The composition of meteoroids impacting LDEF

So far we have completed an initial scanning electron microscopy (SEM) survey of craters on the exterior of the Long Duration Exposure Facility (LDEF) in the 100 micron to 1mm size range and done some quantitative analysis. In typical craters, the residue appears to be a mixture of glass and FeNi and sulfide beads with an overall chondritic elemental composition. In less than 10 percent of the craters, there is a substantial amount of meteoroid debris that also contains unmelted mineral grains. The relatively high abundance of forsterite and enststite among these irregular grains suggests that a high melting point probably plays a role in surviving impact without melting

Polypectomy Techniques, Endoscopist Characteristics, and Serious Gastrointestinal Adverse Events

Background: A use of polypectomy techniques by endoscopist specialty (primary care, surgery, and gastroenterology) and experience (volume), and associations with serious gastrointestinal adverse events, were examined. Methods: A retrospective follow-up study with ambulatory surgery and hospital discharge datasets from Florida, 1999-2001, was used. Thirty-day hospitalizations due to colonic perforations and gastrointestinal bleeding were investigated for 323,585 patients. Results: Primary care endoscopists and surgeons used hot biopsy forceps/ablation, while gastroenterologists provided snare polypectomy or complex colonoscopy. Low-volume endoscopists were more likely to use simpler rather than complex procedures. For hot forceps/ablation and snare polypectomy, low- and medium-volume endoscopists reported higher odds of adverse events. For complex colonoscopy, higher odds of adverse events were reported for primary care endoscopists (1.74 [95%CI, 1.18 to 2.56]) relative to gastroenterologists Conclusions: Endoscopists regardless of specialty and experience can safely use cold biopsy forceps. For hot biopsy and snare polypectomy, low volume, but not specialty, contributed to increased odds of adverse events. For complex colonoscopy, primary care specialty, but not low volume, added to the odds of adverse events. Comparable outcomes were reported for surgeons and gastroenterologists. Cross-training and continuing medical education of primary care endoscopists in high-volume endoscopy settings are recommended for complex colonoscopy procedures

Stellar and Gas properties of High HI Mass-to-Light Ratio Galaxies in the Local Universe

We present a multi-wavelength study (BVRI band photometry and HI line interferometry) of nine late-type galaxies selected from the HIPASS Bright Galaxy Catalog on the basis of apparently high HI mass-to-light ratios (3 M_sun/L_sun < M_HI/L_B < 27 M_sun/L_sun). We found that most of the original estimates for M_HI/L_B based on available photographic magnitudes in the literature were too high, and conclude that genuine high HI mass-to-light ratio (>5 M_sun/L_sun) galaxies are rare in the Local Universe. Extreme high M_HI/L_B galaxies like ESO215-G?009 appear to have formed only the minimum number of stars necessary to maintain the stability of their HI disks, and could possibly be used to constrain galaxy formation models. They may to have been forming stars at a low, constant rate over their lifetimes. The best examples all have highly extended HI disks, are spatially isolated, and have normal baryonic content for their total masses but are deficent in stars. This suggests that high M_HI/L_B galaxies are not lacking the baryons to create stars, but are underluminous as they lack either the internal or external stimulation for more extensive star formation.Comment: 29 Pages, 59 Figures. Accepted for publication in AJ (to be published ~April 2006

Nighttime Traffic Volume Predicts Risk of Deer–Vehicle Collisions

Annually, in the United States, \u3e1 million deer (Odocoileus spp.)–vehicle collisions are reported, resulting in losses of $4.6 billion in vehicle damage and medical expenses. Wildlife and transportation managers require better information about traffic volumes relative to seasonal and diurnal deer movement patterns to appropriately evaluate the risks associated with deer–vehicle collisions (DVCs). We incorporated traffic volume data with DVC data and the movement rates and incidences of road crossings by white-tailed deer (O. virginianus) to evaluate if traffic volume or deer behaviors mediate the incidence of DVCs along a high-volume interstate highway in Morgan County in central Georgia, USA. From May 2012 to July 2014, we monitored the movements and survival of 25 deer (13 males, 12 females) instrumented with global positioning system (GPS) collars in an area 1.6 km north and south of a 7.7-km section of Interstate 20 in our study area. We used a linear mixed model to quantify the effects of mean traffic volume and total road crossings on DVCs for each hour of the day. Deer movements and DVCs were primarily crepuscular. Approximately 60% of GPS-collared deer crossed roads; 7 deer accounted for \u3e90% of all road crossings. Approximately 73% of daily traffic occurred between 0700 and 1859 hours. Nearly twice the number of daily DVCs occurred during the fall (9.8 DVCs/day) than during the next highest season (winter; 4.9 DVCs/day). Although DVCs occurred at greater frequencies during crepuscular periods, results of our linear mixed model suggested only nighttime traffic volume predicted DVCs. The relationship between nighttime DVCs and traffic volume is likely due to the inability of drivers to perceive deer in a roadway during this time. We recommend mitigation efforts focus on increasing driver vigilance and reducing vehicle speed during nighttime periods, especially during the fall season

