6 research outputs found
CDKN1A and FANCD2 are potential oncotargets in Burkitt lymphoma and multiple myeloma
- Author
- A Viale
- AL Kovalchuk
- DN Yarde
- E De la Cueva
- F Zhan
- GD Bren
- GP Dotto
- H Xiao
- IB Roninson
- J Martin-Caballero
- JD Shaughnessy Jr
- JI Yook
- JR Basile
- JW Harper
- JW Lim
- JW Lim
- K Bhatia
- K Duncan
- KH Shair
- MA Rego
- MJ Rey
- NA Warfel
- R Erber
- S Janz
- S Rutsch
- S Suematsu
- S Suematsu
- SJ Russell
- SS Dave
- SS Han
- SS Han
- SS Han
- SS Park
- SV Rajkumar
- T Abbas
- TS Kumaravel
- VS Romanov
- WC Huang
- WS El-Deiry
- Y Zhou
- YA Wang
- Z Yu
- ZL Yuan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer
- Author
- A MartĂnez
- A Ziegler
- AA Saetta
- AJ Levine
- AM Valentini
- C Campregher
- C Ciccarelli
- CH Chang
- Denise HĂ©len Imaculada Pereira de Oliveira
- DJ Sarmento
- Dmitry José de Santana Sarmento
- E Giarnieri
- EE Souza Lucena de
- F Afaq
- F Köster
- FC Xavier
- H BĂ€ckvall
- H Ikehata
- HAR Pontes
- HR Park
- I Spagnoletti
- IJ Rojas
- J Liu
- K Piñera-Marques
- L Barnes
- LR Souza
- LĂ©lia Maria Guedes Queiroz
- M Bryne
- M PĂ©rez-SayĂĄns
- Maria Luiza Diniz de Sousa Lopes
- MC Horta
- MR Hussein
- MĂĄrcia Cristina da Costa Miguel
- NA Warfel
- P Peltomaki
- PC Caldeira
- PM Rodust
- R MercuĆŁ
- S Staibano
- S Tsurusako
- SJ Scherer
- T Megha
- TE Helal
- VA Tron
- W Nasser
- WS El-Deiry
- Y Kang
- Y Kudo
- Ăricka Janine Dantas da Silveira
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability
- Author
- A Seeber
- A Seeber
- A Tosi
- AD Truax
- C Norbury
- CB Gerhold
- CL Wei
- CR Clapier
- F Wang
- Fei Wang
- G Bennett
- GR Stark
- H Ogata
- H van Attikum
- I Dutto
- I Vassileva
- J CmielovĂĄ
- J Jin
- J Jin
- JH An
- Jiaming Su
- Jian Ding
- Jiayao Zhao
- Jingji Jin
- JJ Tyson
- JN Min
- K Lee
- K Shimada
- K Shimada
- L Chen
- L Wang
- Liguo Dong
- Lingling Cao
- Lingyao Wang
- M Ashburner
- N GĂ©vry
- NA Warfel
- Q Li
- RC Conaway
- S Kashiwaba
- S Watanabe
- SK Hur
- Thomas G. Hofmann
- Tong Zhao
- V Dion
- VG Gorgoulis
- VQ Nguyen
- W Huang da
- W Huang da
- W Li
- WS El-Deiry
- X Shen
- X Shen
- Y Cai
- Y Wang
- Y Xiong
- Yi Sui
- Yong Cai
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.
