A bayesian approach to the vertical structure of the disk of the Milky Way

This work investigates the vertical profile of the stars in the disk of the Milky Way. The models investigated are of the form sech2/n(nz/(2H)) where, setting α = 2/n, the three functions of the sequence α= 0, 1, 2 correspond to exponential, sech, and sech2 functions respectively. We consider symmetric models and asymmetric models, above and below the plane. The study uses the large sample of K and M stars of Ferguson et al. (2017) and applies the methods of Bayesian model comparison to discriminate between the 6 models. Two inconsistencies in Ferguson et al. (2017), concerning the vertical height cut and the model continuity across the plane, are noted and addressed. We find that (1) in the Milky Way the symmetric disc models are decisively ruled out, with northern thin disc scale heights about 25% larger than southern, (2) there is moderate evidence for the exponential and sech models over the sech2 model, though a sample extending further into the Galactic mid-plane is needed to strengthen this result, (3) the photometric distances used by Ferguson et al. underestimate the GAIA distances by a factor of roughly 1.16, and (4) the increase of scale height with Galactic latitude observed by Ferguson et al. is due to incorrect cuts to the data

The undiscovered syndrome: Macdonald Critchley's case of semantic dementia

Semantic dementia is a unique clinicopathological syndrome in the frontotemporal lobar degeneration spectrum. It is characterized by progressive and relatively selective impairment of semantic memory, associated with asymmetric antero-inferior temporal lobe atrophy. Although the syndrome became widely recognized only in the 1980s, descriptions of cases with typical features of semantic dementia have been on record for over a century. Here, we draw attention to a well documented historical case of a patient with features that would have fulfilled current consensus criteria for semantic dementia, as reconstructed from the notes made by her neurologist, Macdonald Critchley, in 1938. This case raises a number of issues concerning the nosology of the semantic dementia syndrome and the potential value of archived case material

A spectroscopic survey for strong galaxy-galaxy lenses

We present a spectroscopic survey for strong galaxy-galaxy lenses. Exploiting optimal sight-lines to massive, bulge-dominated galaxies at redshifts $z \sim 0.4$ with wide-field, multifibre spectroscopy, we anticipate the detection of 10-20 lensed Lyman-$\alpha$ emitting galaxies at redshifts z \simgreat 3 from a sample of 2000 deflectors. Initial spectroscopic observations are described and the prospects for constraining the emission-line luminosity function of the Lyman-$\alpha$ emitting population are outlined

Intact reading in patients with profound early visual dysfunction

Despite substantial neuroscientific evidence for a region of visual cortex dedicated to the processing of written words, many studies continue to reject explanations of letter-by-letter (LBL) reading in terms of impaired word form representations or parallel letter processing in favour of more general deficits of visual function. In the current paper, we demonstrate that whilst LBL reading is often associated with general visual deficits, these deficits are not necessarily sufficient to cause reading impairment and have led to accounts of LBL reading which are based largely on evidence of association rather than causation. We describe two patients with posterior cortical atrophy (PCA) who exhibit remarkably preserved whole word and letter reading despite profound visual dysfunction. Relative to controls, both patients demonstrated impaired performance on tests of early visual, visuoperceptual and visuospatial processing; visual acuity was the only skill preserved in both individuals. By contrast, both patients were able to read aloud words with perfect to near-perfect accuracy. Reading performance was also rapid with no overall significant difference in response latencies relative to age- and education-matched controls. Furthermore, the patients violated a key prediction of general visual accounts of LBL reading – that pre-lexical impairments should result in prominent word length effects; in the two reported patients, evidence for abnormal word length effects was equivocal or absent, and certainly an order of magnitude different to that reported for LBL readers. We argue that general visual accounts cannot explain the pattern of reading data reported, and attribute the preserved reading performance to preserved direct access to intact word form representations and/or parallel letter processing mechanisms. The current data emphasise the need for much clearer evidence of causality when attempting to draw connections between specific aspects of visual processing and different types of acquired peripheral dyslexia

The Astro-WISE approach to quality control for astronomical data

We present a novel approach to quality control during the processing of astronomical data. Quality control in the Astro-WISE Information System is integral to all aspects of data handing and provides transparent access to quality estimators for all stages of data reduction from the raw image to the final catalog. The implementation of quality control mechanisms relies on the core features in this Astro-WISE Environment (AWE): an object-oriented framework, full data lineage, and both forward and backward chaining. Quality control information can be accessed via the command-line awe-prompt and the web-based Quality-WISE service. The quality control system is described and qualified using archive data from the 8-CCD Wide Field Imager (WFI) instrument (http://www.eso.org/lasilla/instruments/wfi/) on the 2.2-m MPG/ESO telescope at La Silla and (pre-)survey data from the 32-CCD OmegaCAM instrument (http://www.astro-wise.org/~omegacam/) on the VST telescope at Paranal.Comment: Accepted for publication in topical issue of Experimental Astronomy on Astro-WISE information syste