Luminous Infrared Galaxies with the Submillimeter Array: I. Survey Overview and the Central Gas to Dust Ratio

We present new data obtained with the Submillimeter Array for a sample of fourteen nearby luminous and ultraluminous infrared galaxies. The galaxies were selected to have luminosity distances D < 200 Mpc and far-infrared luminosities log(L_FIR) > 11.4. The galaxies were observed with spatial resolutions of order 1 kpc in the CO J=3-2, CO J=2-1, 13CO J=2-1, and HCO+ J=4-3 lines as well as the continuum at 880 microns and 1.3 mm. We have combined our CO and continuum data to measure an average gas-to-dust mass ratio of 120 +/- 28 (rms deviation 109) in the central regions of these galaxies, very similar to the value of 150 determined for the Milky Way. This similarity is interesting given the more intense heating from the starburst and possibly accretion activity in the luminous infrared galaxies compared to the Milky Way. We find that the peak H_2 surface density correlates with the far-infrared luminosity, which suggests that galaxies with higher gas surface densities inside the central kiloparsec have a higher star formation rate. The lack of a significant correlation between total H_2 mass and far-infrared luminosity in our sample suggests that the increased star formation rate is due to the increased availability of molecular gas as fuel for star formation in the central regions. In contrast to previous analyses by other authors, we do not find a significant correlation between central gas surface density and the star formation efficiency, as trace by the ratio of far-infrared luminosity to nuclear gas mass. Our data show that it is the star formation rate, not the star formation efficiency, that increases with increasing central gas surface density in these galaxies.Comment: 66 pages, 39 figures, aastex preprint format; to be published in ApJ Supplements. Version of paper with full resolution figures available at http://www.physics.mcmaster.ca/~wilson/www_xfer/ULIRGS_publi

Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis.

We previously reported that renal clear cell carcinoma cells (RCC) express both tumor necrosis factor receptor (TNFR)-1 and -2, but that, in organ culture, a TNF mutein that only engages TNFR1, but not TNFR2, causes extensive cell death. Some RCC died by apoptosis based on detection of cleaved caspase 3 in a minority TUNEL-positive cells but the mechanism of death in the remaining cells was unexplained. Here, we underpin the mechanism of TNFR1-induced cell death in the majority of TUNEL-positive RCC cells, and show that they die by necroptosis. Malignant cells in high-grade tumors displayed threefold to four fold higher expression of both receptor-interacting protein kinase (RIPK)1 and RIPK3 compared with non-tumor kidney tubular epithelium and low-grade tumors, but expression of both enzymes was induced in lower grade tumors in organ culture in response to TNFR1 stimulation. Furthermore, TNFR1 activation induced significant MLKL(Ser358) and Drp1(Ser616) phosphorylation, physical interactions in RCC between RIPK1-RIPK3 and RIPK3-phospho-MLKL(Ser358), and coincidence of phospho-MLKL(ser358) and phospho-Drp1(Ser616) at mitochondria in TUNEL-positive RCC. A caspase inhibitor only partially reduced the extent of cell death following TNFR1 engagement in RCC cells, whereas three inhibitors, each targeting a different step in the necroptotic pathway, were much more protective. Combined inhibition of caspases and necroptosis provided additive protection, implying that different subsets of cells respond differently to TNF-α, the majority dying by necroptosis. We conclude that most high-grade RCC cells express increased amounts of RIPK1 and RIPK3 and are poised to undergo necroptosis in response to TNFR1 signaling.National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre , Kidney Research UK and NIH grant R01-HL36003.This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by Nature Publishing Group

The feasibility, safety, and efficacy of lower limb garment-integrated blood flow restriction training in healthy adults.

