10,656 research outputs found

    On some key research issues in Enterprise Risk Management related to economic capital and diversification effect at group level

    Get PDF
    The goal of this short communication is to give an overview of the key research issues in Enterprise Risk Management that arose during the talks and the brainstorming session of the first ERMII research workshop, which was held at ISFA, University of Lyon in June 2007. To define and compute economic capital at group level, fundamental problems related for example to value creation, correlation and capital allocation are stated. The ideas gathered in this paper are not directly ours, we just collected and summarized the ones that arose during the workshop.

    Models of f(R) Cosmic Acceleration that Evade Solar-System Tests

    Full text link
    We study a class of metric-variation f(R) models that accelerates the expansion without a cosmological constant and satisfies both cosmological and solar-system tests in the small-field limit of the parameter space. Solar-system tests alone place only weak bounds on these models, since the additional scalar degree of freedom is locked to the high-curvature general-relativistic prediction across more than 25 orders of magnitude in density, out through the solar corona. This agreement requires that the galactic halo be of sufficient extent to maintain the galaxy at high curvature in the presence of the low-curvature cosmological background. If the galactic halo and local environment in f(R) models do not have substantially deeper potentials than expected in LCDM, then cosmological field amplitudes |f_R| > 10^{-6} will cause the galactic interior to evolve to low curvature during the acceleration epoch. Viability of large-deviation models therefore rests on the structure and evolution of the galactic halo, requiring cosmological simulations of f(R) models, and not directly on solar-system tests. Even small deviations that conservatively satisfy both galactic and solar-system constraints can still be tested by future, percent-level measurements of the linear power spectrum, while they remain undetectable to cosmological-distance measures. Although we illustrate these effects in a specific class of models, the requirements on f(R) are phrased in a nearly model-independent manner.Comment: 13 pages, 10 figures. Submitted to Phys. Rev.

    Challenges to the DGP Model from Horizon-Scale Growth and Geometry

    Full text link
    We conduct a Markov Chain Monte Carlo study of the Dvali-Gabadadze-Porrati (DGP) self-accelerating braneworld scenario given the cosmic microwave background (CMB) anisotropy, supernovae and Hubble constant data by implementing an effective dark energy prescription for modified gravity into a standard Einstein-Boltzmann code. We find no way to alleviate the tension between distance measures and horizon scale growth in this model. Growth alterations due to perturbations propagating into the bulk appear as excess CMB anisotropy at the lowest multipoles. In a flat cosmology, the maximum likelihood DGP model is nominally a 5.3 sigma poorer fit than Lambda CDM. Curvature can reduce the tension between distance measures but only at the expense of exacerbating the problem with growth leading to a 4.8 sigma result that is dominated by the low multipole CMB temperature spectrum. While changing the initial conditions to reduce large scale power can flatten the temperature spectrum, this also suppresses the large angle polarization spectrum in violation of recent results from WMAP5. The failure of this model highlights the power of combining growth and distance measures in cosmology as a test of gravity on the largest scales.Comment: 12 pages, 7 figures, 4 tables, minor revisions reflect PRD published versio

    Ebola bio-safety and laboratory testing

    Get PDF

    T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity.

    Get PDF
    BACKGROUND: Endothelial dysfunction plays a critical role in the development of type 2 diabetes (T2DM). T-cadherin (T-cad) has gained recognition as a regulator of endothelial cell (EC) function. The present study examined whether T-cad deficiency increases vascular vulnerability in T2DM. METHODS: Vascular segments were isolated from WT or T-cad knockout mice. Endothelial function, total NO accumulation, and the expression of T-cad related proteins were determined. RESULTS: Ach and acidified NaNO2 induced similar vasorelaxation in WT groups. T-cad KO mice exhibited normal response to acidified NaNO2, but manifested markedly reduced response to Ach. NO accumulation was also decreased in T-cad KO group. T-cad expression was reduced in WT mice fed 8 weeks of high fat diet (HFD). Furthermore, exacerbated reduction of vasorelaxation was observed in T-cad KO mice fed 8 weeks of HFD. CONCLUSIONS: In the current study, we provide the first in vivo evidence that T-cadherin deficiency causes endothelial dysfunction in T2DM vascular segments, suggesting the involvement of T-cad deficiency in T2DM pathogenesis

    On the origin of critical temperature enhancement in atomically-thin superconductors

    Full text link
    Recent experiments showed that thinning gallium, iron selenide and 2H tantalum disulfide to single/several monoatomic layer(s) enhances their superconducting critical temperatures. Here, we characterize these superconductors by extracting the absolute values of the London penetration depth, the superconducting energy gap, and the relative jump in specific heat at the transition temperature from their self-field critical currents. Our central finding is that the enhancement in transition temperature for these materials arises from the opening of an additional superconducting gap, while retaining a largely unchanged bulk superconducting gap. Literature data reveals that ultrathin niobium films similarly develop a second superconducting gap. Based on the available data, it seems that, for type-II superconductors, a new superconducting band appears when the film thickness becomes smaller than the out-of-plane coherence length. The same mechanism may also be the cause of enhanced interface superconductivity.Comment: 43 pages, 12 figure

    IV Regressions without Exclusion Restrictions

    Full text link
    We study identification and estimation of endogenous linear and nonlinear regression models without excluded instrumental variables, based on the standard mean independence condition and a nonlinear relevance condition. Based on the identification results, we propose two semiparametric estimators as well as a discretization-based estimator that does not require any nonparametric regressions. We establish their asymptotic normality and demonstrate via simulations their robust finite-sample performances with respect to exclusion restrictions violations and endogeneity. Our approach is applied to study the returns to education, and to test the direct effects of college proximity indicators as well as family background variables on the outcome

    Weighing Neutrinos with Galaxy Cluster Surveys

    Full text link
    Large future galaxy cluster surveys, combined with cosmic microwave background observations, can achieve a high sensitivity to the masses of cosmologically important neutrinos. We show that a weak lensing selected sample of ~100,000 clusters could tighten the current upper bound on the sum of masses of neutrino species by an order of magnitude, to a level of 0.03 eV. Since this statistical sensitivity is below the best existing lower limit on the mass of at least one neutrino species, a future detection is likely, provided that systematic errors can be controlled to a similar level.Comment: 4 pages, 1 figure, version accepted for publication in PR
    • …
    corecore