548 research outputs found
Intraoperative Management of Robotic-Assisted Versus Open Radical Prostatectomy
Robotic-assisted laparoscopic radical prostatectomy was found to be a shorter procedure characterized by minimal blood loss, reduced fluid requirements, and shorter hospital stay compared with traditional open procedures
Brownian Simulations and Uni-Directional Flux in Diffusion
Brownian dynamics simulations require the connection of a small discrete
simulation volume to large baths that are maintained at fixed concentrations
and voltages. The continuum baths are connected to the simulation through
interfaces, located in the baths sufficiently far from the channel. Average
boundary concentrations have to be maintained at their values in the baths by
injecting and removing particles at the interfaces. The particles injected into
the simulation volume represent a unidirectional diffusion flux, while the
outgoing particles represent the unidirectional flux in the opposite direction.
The classical diffusion equation defines net diffusion flux, but not
unidirectional fluxes. The stochastic formulation of classical diffusion in
terms of the Wiener process leads to a Wiener path integral, which can split
the net flux into unidirectional fluxes. These unidirectional fluxes are
infinite, though the net flux is finite and agrees with classical theory. We
find that the infinite unidirectional flux is an artifact caused by replacing
the Langevin dynamics with its Smoluchowski approximation, which is classical
diffusion. The Smoluchowski approximation fails on time scales shorter than the
relaxation time of the Langevin equation. We find the unidirectional
flux (source strength) needed to maintain average boundary concentrations in a
manner consistent with the physics of Brownian particles. This unidirectional
flux is proportional to the concentration and inversely proportional to
to leading order. We develop a BD simulation that maintains
fixed average boundary concentrations in a manner consistent with the actual
physics of the interface and without creating spurious boundary layers
Tissue Self-Affinity and Polarized Light Scattering in the Born Approximation: A New Model for Precancer Detection
Linear systems with adiabatic fluctuations
We consider a dynamical system subjected to weak but adiabatically slow
fluctuations of external origin. Based on the ``adiabatic following''
approximation we carry out an expansion in \alpha/|\mu|, where \alpha is the
strength of fluctuations and 1/|\mu| refers to the time scale of evolution of
the unperturbed system to obtain a linear differential equation for the average
solution. The theory is applied to the problems of a damped harmonic oscillator
and diffusion in a turbulent fluid. The result is the realization of
`renormalized' diffusion constant or damping constant for the respective
problems. The applicability of the method has been critically analyzed.Comment: Plain Latex, no figure, 21 page
Random paths and current fluctuations in nonequilibrium statistical mechanics
An overview is given of recent advances in nonequilibrium statistical
mechanics about the statistics of random paths and current fluctuations.
Although statistics is carried out in space for equilibrium statistical
mechanics, statistics is considered in time or spacetime for nonequilibrium
systems. In this approach, relationships have been established between
nonequilibrium properties such as the transport coefficients, the thermodynamic
entropy production, or the affinities, and quantities characterizing the
microscopic Hamiltonian dynamics and the chaos or fluctuations it may generate.
This overview presents results for classical systems in the escape-rate
formalism, stochastic processes, and open quantum systems
Citrulline malate supplementation does not improve German Volume Training performance or reduce muscle soreness in moderately trained males and females
Background
Use of supplements to aid performance is common practice amongst recreationally active individuals, including those without a sufficient evidence base. This investigation sought to assess whether acute supplementation with 8 g of citrulline malate (CM) (1.11: 1 ratio) would improve anaerobic performance.
Methods
A randomised double blind placebo control trial was employed, using a counterbalanced design. We recruited recreationally active men and women to take part in an isokinetic chair protocol, based on German Volume Training (GVT) whereby participants attempted to perform 10 sets of 10 repetitions against a force representing 70% of their peak concentric force.
Results
The number of repetitions achieved over the course of the GVT was 94.0 ± 7.9 and 90.9 ± 13.9 for placebo and CM respectively. There was no significant difference between the placebo and CM treatment for number of repetitions (P = 0.33), isometric (P = 0.60), concentric (P = 0.38), or eccentric (P = 0.65) peak force following the GVT. Total muscle soreness was significantly higher in the CM compared to the placebo treatment following the GVT protocol over 72 h (P = 0.01); although this was not accompanied by a greater workload/number of repetitions in the CM group.