Objectives Explore the feasibility of lower-limb garment-integrated BFR-training. Design Observational study. Setting Human performance laboratory. Participants Healthy males with no experience of BFR-training. Main outcome measures Feasibility was determined by a priori thresholds for recruitment, adherence, and data collection. Safety was determined by measuring BFR torniquet pressure and the incidence of side effects. Efficacy was determined by measuring body anthropometry and knee isokinetic dynamometry. Feasibility and safety outcomes were reported descriptively or as a proportion with 95% confidence intervals (95% CI), with mean change, 95% CIs, and effect sizes for efficacy outcomes. Results Twelve participants (mean age 24.8 years [6.5]) were successfully recruited; 11 completed the study. 134/136 sessions were completed (adherence = 98.5%) and 100% of data were collected. There was one event of excessive pain during exercise (0.7%, 95% CI 0.0%, 4.0%), two events of excessive pain post-exercise (1.5%, 95% CI 0.4%, 5.5%), and one event of persistent paraesthesia post-exercise (0.7%, 95% CI 0.0%, 4.0%). Mean maximal BFR torniquet pressure was <200 mmHg. We observed an increase in knee extension peak torque (mean change 12.4 Nm), but no notable changes in body anthropometry. Conclusions Lower-limb garment-integrated BFR-training is feasible, has no signal of important harm, and could be used independently

Kennesaw State University Choral Ensembles Spring Concert

Please join us for an evening of choral masterworks presented by KSU choral ensembles. The evening will feature performances by the KSU Chamber Choir, led by Interim Director of the School of Music and Director of Choral Activities Dr. Leslie J. Blackwell, as well as the University Chorale and Men\u27s Ensemble, both led by Dr. Reid Masters. The Chamber Singers will be giving a preview of their performance at the 2020 ACDA Southern Division Conference.https://digitalcommons.kennesaw.edu/musicprograms/2304/thumbnail.jp

A pilot study of basal ganglia and thalamus structure by high dimensional mapping in children with Tourette syndrome

Background: Prior brain imaging and autopsy studies have suggested that structural abnormalities of the basal ganglia (BG) nuclei may be present in Tourette Syndrome (TS). These studies have focused mainly on the volume differences of the BG structures and not their anatomical shapes.  Shape differences of various brain structures have been demonstrated in other neuropsychiatric disorders using large-deformation, high dimensional brain mapping (HDBM-LD).  A previous study of a small sample of adult TS patients demonstrated the validity of the method, but did not find significant differences compared to controls. Since TS usually begins in childhood and adult studies may show structure differences due to adaptations, we hypothesized that differences in BG and thalamus structure geometry and volume due to etiological changes in TS might be better characterized in children. Objective: Pilot the HDBM-LD method in children and estimate effect sizes. Methods: In this pilot study, T1-weighted MRIs were collected in 13 children with TS and 16 healthy, tic-free, control children. The groups were well matched for age.  The primary outcome measures were the first 10 eigenvectors which are derived using HDBM-LD methods and represent the majority of the geometric shape of each structure, and the volumes of each structure adjusted for whole brain volume. We also compared hemispheric right/left asymmetry and estimated effect sizes for both volume and shape differences between groups. Results: We found no statistically significant differences between the TS subjects and controls in volume, shape, or right/left asymmetry.  Effect sizes were greater for shape analysis than for volume. Conclusion: This study represents one of the first efforts to study the shape as opposed to the volume of the BG in TS, but power was limited by sample size. Shape analysis by the HDBM-LD method may prove more sensitive to group differences

Match physical performance of elite female soccer players during international competition.

The purpose of the present study was to provide a detailed analysis of the physical demands of competitive international female soccer match-play. A total of 148 individual match observations were undertaken on 107 outfield players competing in competitive international matches during the 2011-2012 and 2012-2013 seasons, using a computerized tracking system (Prozone Sports Ltd., Leeds, England). Total distance (TD) and total high-speed running distances (THSR) were influenced by playing position, with central midfielders (CM) completing the highest (10985±706 m and 2882±500 m) and central defenders (CD) the lowest (9489±562 m and 1901±268 m) distances, respectively. Greater total very high-speed running (TVHSR) distances were completed when a team was without (399±143 m) compared to with (313±210 m) possession of the ball. The majority of sprints were over short distances with 76 % and 95 % being less than 5 m and 10 m, respectively. Between half reductions in physical performance were present for all variables, independent of playing position. The current study provides novel findings regarding the physical demands of different playing positions in competitive international female match-play and provides important insights for physical coaches preparing elite female players for competition