- Author
- A Freund
- A Iannello
- A Lujambio
- AF Salem
- AN Hosein
- B Hinz
- B Hu
- B Hu
- BD Rowland
- C Del Bianco
- C Lopez-Otin
- Cathrin Brisken
- CJ Wienken
- Csaba Laszlo
- D Castel
- D Reisman
- Dania Al Labban
- DE Costea
- Dong Eun Kim
- DR Friedmann
- E Shaulian
- E Stepniak
- Elena Menietti
- F Malchers
- G Restivo
- G. Paolo Dotto
- GK Smyth
- GP Dotto
- GP Dotto
- GP Dotto
- I Martincorena
- IK Yoon
- J Bar
- J Campisi
- J Gioanni
- JE Johnson
- JG Rheinwald
- JM van Deursen
- JP Coppe
- K Boggs
- K Lefort
- K Lefort
- K Lefort
- K Polyak
- Karine Lefort
- L Hoenicke
- L Wu
- M Katoh
- M Quante
- Maria-Giuseppina Procopio
- Melody A. Swartz
- MJ Bissell
- MR Junttila
- N Erez
- NA Warfel
- NL Lill
- O Shalem
- P Chene
- Paola Ostano
- Paolo Provero
- Pino Bordignon
- R Gatenby
- R Kopan
- R Navab
- RA Weinberg
- RT Phan
- Sandro Goruppi
- Seung-Hee Jo
- T Bruno
- T Cooks
- T Kuilman
- T Riley
- TD Tlsty
- Ugo Ala
- UM Polanska
- V Devgan
- V Kolev
- Victor Neel
- W Zhou
- Witold W. Kilarski
- Wolfram Hoetzenecker
- WS el-Deiry
- WW Kilarski
- X Wu
- Y Sun
- YZ Ng
- Z Novakova
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Stromal fibroblast senescence has been linked to ageing-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAFs) are frequently increased. Loss or downmodulation of the Notch effector CSL (also known as RBP-JÎș) in dermal fibroblasts is sufficient for CAF activation and ensuing keratinocyte-derived tumours. We report that CSL silencing induces senescence of primary fibroblasts from dermis, oral mucosa, breast and lung. CSL functions in these cells as a direct repressor of multiple senescence- and CAF-effector genes. It also physically interacts with p53, repressing its activity. CSL is downmodulated in stromal fibroblasts of premalignant skin actinic keratosis lesions and squamous cell carcinomas, whereas p53 expression and function are downmodulated only in the latter, with paracrine FGF signalling as the probable culprit. Concomitant loss of CSL and p53 overcomes fibroblast senescence, enhances expression of CAF effectors and promotes stromal and cancer cell expansion. The findings support a CAF activation-stromal co-evolution model under convergent CSL-p53 control
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
- Author
- A Freund
- A Iannello
- A Lujambio
- AF Salem
- AN Hosein
- B Hinz
- B Hu
- B Hu
- BD Rowland
- C Del Bianco
- C Lopez-Otin
- Cathrin Brisken
- CJ Wienken
- Csaba Laszlo
- D Castel
- D Reisman
- Dania Al Labban
- DE Costea
- Dong Eun Kim
- DR Friedmann
- E Shaulian
- E Stepniak
- Elena Menietti
- F Malchers
- G Restivo
- G. Paolo Dotto
- GK Smyth
- GP Dotto
- GP Dotto
- GP Dotto
- I Martincorena
- IK Yoon
- J Bar
- J Campisi
- J Gioanni
- JE Johnson
- JG Rheinwald
- JM van Deursen
- JP Coppe
- K Boggs
- K Lefort
- K Lefort
- K Lefort
- K Polyak
- Karine Lefort
- L Hoenicke
- L Wu
- M Katoh
- M Quante
- Maria-Giuseppina Procopio
- Melody A. Swartz
- MJ Bissell
- MR Junttila
- N Erez
- NA Warfel
- NL Lill
- O Shalem
- P Chene
- Paola Ostano
- Paolo Provero
- Pino Bordignon
- R Gatenby
- R Kopan
- R Navab
- RA Weinberg
- RT Phan
- Sandro Goruppi
- Seung-Hee Jo
- T Bruno
- T Cooks
- T Kuilman
- T Riley
- TD Tlsty
- Ugo Ala
- UM Polanska
- V Devgan
- V Kolev
- Victor Neel
- W Zhou
- Witold W. Kilarski
- Wolfram Hoetzenecker
- WS el-Deiry
- WW Kilarski
- X Wu
- Y Sun
- YZ Ng
- Z Novakova
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
High-mobility group box 1 is a promising diagnostic and therapeutic monitoring biomarker in Cancers: A review
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2018
- Field of study