LASP SmallSat Science Data Services

We are developing of a set of turn-key science data services for smallsat data management, processing, and hosting. Using cloud computing resources and existing infrastructure, we can rapidly deploy a modular data system for a mission or project. A basic system includes reliable, secure data storage, an API for fast data access worldwide, and a lightweight website with information about the mission and data API documentation. Optional add-ons include the ability to deploy science processing software using Docker containers, interactive web-based data displays, and archive deliveries to NASA or other archive facilities. The use of AWS CloudFormation templates to build new systems makes deployment and support straightforward and cost-efficient, and provides a consistent interface for both mission teams and science data users

Electrostatic Dust Transport On Eros: 3-D Simulations Of Pond Formation

NEAR-Shoemaker spacecraft images of the surface of the near-Earth Asteroid 433 Eros reveal that more than 200 craters on Eros are partially filled with smooth deposits, termed ponds [Veverka, J., and 32 colleagues, 2001a. Science 292, 484-488]. These ponds appear smooth even at a high resolution of 1.2 cm/pixel and spectral analysis suggests that they may be made up of particles ≪50 μm in size [Robinson, M.S., Thomas, P.C., Veverka, J., Murchie, S., Carcish, B., 2001. Nature 413, 396-400; Riner, M.A., Eckart, J.M., Gigilio, J.G., Robinson, M.S., 2006. Lunar Planet. Sci. XXXVII. Abstract 2291]. Coupled with the concentration of ponds at low latitudes, the possible small particle size suggests that these deposits might be related to electrostatic transport of dust near the local terminator [Robinson, M.S., Thomas, P.C., Veverka, J., Murchie, S., Carcish, B., 2001. Nature 413, 396-400]. The work presented here incorporates the precise lighting geometry within a crater at a specified latitude into two models for electrostatic transport of dust grains in order to explore dust deposition and pond formation via this mechanism, particularly as a function of latitude. We find that micrometer-sized dust particles are preferentially transported into craters at latitudes where solar illumination angles are often low. In addition we find that if particles are electrostatically lifted off the surface they are preferentially transported into topographic depressions independent of whether the particles undergo stable levitation. The primary limiting factor for our model is uncertainty concerning the dust launching mechanism. Despite that, and though it does not match the observed north-south asymmetry in pond distribution, our model demonstrates potential for good general agreement between future predictions of pond formation via electrostatic transport of dust and observations of pond locations on the surface of Eros. © 2008 Elsevier Inc. All rights reserved

Inducible Lung Epithelial Resistance Requires Multisource Reactive Oxygen Species Generation To Protect against Viral Infections

Viral pneumonias cause profound worldwide morbidity, necessitating novel strategies to prevent and treat these potentially lethal infections. Stimulation of intrinsic lung defenses via inhalation of synergistically acting Toll-like receptor (TLR) agonists protects mice broadly against pneumonia, including otherwise-lethal viral infections, providing a potential opportunity to mitigate infectious threats. As intact lung epithelial TLR signaling is required for the inducible resistance and as these cells are the principal targets of many respiratory viruses, the capacity of lung epithelial cells to be therapeutically manipulated to function as autonomous antiviral effectors was investigated. Our work revealed that mouse and human lung epithelial cells could be stimulated to generate robust antiviral responses that both reduce viral burden and enhance survival of isolated cells and intact animals. The antiviral protection required concurrent induction of epithelial reactive oxygen species (ROS) from both mitochondrial and dual oxidase sources, although neither type I interferon enrichment nor type I interferon signaling was required for the inducible protection. Taken together, these findings establish the sufficiency of lung epithelial cells to generate therapeutically inducible antiviral responses, reveal novel antiviral roles for ROS, provide mechanistic insights into inducible resistance, and may provide an opportunity to protect patients from viral pneumonia during periods of peak vulnerability.Viruses are the most commonly identified causes of pneumonia and inflict unacceptable morbidity, despite currently available therapies. While lung epithelial cells are principal targets of respiratory viruses, they have also been recently shown to contribute importantly to therapeutically inducible antimicrobial responses. This work finds that lung cells can be stimulated to protect themselves against viral challenges, even in the absence of leukocytes, both reducing viral burden and improving survival. Further, it was found that the protection occurs via unexpected induction of reactive oxygen species (ROS) from spatially segregated sources without reliance on type I interferon signaling. Coordinated multisource ROS generation has not previously been described against viruses, nor has ROS generation been reported for epithelial cells against any pathogen. Thus, these findings extend the potential clinical applications for the strategy of inducible resistance to protect vulnerable people against viral infections and also provide new insights into the capacity of lung cells to protect against infections via novel ROS-dependent mechanisms