Studies on the beta-Adrenergic Receptor of Sheep Adipose Tissue

The beta-adrenergic receptor of sheep adipose tissue was studied in adipose tissue membranes and partially-purified preparations, to determine some of its basic structural and pharmacological properties. The work in sheep was complemented with studies on the beta-adrenergic receptor of rat adipocytes, to compare the beta-receptors in these two species. The key findings of the study can be summarised as follows

Cost accounting manual for refrigerated warehouses

Originally published by: Touche, Ross, Bailey & Smart

The VW Diesel Scandal: Engaging Students via Case Research, Analysis, Writing, and Presentation of Findings

A research project involving faculty, staff, students, and the business community was undertaken to investigate and report upon the current status of one of the most egregious scandals in automotive history. A research team consisting of four faculty members and four undergraduate students uncovered and reported the details surrounding the Volkswagen (VW) diesel scandal, and provided recommendations for how VW could regain its stature as the world’s largest automobile manufacturer. The team presented its findings and recommendations in a variety of formats and settings including written cases and case presentations

Divergent cytotoxic and metabolically stimulative functions of sigma-2 receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives

© 2019 by the authors. Astragalus is a very interesting plant genus, well-known for its content of flavonoids, triterpenes and polysaccharides. Its secondary metabolites are described as biologically active compounds showing several activities, e.g., immunomodulating, antibacterial, antiviral and hepatoprotective. This inspired us to analyze the Bulgarian endemic A. aitosensis (Ivanisch.) to obtain deeper information about its phenolic components. We used extensive chromatographic separation of A. aitosensis extract to obtain seven phenolic compounds (1–7), which were identified using combined LC-MS and NMR spectral studies. The 1D and 2D NMR analyses and HR-MS allowed us to resolve the structures of known compounds 5–7 as isorhamnetin-3-O-robinobioside, isorhamnetin-3-O-(2,6-di-O-α-rhamno-pyranosyl-β-galactopyranoside), and alangiflavoside, respectively, and further comparison of these spectral data with available literature helped us with structural analysis of newly described flavonoid glycosides 1–4. These were described in plant source for the first time

Early Australian Optical and Radio Observations of Centaurus A

The discoveries of the radio source Centaurus A and its optical counterpart NGC 5128 were important landmarks in the history of Australian astronomy. NGC 5128 was first observed in August 1826 by James Dunlop during a survey of southern objects at the Parramatta Observatory, west of the settlement at Sydney Cove. The observatory had been founded a few years earlier by Thomas Brisbane, the new governor of the British colony of New South Wales. Just over 120 years later, John Bolton, Gordon Stanley and Bruce Slee discovered the radio source Centaurus A at the Dover Heights field station in Sydney, operated by CSIRO's Radiophysics Laboratory (the forerunner of the Australia Telescope National Facility). This paper will describe this early historical work and summarise further studies of Centaurus A by other Radiophysics groups up to 1960.Comment: 45 pages, 43 figure

Impact of Home Visit Capacity on Genetic Association Studies of Late-Onset Alzheimer\u27s Disease

INTRODUCTION—Findings for genetic correlates of late-onset Alzheimer\u27s disease (LOAD) in studies that rely solely on clinic visits may differ from those with capacity to follow participants unable to attend clinic visits. METHODS—We evaluated previously identified LOAD-risk single nucleotide variants in the prospective Adult Changes in Thought study, comparing hazard ratios (HRs) estimated using the full data set of both in-home and clinic visits (n = 1697) to HRs estimated using only data that were obtained from clinic visits (n = 1308). Models were adjusted for age, sex, principal components to account for ancestry, and additional health indicators. RESULTS—LOAD associations nominally differed for 4 of 21 variants; CR1 and APOE variants were significant after Bonferroni correction. DISCUSSION—Estimates of genetic associations may differ for studies limited to clinic-only designs. Home visit capacity should be explored as a possible source of heterogeneity and potential bias in genetic studies

Recent Advances in RecBole: Extensions with more Practical Considerations

RecBole has recently attracted increasing attention from the research community. As the increase of the number of users, we have received a number of suggestions and update requests. This motivates us to make some significant improvements on our library, so as to meet the user requirements and contribute to the research community. In order to show the recent update in RecBole, we write this technical report to introduce our latest improvements on RecBole. In general, we focus on the flexibility and efficiency of RecBole in the past few months. More specifically, we have four development targets: (1) more flexible data processing, (2) more efficient model training, (3) more reproducible configurations, and (4) more comprehensive user documentation. Readers can download the above updates at: https://github.com/RUCAIBox/RecBole.Comment: 5 pages, 3 figures, 3 table

Proceedings from the Fourth International Symposium on sigma-2 receptors: Role in health and disease

The sigma-2 receptor (S2R) complex has been implicated in central nervous system disorders ranging from anxiety and depression to neurodegenerative disorders such as Alzheimer\u27s disease (AD). The proteins comprising the S2R complex impact processes including autophagy, cholesterol synthesis, progesterone signaling, lipid membrane-bound protein trafficking, and receptor stabilization at the cell surface. While there has been much progress in understanding the role of S2R in cellular processes and its potential therapeutic value, a great deal remains unknown. Th

[D-Ala2,(F5)Phe4]-dynorphin1-13-NH2 (DAFPHEDYN): A potent analog of dynorphin 1-13

Intracerebroventricular administration of the dynorphin analog, [D-Ala2,(F5)Phe4]-dynorphin1-13-NH2 (DAFPHEDYN) in rats produced diuresis and profound analgesia. Both effects were antagonized by central administration of naltrexone or naloxone. Intravenous administration of 10, 25, and 50 mg/kg of DAFPHEDYN failed to induce diuresis. The increased potency of DAFPHEDYN was apparent from the failure of an equal dose of the parent compound (dynorphin 1-13) to produce diuresis and the failure of [D-Ala2]-dynorphin1-13-NH2 to produce analgesia. Radioligand binding studies indicated the DAFPHEDYN retains the same degree of [kappa] selectivity as the parent compound (dynorphin 1-13) though a drop in affinity occurred. DAFPHEDYN may be of significant interest because it retains the essential pharmacology of the parent compound and exhibits marked in vivo potency.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26600/1/0000141.pd