Study on magnetic thermal seeds coated with thermal-responsive molecularly imprinted polymers

We conceived a novel hybrid carrier of a thermal-responsive molecularly imprinted polymer (MIP) and a magnetic thermal seed (MTS) that showed a heat-generating ability under an alternate current (AC) magnetic field. Compared to our previous publications, we modify both the MIP and MTS to improve the feasibility for the hybrid carrier, briefly we have to achieve the accurate size control and narrower size distribution of MTS, and higher molecular recognition/release ability of MIP. Firstly, uniformly sized particles which are expected to show a large heat-generating ability under an AC magnetic field were successfully prepared by controlling the core creation. Then, an MIP targeted for selective adsorption of pemetrexed (PMX), a well-known anti-cancer drug, was prepared using N-carbobenzoxy-L-glutamic acid as a pseudo template. Finally, the preliminary hybridization of the MTS and the MIP-equivalent polymer coating was examined by introducing vinyl groups as methacrylic acid using a ligand exchanging method

Clinically Mild form of Joubert Syndrome-related Disorder in a 7-year-old Female:A case report

Joubert syndrome-related disorders (JSRD) is a very rare syndrome observed with agenesis of the vermis,episodic hyperpnea, abnormal eye movements, and cerebellar ataxia and mental retardation. There have been many reports on the image-based diagnosis using MRI/CT, but not many clinical reports on the intelligence of subjects with JSRD. We herein report a clinically mild form of JSRD in a 7-year-old female. The patient did not have any clinical abnormalities in the neonatal period.She initially visited the neurology outpatient department at 6 months of age because her neck was still unstable. A brain MRI was conducted to assess symptoms of abnormal eye movements and body trunk cerebella rataxia, and she was diagnosed with JSRD based on the observation of agenesis of the vermis and characteristic molar tooth signs. Regarding her motor development, she was able to hold her head up at 7months of age, and was able to sit up at 1 year and 2 months old. She underwent rehabilitation, and a wide base cerebellar gait was observed when she was 5 years old. In addition, at 5 years of age, she could intermittently speak two-word sentences, draw pictures with an understanding of color, and was able to engage in actions such as throwing a ball. At 6 years of age, her conversation became better. She entered elementary school at 7 years of age, was able to go up and down stairs, read words, do single-digit addition, and write many Chinese characters with a pencil. The intellectual dysfunction of subjects with JSRD is generally moderate to severe. Thus, this case was diagnosed to be a clinically mild form of JSRD, because the patient exhibited limited effects on her intelligence

Lennox-Gastaut Syndrome Associated with Unilateral Hemispheric Porencephaly

We report an 18 year-old male with a hemispheric large porencephaly who demonstrated symptomaticWest syndrome and then developed into Lennox-Gastaut syndrome. An electroencephalogram showed anasymmetrical high voltage slow spike and wave discharges only on the right side as a side of porencephalichemisphere. Interestingly, on the opposite side of the porencephalic hemisphere, an electroencephalogramshowed a low amplitude background activity in general. In this unique features both right side hemisphericporencephaly and asymmetric high voltage slow spike and waves due to Lennox-Gastaut syndrome, theporencephalic hemisphere due to cortical parenchymal loss may be more affected than the other hemisphereby epileptiform discharge in this patient

Image Analysis with the Brain Easy Analysis Tool (BEAT) Method in Cases of Encephalomalacia Following Shaken Baby Syndrome

Brain easy analysis tool( BEAT) is newly released software to calculate composite images both MRI andSPECT on computer graphics. At first, we herein report two cases with shaken baby syndrome associatedwith multicystic encephalomalasia diagnosed based on MRI. Next, we created fusion MRI-SPECT imagesusing BEAT. The result of composited images was not only well recognized in anatomical visually but alsoeasy to explain data to patients. This report is the second case report with this software called BEAT

Long survival case of trisomy 13 mosaicism in a 7-year-old male

Trisomy 13 is a complication of various congenital abnormalities of the heart, brain, etc. Regarding the vitalprognosis, many die within a year from birth. We herein report on the case of a 7-year 1-month-old boywith mosaicism trisomy 13 with the two considerations mentioned below as the cause for long-term survivalin this case. The first is that there were no serious associated abnormalities to the heart, brain, or otherorgans, and the second is that a tracheotomy was carried out on a repeated respiratory infection with respiratoryfailure. Long-term in-home care was possible for the child and he was observed playing with toys bytouching them. Trisomy 13 has a poor vital prognosis, so some argue that active treatment should be restrained.However, for cases with no severe associated abnormalities, long-term survival may be possiblewith active treatment

The IG-DMR and the MEG3-DMR at Human Chromosome 14q32.2: Hierarchical Interaction and Distinct Functional Properties as Imprinting Control Centers