Conclusions
We conclude that an acute dose of CM does not significantly affect anaerobic performance using an isokinetic chair in recreational active participants. Practical implications include precaution in recommending CM supplementation. Coaches and athletes should be aware of the disparity between the chemical analyses of the products reviewed in the present investigation versus the manufacturers’ claims
Multichannel interference mitigation methods in radio astronomy
Radio-astronomical observations are increasingly corrupted by RF
interference, and online detection and filtering algorithms are becoming
essential. To facilitate the introduction of such techniques into radio
astronomy, we formulate the astronomical problem in an array signal processing
language, and give an introduction to some elementary algorithms from that
field. We consider two topics in detail: interference detection by rank
estimation of short-term covariance matrices, and spatial filtering by subspace
estimation and projection. We discuss experimental data collected at the
Westerbork radio telescope, and illustrate the effectiveness of the space-time
detection and blanking process on the recovery of a 3C48 absorption line in the
presence of GSM mobile telephony interference.Comment: 39 pages, 18 figures.Enhanced figures can be downloaded from
http://cas.et.tudelft.nl/~leshem/postscripts/leshem/figs34567.ps.gz To appear
in Astrophysical Journal Supplements serie
Non-commutative Geometry and Kinetic Theory of Open Systems
The basic mathematical assumptions for autonomous linear kinetic equations
for a classical system are formulated, leading to the conclusion that if they
are differential equations on its phase space , they are at most of the 2nd
order. For open systems interacting with a bath at canonical equilibrium they
have a particular form of an equation of a generalized Fokker-Planck type. We
show that it is possible to obtain them as Liouville equations of Hamiltonian
dynamics on with a particular non-commutative differential structure,
provided certain geometric in character, conditions are fulfilled. To this end,
symplectic geometry on is developped in this context, and an outline of the
required tensor analysis and differential geometry is given. Certain questions
for the possible mathematical interpretation of this structure are also
discussed.Comment: 22 pages, LaTe
The Toxicology Investigators Consortium 2020 Annual Report.
The Toxicology Investigators Consortium (ToxIC) Registry was established by the American College of Medical Toxicology in 2010. The registry collects data from participating sites with the agreement that all bedside and telehealth medical toxicology consultation will be entered. This eleventh annual report summarizes the Registry\u27s 2020 data and activity with its additional 6668 cases. Cases were identified for inclusion in this report by a query of the ToxIC database for any case entered from January 1 to December 31, 2020. Detailed data was collected from these cases and aggregated to provide information which included demographics, reason for medical toxicology evaluation, agent and agent class, clinical signs and symptoms, treatments and antidotes administered, mortality, and whether life support was withdrawn. Gender distribution included 50.6% cases in females, 48.4% in males, and 1.0% identifying as transgender. Non-opioid analgesics were the most commonly reported agent class, followed by opioid and antidepressant classes. Acetaminophen was once again the most common agent reported. There were 80 fatalities, comprising 1.2% of all registry cases. Major trends in demographics and exposure characteristics remained similar to past years\u27 reports. Sub-analyses were conducted to describe race and ethnicity demographics and exposures in the registry, telemedicine encounters, and cases related to the COVID-19 pandemic
Stochastic Physics, Complex Systems and Biology
In complex systems, the interplay between nonlinear and stochastic dynamics,
e.g., J. Monod's necessity and chance, gives rise to an evolutionary process in
Darwinian sense, in terms of discrete jumps among attractors, with punctuated
equilibrium, spontaneous random "mutations" and "adaptations". On an
evlutionary time scale it produces sustainable diversity among individuals in a
homogeneous population rather than convergence as usually predicted by a
deterministic dynamics. The emergent discrete states in such a system, i.e.,
attractors, have natural robustness against both internal and external
perturbations. Phenotypic states of a biological cell, a mesoscopic nonlinear
stochastic open biochemical system, could be understood through such a
perspective.Comment: 10 page
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