Bostonia. Volume 19

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

High-energy neutrino conversion and the lepton asymmetry in the universe

We study matter effects on oscillations of high-energy neutrinos in the Universe. Substantial effect can be produced by scattering of the neutrinos from cosmological sources (z\gta 1) on the relic neutrino background, provided that the latter has large CP-asymmetry: \eta\equiv (n_\nu-n_{\bar{\nu}})/n_\gamma\gta 1, where $n_\nu$, $n_{\bar{\nu}}$ and $n_\gamma$ are the concentrations of neutrinos, antineutrinos and photons. We consider in details the dynamics of conversion in the expanding neutrino background. Applications are given to the diffuse fluxes of neutrinos from GRBs, AGN, and the decay of super-heavy relics. We find that the vacuum oscillation probability can be modified by $\sim (10-20)$ and in extreme cases allowed by present bounds on $\eta$ the effect can reach $\sim 100$. Signatures of matter effects would consist (i) for both active-active and active-sterile conversion, in a deviation of the numbers of events produced in a detector by neutrinos of different flavours, $N_{\alpha}~(\alpha=e,\mu,\tau)$, and of their ratios from the values given by vacuum oscillations; such deviations can reach $\sim 5-15$, (ii) for active-sterile conversion, in a characteristic energy dependence of the ratios $N_{e}/N_{\mu},N_{e}/N_{\tau},N_{\mu}/N_{\tau}$. Searches for these matter effects will probe large CP and lepton asymmetries in the universe.Comment: 32 pages, RevTeX, 16 figures. Substantial changes in the treatment of conversion effects in the relic neutrino background and of active-active oscillations of high-energy neutrinos. Figures and references added; conclusions partially modifie

Neuroprotection in a Novel Mouse Model of Multiple Sclerosis

The authors acknowledge the support of the Barts and the London Charity, the Multiple Sclerosis Society of Great Britain and Northern Ireland, the National Multiple Sclerosis Society, USA, notably the National Centre for the Replacement, Refinement & Reduction of Animals in Research, and the Wellcome Trust (grant no. 092539 to ZA). The siRNA was provided by Quark Pharmaceuticals. The funders and Quark Pharmaceuticals had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Bostonia: The Boston University Alumni Magazine. Volume 18

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

MicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a

Hepatocellular carcinoma (HCC) is a heterogeneous tumor that develops via activation of multiple pathways and molecular alterations. It has been a challenge to identify molecular classes of HCC and design treatment strategies for each specific subtype. MicroRNAs (miRNAs) are involved in HCC pathogenesis and their expression profiles have been used to classify cancers. We analyzed miRNA expression in human HCC samples to identify molecular subclasses and oncogenic miRNAs

Bostonia: The Boston University Alumni Magazine. Volume 16

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs