Links between depressive symptoms and the observer perspective for autobiographical memories and imagined events:a high familial risk study

Depression is associated with increased observer visual perspective for positive autobiographical memories. However, it is unclear if this relationship (1) is present in individuals at high familial risk of depression; (2) is a general bias extending to future imagined events; and (3) is independent of general cognition and other cognitive biases. We examined the association of observer perspective, valence (positive, negative, neutral) and temporality (memories, future imagined events) with depressive symptoms in 29 young adults at high familial risk for depression. Increased observer perspective for memories was associated with dimensional depressive symptoms controlling for IQ and autobiographical specificity. There was weak evidence that increased observer perspective for future events was associated with a diagnostic measure of depressive symptoms, but limited evidence that perspective by valence interactions were associated with depressive symptoms. Results indicate depressive symptoms are associated with an observer perspective bias in autobiographical thinking regardless of temporality or valence

Examining the relationship between stressful life events and overgeneral autobiographical memory in adolescents at high familial risk of depression

Difficulty remembering specific events from the personal past, known as overgeneral autobiographical memory (AM), may be a marker of vulnerability to adolescent depression but little is known about how overgeneral AM arises in this age group. Stressful life events (SLEs) are strongly implicated in the onset of depression and are considered important in theoretical work on AM. We investigated whether exposure to lifetime and recent SLEs contributed to the development of overgeneral AM in a sample of adolescents at high familial risk of depression (n = 257) and examined the effects of gender and memory valence. Whether AM mediated the relationship between SLEs and MDD was also assessed. Exposure to a higher number of lifetime SLEs was associated with an increase in specific AMs. Associations of recent SLEs with AM differed by gender. For girls, more recent SLEs were associated with more overgeneral AMs. For boys, more recent SLEs were associated with fewer overgeneral AMs and more specific AMs. AM did not mediate the relationship between SLEs and subsequent DSM-IV depressive symptom count. Results suggest a complex relationship between AM and SLEs and that overgeneral AM and SLEs may have independent effects on future depression

Autobiographical memory and early-onset depression: Insights from the environment, genetics and brain structure

Difficulty remembering specific events from the personal past, known as overgeneral autobiographical memory (AM), has been associated with adult depression. However, evidence for overgeneral memory as a risk factor for early-onset depression is less consistent, and the aetiology of overgeneral memory is not well understood. The aim of this thesis was to examine whether overgeneral memory could be a risk factor or risk mechanism for early-onset depression. I first examined the cross-sectional and longitudinal relationships between overgeneral memory and depression. Overgeneral AM to negative cues was associated with cross-sectional depressive symptoms and depressive symptoms three years later, thereby indicating temporal precedence. I also assessed whether overgeneral memory was a risk mechanism through which known risk factors for depression (stressful life events (SLEs) and genetic risk) exert their effects. Although overgeneral memory was associated with SLEs, it did not mediate the relationship with depression. Instead, results suggested overgeneral memory and SLEs exert independent effects on subsequent depression. In contrast, overgeneral memory was not associated with common genetic risk for depression. Finally I investigated whether white matter connections in the brain could help explain the link between overgeneral memory and depression. White matter tracts previously associated with depression were linked to specific AMs that were positive in content but not to other measures of AM. In combination, these finding suggest that overgeneral memory is a risk factor for early-onset depression although observed effect sizes were small. Thus, targeting overgeneral memory could be useful for treatment and prevention of early-onset depression. Overgeneral memory was not a mechanism for known risk factors of depression (SLEs and genetic risk). The association with white matter tracts involved in depression provides preliminary evidence that overgeneral memory could be a risk mechanism for depression. Nevertheless, preliminary evidence from this small cross-sectional study requires replication in larger, longitudinal studies

Do children with recurrent abdominal pain grow up to become adolescents who control their weight by fasting?:Results from a UK population-based cohort

Objective Gastrointestinal (GI) problems are common in eating disorders, but it is unclear whether these problems predate the onset of disordered eating. Recurrent abdominal pain (RAP) is the most prevalent GI problem of childhood, and this study aimed to explore longitudinal associations between persistent RAP (at ages 7 and 9) and fasting for weight control at 16. Method The Avon Longitudinal Study of Parents and Children (ALSPAC) is a UK population cohort of children. Childhood RAP was reported by mothers and defined as RAP 5+ (5 pain episodes in the past year) in our primary analysis, and RAP 3+ (3 pain episodes) in our sensitivity analysis. Fasting for weight control was reported by adolescents at 16. We used logistic regression models to examine associations, with adjustments for potential confounders. Results After adjustments, we found no association between childhood RAP 5+ and adolescent fasting for weight control at 16 (OR 1.30 (95% Confidence Intervals [CI] 0.87, 1.94) p = .197). However, we did find an association between RAP 3+ and later fasting, in the fully adjusted model (OR 1.50 [95% CI 1.16, 1.94] p = .002), and after excluding those with pre‐existing anxiety (OR 1.52 [95% CI 1.17, 1.97] p = .002). Discussion Our findings suggest a possible independent contribution of RAP to later risk of fasting for weight control, and RAP should be enquired about in the assessment of eating disorders. However, frequency of childhood abdominal pain (as captured by ALSPAC) may be less important to long‐term outcomes than functional impairment

Cross-cohort change in adolescent outcomes for children with mental health problems

Background Child mental health problems are common. Previous studies have examined secular changes in their prevalence but have not assessed whether later outcomes have changed. We therefore aimed to test whether outcomes of child mental health problems have changed over a 40-year period. Methods Three cohorts were utilised: the National Child Development Study (NCDS: N = 14544, aged 7 in 1965), the Avon Longitudinal Study of Parents and Children (ALSPAC: N = 8188, aged 7 in 1998), and the Millennium Cohort Study (MCS: N = 13192, aged 7 in 2008). Mental health problems at age 7 were identified using the parent-reported Rutter A scale (NCDS) and Strengths and Difficulties Questionnaire (ALSPAC and MCS). Associated outcomes were compared across cohorts: age 11 social functioning, age 16 exam attainment and age 16 mental health. Results Child mental health problems were common in each cohort (boys: 7.0%-9.7%; girls: 5.4%-8.4%). Child mental health problems became more strongly associated with social functioning problems (boys: NCDS OR = 1.95 (1.50, 2.53), MCS OR = 3.77 (2.89, 4.92); interaction p < .001; girls: NCDS OR = 1.69 (1.22, 2.33), MCS OR = 3.99 (3.04, 5.25), interaction p < .001), lower academic attainment for boys (NCDS OR = 0.49 (0.31, 0.78), ALSPAC OR = 0.30 (0.22, 0.41), interaction p = .009), and age 16 mental health problems (boys: NCDS d’ = 0.55 (0.38, 0.72), ALSAPC d’ = 0.95 (0.73, 1.16); interaction p = .004; girls: NCDS d’ = 0.50 (0.34, 0.65), ALSPAC d’ = 0.99 (0.78, 1.20); interaction p < .001). Conclusions Child mental health problems have become more strongly associated with negative social, educational and mental health outcomes in recent generations

Distinct contributions of the fornix and inferior longitudinal fasciculus to episodic and semantic autobiographical memory

Autobiographical memory (AM) is multifaceted, incorporating the vivid retrieval of contextual detail (episodic AM), together with semantic knowledge that infuses meaning and coherence into past events (semantic AM). While neuropsychological evidence highlights a role for the hippocampus and anterior temporal lobe (ATL) in episodic and semantic AM, respectively, it is unclear whether these constitute dissociable large-scale AM networks. We used high angular resolution diffusion-weighted imaging and constrained spherical deconvolution-based tractography to assess white matter microstructure in 27 healthy young adult participants who were asked to recall past experiences using word cues. Inter-individual variation in the microstructure of the fornix (the main hippocampal input/output pathway) related to the amount of episodic, but not semantic, detail in AMs e independent of memory age. Conversely, microstructure of the inferior longitudinal fasciculus, linking occipitotemporal regions with ATL, correlated with semantic, but not episodic, AMs. Further, these significant correlations remained when controlling for hippocampal and ATL grey matter volume, respectively. This striking correlational double dissociation supports the view that distinct, large-scale distributed brain circuits underpin context and concepts in AM

Responding to American Indian Communities: Southwest American Indian Collaborative Network (SAICN) Cancer Educational Activities

Developing educational materials and providing trainings in American Indian communities is a highly rewarding activity. However, to do so successfully a number of complex issues must be faced and cultural-tailored strategies to promote awareness must be developed based on the unique traditions of each tribe. In this paper we describe the educational activities conducted over a four year period by the Southwest American Indian Collaborative Network, a project funded by the National Cancer Institute’s Center to Reduce Cancer Health Disparities. Activities fell into two broad areas: dissemination of cancer information through trainings and workshops and development of culturally-tailored educational materials