Human chromosome 14q32.2 harbors the germline-derived primary DLK1-MEG3 intergenic differentially methylated region (IG-DMR) and the postfertilization-derived secondary MEG3-DMR, together with multiple imprinted genes. Although previous studies in cases with microdeletions and epimutations affecting both DMRs and paternal/maternal uniparental disomy 14-like phenotypes argue for a critical regulatory function of the two DMRs for the 14q32.2 imprinted region, the precise role of the individual DMR remains to be clarified. We studied an infant with upd(14)pat body and placental phenotypes and a heterozygous microdeletion involving the IG-DMR alone (patient 1) and a neonate with upd(14)pat body, but no placental phenotype and a heterozygous microdeletion involving the MEG3-DMR alone (patient 2). The results generated from the analysis of these two patients imply that the IG-DMR and the MEG3-DMR function as imprinting control centers in the placenta and the body, respectively, with a hierarchical interaction for the methylation pattern in the body governed by the IG-DMR. To our knowledge, this is the first study demonstrating an essential long-range imprinting regulatory function for the secondary DMR

ソウザン ジ ノ センエン セイ ハイ コウケツアツショウ ニ タイ スル NO キュウニュウ リョウホウ ノ ユウコウ セイ ・ アンゼン セイ ノ ケントウ

新生児遷延性肺高血圧症(persistent pulmonary hypertension of the newborn:PPHN)は,出生早期に肺高血圧症を発症し高度の低酸素血症を来す疾患である.正期産児のPPHNに対しては,NO吸入療法(inhaled nitric oxide:iNO)が有効とされているが,早産児における有効性は確立していない.今回,我々は在胎30週未満の早産児に対するiNOの有効性および安全性について検討した.対象は,出生後3日以内にiNOを施行した在胎30週未満の早産児39例である.肺高血圧の原因疾患は肺炎・敗血症が多かった.基礎疾患によって有効率が異なったが,iNO開始1時間の時点で全体の64%の症例はPPHNが改善した.PPHN改善後は速やかにiNOを減量・離脱できた症例が多かった.無効症例は週数・出生体重がより小さい児で多かった.有害事象としてはメトヘモグロビン血症を2例認めた.iNOは早産児のPPHNに対して,短期間の加療で出生早期の循環動態を改善させる有用な治療法であると考えられた.Persistent pulmonary hypertension of the newborn (PPHN) is a disease in which newborns develop pulmonary hypertension soon after birth, causing severe hypoxemia. Inhaled nitric oxide (iNO) therapy is effective in treating PPHN in term infants;however, the efficacy of iNO in preterm infants has not been established. We investigated the efficacy and safety of iNO as a treatment for preterm infants born at <30 weeks\u27 gestation. The subjects were 39 preterm infants born at <30 weeks\u27 gestation who underwent iNO therapy within 3 days of birth. The subjects\u27 pulmonary hypertension was most commonly caused by pneumonia and sepsis. PPHN improved in 64 % of the subjects 1 hour after starting iNO. In many subjects, iNO was successfully reduced and withdrawn promptly after PPHN improved. Subjects in whom iNO was ineffective were commonly those born early and with lower birth weight. Mild methemoglobinemia was complicated in 2 subjects. In preterm infants with PPHN, iNO is a useful therapythat causes few adverse events and improves hemodynamics soon after birth within a short amount of time

シンセイジ ニ タイスル ケイビテキ ジゾク ヨウアツ コキュウ ホウ ノ コウカ ト モンダイ テン

当院新生児集中治療室において経鼻的持続陽圧呼吸法を65例に施行し,その有効性と問題点について疾患別に検討した.出生後早期の呼吸障害である呼吸窮迫症候群では全例無効であったが,新生児一過性多呼吸では79%で有効であった.低出生体重児の慢性肺疾患では,抜管後の呼吸障害に85%で有効であった.無呼吸発作には,呼吸中枢の未熟性によるものには95%で有効であったが,薬剤の副作用による無呼吸に対しては無効であった.経鼻的持続陽圧呼吸法の合併症として,鼻部潰瘍および腹部膨満を3例に認めた.ただ,これらの合併症は,使用時間の短縮で減らすことが可能であると考えられた. Key Words: 新生児,経鼻的持続陽圧呼吸法,無呼吸発作We evaluated the effects and problems of nasal continuouspositive airway pressure (nasal CPAP) in 65 patientsadmitted to our neonatal intensive care unit. In neonateswith early onset respiratory problems after birth, nasalCPAP was effective for 79 % in transient tachypnea. However,no effect was observed in respiratory distress syndrome.Nasal CPAP was also effective for 85 % in post-extubationchronic lung disease and 95 % in apnea ofprematurity. Ulcers around the nose and abdominal distensionas adverse effects were observed in several neonates,however these risks may be reduced by shorting durationof nasal CPAP