Limited Lifespan of Fragile Regions in Mammalian Evolution

An important question in genome evolution is whether there exist fragile regions (rearrangement hotspots) where chromosomal rearrangements are happening over and over again. Although nearly all recent studies supported the existence of fragile regions in mammalian genomes, the most comprehensive phylogenomic study of mammals (Ma et al. (2006) Genome Research 16, 1557-1565) raised some doubts about their existence. We demonstrate that fragile regions are subject to a "birth and death" process, implying that fragility has limited evolutionary lifespan. This finding implies that fragile regions migrate to different locations in different mammals, explaining why there exist only a few chromosomal breakpoints shared between different lineages. The birth and death of fragile regions phenomenon reinforces the hypothesis that rearrangements are promoted by matching segmental duplications and suggests putative locations of the currently active fragile regions in the human genome

Automated Detection of EUV Polar Coronal Holes During Solar Cycle 23

A new method for automated detection of polar coronal holes is presented. This method, called perimeter tracing, uses a series of 171, 195, and 304 \AA\ full disk images from the Extreme ultraviolet Imaging Telescope (EIT) on SOHO over solar cycle 23 to measure the perimeter of polar coronal holes as they appear on the limbs. Perimeter tracing minimizes line-of-sight obscurations caused by the emitting plasma of the various wavelengths by taking measurements at the solar limb. Perimeter tracing also allows for the polar rotation period to emerge organically from the data as 33 days. We have called this the Harvey rotation rate and count Harvey rotations starting 4 January 1900. From the measured perimeter, we are then able to fit a curve to the data and derive an area within the line of best fit. We observe the area of the northern polar hole area in 1996, at the beginning of solar cycle 23, to be about 4.2% of the total solar surface area and about 3.6% in 2007. The area of the southern polar hole is observed to be about 4.0% in 1996 and about 3.4% in 2007. Thus, both the north and south polar hole areas are no more than 15% smaller now than they were at the beginning of cycle 23. This compares to the polar magnetic field measured to be about 40% less now than it was a cycle ago.Comment: 18 pagers, 7 figures, accepted to Solar Physic

Transnational partisanship: idea and practice

That parties might successfully organize transnationally is an idea often met with scepticism. This article argues that while certain favourable conditions are indeed absent in the transnational domain, this implies not that partisanship is impossible but that it is likely to be marked by certain traits. Specifically, it will tend to be episodic, structured as a low-density network and delocalized in its ideational content. These tendencies affect the normative expectations one can attach to it. Transnational partisanship should be valued as a transitional phenomenon, e.g. as a pathway to transnational democracy, more than as a desirable thing in itself

Properties of the Top Quark

The top quark was discoverd at the CDF and D0 experiments in 1995. As the partner of the bottom quark its properties within the Standard Model are fully defined. Only the mass is a free parameter. The measurement of the top quark mass and the verification of the expected properties have been an important topic of experimental top quark physics since. In this review the recent results on top quark properties obtained by the Tevatron experiments CDF and D0 are summarised. At the advent of the LHC special emphasis is given to the basic measurement methods and the dominating systematic uncertainties.Comment: Habilitation thesis, revised and updated for publication in EPJ