Non-genomic actions of aldosterone: From receptors and signals to membrane targets.

In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the expression of membrane targets such as the subunits of the epithelial Na(+) channel, in combination with important signalling intermediates such as serum and glucocorticoid-regulated kinase-1. In addition, the rapid \u27non-genomic\u27 activation of protein kinases and secondary messenger signalling cascades has also been detected in aldosterone-sensitive tissues of the nephron, distal colon and cardiovascular system. These rapid actions are variously described as being coupled to MR or to an as yet unidentified, membrane-associated aldosterone receptor. The rapidly activated signalling cascades add a level of fine-tuning to the activity of aldosterone-responsive membrane transporters and also modulate the aldosterone-induced changes in gene expression through receptor and transcription factor phosphorylation

Open Budgets. Transform Lives. The Open Budget Survey 2008

Provides a comparative measure of government budget transparency in eighty-five countries. Discusses contributing factors and makes recommendations for improving transparency, increasing public participation, and strengthening accountability oversight

Aldosterone as a renal growth factor

Aldosterone regulates blood pressure through its effects on the cardiovascular system and kidney. Aldosterone can also contribute to the development of hypertension that leads to chronic pathologies such as nephropathy and renal fibrosis. Aldosterone directly modulates renal cell proliferation and differentiation as part of normal kidney development. The stimulation of rapidly activated protein kinase cascades is one facet of how aldosterone regulates renal cell growth. These cascades may also contribute to myofibroblastic transformation and cell proliferation observed in pathological conditions of the kidney. Polycystic kidney disease is a genetic disorder that is accelerated by hypertension. EGFR-dependent proliferation of the renal epithelium is a factor in cyst development and trans-activation of EGFR is a key feature in initiating aldosterone-induced signalling cascades. Delineating the components of aldosterone-induced signalling cascades may identify novel therapeutic targets for proliferative diseases of the kidney

Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland

While acute respiratory tract infections can trigger cardiovascular events, the differential effect of specific organisms is unknown. This is important to guide vaccine policy.Using national infection surveillance data linked to the Scottish Morbidity Record, we identified adults with a first myocardial infarction or stroke from January 1, 2004 to December 31, 2014 and a record of laboratory-confirmed respiratory infection during this period. Using self-controlled case series analysis, we generated age- and season-adjusted incidence ratios (IRs) for myocardial infarction (n=1227) or stroke (n=762) after infections compared with baseline time.We found substantially increased myocardial infarction rates in the week after Streptococcus pneumoniae and influenza virus infection: adjusted IRs for days 1-3 were 5.98 (95% CI 2.47-14.4) and 9.80 (95% CI 2.37-40.5), respectively. Rates of stroke after infection were similarly high and remained elevated to 28 days: day 1-3 adjusted IRs 12.3 (95% CI 5.48-27.7) and 7.82 (95% CI 1.07-56.9) for S. pneumoniae and influenza virus, respectively. Although other respiratory viruses were associated with raised point estimates for both outcomes, only the day 4-7 estimate for stroke reached statistical significance.We showed a marked cardiovascular triggering effect of S. pneumoniae and influenza virus, which highlights the need for adequate pneumococcal and influenza vaccine uptake. Further research is needed into vascular effects of noninfluenza respiratory viruses

Investigation of the Relationship Between Dress Conformity and Academic Achievement of Tenth Grade Students in a Metropolitan High School

Clothing, Textiles, and Merchandisin

Features of Explainability: How users understand counterfactual and causal explanations for categorical and continuous features in XAI

Counterfactual explanations are increasingly used to address interpretability, recourse, and bias in AI decisions. However, we do not know how well counterfactual explanations help users to understand a systems decisions, since no large scale user studies have compared their efficacy to other sorts of explanations such as causal explanations (which have a longer track record of use in rule based and decision tree models). It is also unknown whether counterfactual explanations are equally effective for categorical as for continuous features, although current methods assume they do. Hence, in a controlled user study with 127 volunteer participants, we tested the effects of counterfactual and causal explanations on the objective accuracy of users predictions of the decisions made by a simple AI system, and participants subjective judgments of satisfaction and trust in the explanations. We discovered a dissociation between objective and subjective measures: counterfactual explanations elicit higher accuracy of predictions than no-explanation control descriptions but no higher accuracy than causal explanations, yet counterfactual explanations elicit greater satisfaction and trust than causal explanations. We also found that users understand explanations referring to categorical features more readily than those referring to continuous features. We discuss the implications of these findings for current and future counterfactual methods in XAI.Comment: 26 pages, 7 figures, appendi