Accent processing in dementia

Accented speech conveys important nonverbal information about the speaker as well as presenting the brain with the problem of decoding a non-canonical auditory signal. The processing of non-native accents has seldom been studied in neurodegenerative disease and its brain basis remains poorly understood. Here we investigated the processing of non-native international and regional accents of English in cohorts of patients with Alzheimer's disease (AD; n=20) and progressive nonfluent aphasia (PNFA; n=6) in relation to healthy older control subjects (n=35). A novel battery was designed to assess accent comprehension and recognition and all subjects had a general neuropsychological assessment. Neuroanatomical associations of accent processing performance were assessed using voxel-based morphometry on MR brain images within the larger AD group. Compared with healthy controls, both the AD and PNFA groups showed deficits of non-native accent recognition and the PNFA group showed reduced comprehension of words spoken in international accents compared with a Southern English accent. At individual subject level deficits were observed more consistently in the PNFA group, and the disease groups showed different patterns of accent comprehension impairment (generally more marked for sentences in AD and for single words in PNFA). Within the AD group, grey matter associations of accent comprehension and recognition were identified in the anterior superior temporal lobe. The findings suggest that accent processing deficits may constitute signatures of neurodegenerative disease with potentially broader implications for understanding how these diseases affect vocal communication under challenging listening conditions

Visual dysfunction in Parkinson's disease

Patients with Parkinson's disease have a number of specific visual disturbances. These include changes in colour vision and contrast sensitivity and difficulties with complex visual tasks such as mental rotation and emotion recognition. We review changes in visual function at each stage of visual processing from retinal deficits, including contrast sensitivity and colour vision deficits to higher cortical processing impairments such as object and motion processing and neglect. We consider changes in visual function in patients with common Parkinson's disease-associated genetic mutations including GBA and LRRK2 We discuss the association between visual deficits and clinical features of Parkinson's disease such as rapid eye movement sleep behavioural disorder and the postural instability and gait disorder phenotype. We review the link between abnormal visual function and visual hallucinations, considering current models for mechanisms of visual hallucinations. Finally, we discuss the role of visuo-perceptual testing as a biomarker of disease and predictor of dementia in Parkinson's disease

Better conversations: a language and communication intervention for aphasia in posterior cortical atrophy

Posterior cortical atrophy (PCA) describes a neurodegenerative syndrome characterized by progressive difficulties in cortical visual and other posterior cortical functions consistent with parieto-occipital and occipito-temporal involvement. It is increasingly recognized that many patients develop difficulties with other aspects of daily living, in particular, with language and communication. We present a case emphasizing how language difficulties may emerge in PCA. Difficulties are interpreted as arising from interacting effects of linguistic deficits and impaired detection of nonverbal (particularly, visual) turns that normally facilitate, schedule, and disambiguate the exchange of verbal messages between speakers. We propose that relatively simple speech and language therapy interventions may hold promise in addressing language and communication difficulties as secondary features of PCA by targeting the behaviors of both the person with PCA and their communication partners

Auditory object cognition in dementia

The cognition of nonverbal sounds in dementia has been relatively little explored. Here we undertook a systematic study of nonverbal sound processing in patient groups with canonical dementia syndromes comprising clinically diagnosed typical amnestic Alzheimer's disease (AD; n = 21), progressive nonfluent aphasia (PNFA; n = 5), logopenic progressive aphasia (LPA; n = 7) and aphasia in association with a progranulin gene mutation (GAA; n = 1), and in healthy age-matched controls (n = 20). Based on a cognitive framework treating complex sounds as 'auditory objects', we designed a novel neuropsychological battery to probe auditory object cognition at early perceptual (sub-object), object representational (apperceptive) and semantic levels. All patients had assessments of peripheral hearing and general neuropsychological functions in addition to the experimental auditory battery. While a number of aspects of auditory object analysis were impaired across patient groups and were influenced by general executive (working memory) capacity, certain auditory deficits had some specificity for particular dementia syndromes. Patients with AD had a disproportionate deficit of auditory apperception but preserved timbre processing. Patients with PNFA had salient deficits of timbre and auditory semantic processing, but intact auditory size and apperceptive processing. Patients with LPA had a generalised auditory deficit that was influenced by working memory function. In contrast, the patient with GAA showed substantial preservation of auditory function, but a mild deficit of pitch direction processing and a more severe deficit of auditory apperception. The findings provide evidence for separable stages of auditory object analysis and separable profiles of impaired auditory object cognition in different dementia syndromes. (C) 2011 Elsevier Ltd. All rights reserved

Galaxy mass profiles from strong lensing II: The elliptical power-law model

We present a systematic analysis of the constraints σγ on the mass profile slope γ obtainable when fitting a singular power-law ellipsoid model to a typical strong lensing observation of an extended source. These results extend our previous analysis of circular systems, Paper I. We draw our results from 676 mock observations covering a range of image configurations, each created with a fixed signal to noise ratio S = 100 in the images. We analyse the results using a combination of theory and a simplified model which identifies the contribution to the constraints of the individual fluxes and positions in each of the lensed images. The main results are: 1. For any lens ellipticity, the constraints σγ for two image systems are well described by the results of Paper I, transformed to elliptical coordinates; 2. We derive an analytical expression for σγ for systems with the source aligned with the axis of the lens; 3. For both two-image systems and aligned systems, σγ is limited by the flux uncertainties; 4. The constraints for off-axis four-image systems are a factor of two to eight better, depending on source size, than for two-image systems, and improve with increasing lens ellipticity. We show that the constraints on γ in these systems derive from the complementary positional information of the images alone, without using flux. The complementarity improves as the offset of the source from the axis increases, such that the best constraints σγ < 0.01, for S = 100, occur when the source approaches the caustic