selection of at least one free parameter, which can have significant effects on the quality of the output. We describe a Heuristic Spike Sorting Tuner (HSST) that determines the optimal choice of the free parameters for a given spike sorting algorithm based on the neurophysiological qualification of unit isolation and signal discrimination. A set of heuristic metrics are used to score the output of a spike sorting algorithm over a range of free parameters resulting in optimal sorting quality. We demonstrate that these metrics can be used to tune parameters in several spike sorting algorithms. The HSST algorithm shows robustness to variations in signal to noise ratio, number and relative size of units per channel. Moreover, the HSST algorithm is computationally efficient, operates unsupervised, and is parallelizable for batch processing

INTERREGIONAL EFFECTS OF REDUCED TIMBER HARVESTS: THE IMPACT OF THE NORTHERN SPOTTED OWL LISTING IN RURAL AND URBAN OREGON

A core-periphery, multiregional, input-output model of western Oregon is used to estimate impacts of periphery timber harvest reductions resulting from listing of an endangered species. Under the most probable scenario, 31,620 total jobs would be lost in the two regions. Fourteen percent of this impact is absorbed in the core (Metro) region. Forty percent of periphery and 80% of Metro jobs lost are from service sectors, a result of important core-periphery trade in central place services. Explicit inclusion of unemployment benefits for displaced workers reduces employment loss estimates by 12% to 14%.Resource /Energy Economics and Policy,

THE ROLE OF AGRICULTURE IN OREGON'S ECONOMIC BASE: FINDINGS FROM A SOCIAL ACCOUNTING MATRIX

Most studies of a state’'s economic base count as “"basic”" only the “"traditional"” exports of goods, federal spending, and business investment. “"Nontraditional”" elements of the economic base (including exports of services, federal transfers to state/local governments and households, and extraregional property income) are typically ignored. We construct a social accounting matrix (SAM) for Oregon and estimate Oregon’'s economic base accounting for both traditional and nontraditional elements. Almost 20% of Oregon’'s jobs depend on extraregional income to households (including government transfers and outside property income), 11% depend on lumber and wood and paper products, and 8% depend on agriculture.Agribusiness,

Nonlinearities and Parametric Amplification in Superconducting Coplanar Waveguide Resonators

Experimental investigations of the nonlinear properties of superconducting niobium coplanar waveguide resonators are reported. The nonlinearity due to a current dependent kinetic inductance of the center conductor is strong enough to realize bifurcation of the nonlinear oscillator. When driven with two frequencies near the threshold for bifurcation, parametric amplification with a gain of +22.4 dB is observed.Comment: 4 pages, 5 figures, 1 table. In version 2: Added appendix with model description and fits to measurements. Minor corrections and rephrasin

Incorporating Uncertainties in Atomic Data Into the Analysis of Solar and Stellar Observations: A Case Study in Fe XIII

Information about the physical properties of astrophysical objects cannot be measured directly but is inferred by interpreting spectroscopic observations in the context of atomic physics calculations. Ratios of emission lines, for example, can be used to infer the electron density of the emitting plasma. Similarly, the relative intensities of emission lines formed over a wide range of temperatures yield information on the temperature structure. A critical component of this analysis is understanding how uncertainties in the underlying atomic physics propagates to the uncertainties in the inferred plasma parameters. At present, however, atomic physics databases do not include uncertainties on the atomic parameters and there is no established methodology for using them even if they did. In this paper we develop simple models for the uncertainties in the collision strengths and decay rates for Fe XIII and apply them to the interpretation of density sensitive lines observed with the EUV Imagining spectrometer (EIS) on Hinode. We incorporate these uncertainties in a Bayesian framework. We consider both a pragmatic Bayesian method where the atomic physics information is unaffected by the observed data, and a fully Bayesian method where the data can be used to probe the physics. The former generally increases the uncertainty in the inferred density by about a factor of 5 compared with models that incorporate only statistical uncertainties. The latter reduces the uncertainties on the inferred densities, but identifies areas of possible systematic problems with either the atomic physics or the observed intensities.Comment: in press at Ap

‘No touch’ technologies for environmental decontamination: focus on ultraviolet devices and hydrogen peroxide systems

PURPOSE OF REVIEW: This article reviews 'no touch' methods for disinfection of the contaminated surface environment of hospitalized patients' rooms. The focus is on studies that assessed the effectiveness of ultraviolet (UV) light devices, hydrogen peroxide systems, and self-disinfecting surfaces to reduce healthcare-associated infections (HAIs). RECENT FINDINGS: The contaminated surface environment in hospitals plays an important role in the transmission of several key nosocomial pathogens including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus spp., Clostridium difficile, Acinetobacter spp., and norovirus. Multiple clinical trials have now demonstrated the effectiveness of UV light devices and hydrogen peroxide systems to reduce HAIs. A limited number of studies have suggested that 'self-disinfecting' surfaces may also decrease HAIs. SUMMARY: Many studies have demonstrated that terminal cleaning and disinfection with germicides is often inadequate and leaves environmental surfaces contaminated with important nosocomial pathogens. 'No touch' methods of room decontamination (i.e., UV devices and hydrogen peroxide systems) have been demonstrated to reduce key nosocomial pathogens on inoculated test surfaces and on environmental surfaces in actual patient rooms. Further UV devices and hydrogen peroxide systems have been demonstrated to reduce HAI. A validated 'no touch' device or system should be used for terminal room disinfection following discharge of patients on contact precautions. The use of a 'self-disinfecting' surface to reduce HAI has not been convincingly demonstrated

Healthcare Outbreaks Associated With a Water Reservoir and Infection Prevention Strategies

Hospital water may serve as a reservoir of healthcare-associated pathogens, and contaminated water can lead to outbreaks and severe infections. The clinical features of waterborne outbreaks and infections as well as prevention strategies and control measures are reviewed. The common waterborne pathogens were bacteria, including Legionella and other Gram-negative bacteria, and nontuberculous mycobacteria, although fungi and viruses were occasionally described. These pathogens caused a variety of infections, including bacteremia, invasive and disseminated diseases, particularly among immunocompromised hosts and critically ill adults as well as neonates. Waterborne outbreaks occurred in healthcare settings with emergence of new reported reservoirs, including electronic faucets (Pseudomonas aeruginosa and Legionella), decorative water wall fountains (Legionella), and heater-cooler devices used in cardiac surgery (Mycobacterium chimaera). Advanced molecular techniques are useful for achieving a better understanding of reservoirs and transmission pathways of waterborne pathogens. Developing prevention strategies based on water reservoirs provides a practical approach for healthcare personnel

What Makes Agricultural Intensification Profitable for Mozambican Smallholders? An Appraisal of the Inputs Subsector and the 1996/97 DNER/SG2000 Program

This report summarizes an appraisal of input utilization and marketing in Mozambique, focusing on the following research questions: (1) What are current smallholder yields for major commodities, and what is the potential for increasing yields through the use of improved technologies? (2) To what extent are improved technologies already being used by smallholders, and is the use of improved technologies profitable? (3) How are improved seeds, fertilizer and pesticides currently produced and distributed? and (4) What are the key constraints and opportunities for increasing the use of improved technologies by smallholders?food security, food policy, improved technologies, Farm Management, Downloads July 2008-July 2009: 9, O31,