427 research outputs found

    The EU’s Global Governance Versus China’s Harmonious World

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    The EU’s ‘Global Governance’ and China’s ‘Harmonious World’ seem to be competing to be the dominant idea on international relations in the new century. After looking at the background and essence of the two theories, this paper argues that although they bear some similarities, the differences between them are substantial. The two ideas diverge on aspects such as universal values, sovereignty and the function of the nation-state. The paper then puts forward some relevant policy suggestions for both sides to get to know each other better. Finally, it suggests that it is not easy for either of them to become the single dominant theory guiding a dramatically changing world. The paper aims to focus attention and encourage debate on questions such as the possibility of the EU implementing its ‘Global Governance’ strategy –given the wide gap between developed and developing countries– and whether China’s ‘Harmonious World’ policy is a practical idea that can be accepted by the Western World

    Crack detection in a pipe by adaptive subspace iteration algorithm and least square support vector regression

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    A new combination method of beam-type finite element multiwavelet-based algorithm and least square support vector regression (LSSVR) algorithm is proposed for detecting the location and size of a crack in a pipe. According to operators of engineering problems, Rayleigh-Euler and Rayleigh-Timoshenko beam-type multiwavelets are constructed using the stable completion in the multiresolution finite element space. A rotational spring model is used for cracked pipe modeling and the local flexibility due to the crack is calculated by discrete approximation method. An adaptive subspace iteration algorithm (ASIA) is applied to efficiently approximate the exact solution of pipe model by adding new beam-type multiwavelets in each scale. To avoid the difficulty of constructing well-defined mathematical models, the normalized crack location and depth is detected by using LSSVR algorithm. The numerical and experimental results verify that the presented method can accurately identify the location and depth of crack in a pipe

    A taxonomy-based perspective of the design trade-offs for bittorrent-like protocols

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    Master'sMASTER OF SCIENC

    Contextual Dictionary Lookup for Knowledge Graph Completion

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    Knowledge graph completion (KGC) aims to solve the incompleteness of knowledge graphs (KGs) by predicting missing links from known triples, numbers of knowledge graph embedding (KGE) models have been proposed to perform KGC by learning embeddings. Nevertheless, most existing embedding models map each relation into a unique vector, overlooking the specific fine-grained semantics of them under different entities. Additionally, the few available fine-grained semantic models rely on clustering algorithms, resulting in limited performance and applicability due to the cumbersome two-stage training process. In this paper, we present a novel method utilizing contextual dictionary lookup, enabling conventional embedding models to learn fine-grained semantics of relations in an end-to-end manner. More specifically, we represent each relation using a dictionary that contains multiple latent semantics. The composition of a given entity and the dictionary's central semantics serves as the context for generating a lookup, thus determining the fine-grained semantics of the relation adaptively. The proposed loss function optimizes both the central and fine-grained semantics simultaneously to ensure their semantic consistency. Besides, we introduce two metrics to assess the validity and accuracy of the dictionary lookup operation. We extend several KGE models with the method, resulting in substantial performance improvements on widely-used benchmark datasets

    Study of imbibition in various geometries using phase field method

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    Phase field method has been widely utilized to study multiphase flow problems, but has seldom been applied to the study of imbibition. Previous methods used to simulate imbibition, such as moving mesh method, need to specify capillary pressure as a boundary condition a priori, whereas phase field method can calculate capillary pressure automatically for various geometries. Therefore, phase field method would be a versatile tool for the study of imbibition in various geometries. In this paper, phase field method is employed to solve dynamical imbibition problem in various geometries, including straight tube, conical tube and structures in which the topology changes. The variation of the imbibition height with respect to time from phase field simulation is verified with theoretical predictions from Lucas-Washburn law in a straight capillary tube with three gravitational scenarios. In addition, the capillary pressure and velocity field are found to be consistent with Laplace-Young equation and Hagen-Poiseuille equation in various geometries. The applicability and accuracy of the phase field method for the study of imbibition in structures with changing topology are also discussed.Cited as: Xiao, J., Luo, Y., Niu, M., Wang, Q., Wu, J., Liu, X., Xu, J. Study of imbibition in various geometries using phase field method. Capillarity, 2019, 2(4): 57-65, doi: 10.26804/capi.2019.04.0

    Inhibition of Proteasomal Degradation of Rpn4 Impairs Nonhomologous End-Joining Repair of DNA Double-Strand Breaks

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    BACKGROUND: The proteasome homeostasis in Saccharomyces cerevisiae is regulated by a negative feedback circuit in which the transcription factor Rpn4 induces the proteasome genes and is rapidly degraded by the assembled proteasome. The integrity of the Rpn4-proteasome feedback loop is critical for cell viability under stressed conditions. We have demonstrated that inhibition of Rpn4 degradation sensitizes cells to DNA damage, particularly in response to high doses of DNA damaging agents. The underlying mechanism, however, remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: Using yeast genetics and biochemical approach we show that inhibition of Rpn4 degradation displays a synthetic growth defect with deletion of the MEC1 checkpoint gene and sensitizes several checkpoint mutants to DNA damage. In addition, inhibition of Rpn4 degradation leads to a defect in repair of double-strand breaks (DSBs) by nonhomologous end-joining (NHEJ). The expression levels of several key NHEJ genes are downregulated and the recruitment of Yku70 to a DSB is reduced by inhibition of Rpn4 degradation. We find that Rpn4 and the proteasome are recruited to a DSB, suggesting their direct participation in NHEJ. Inhibition of Rpn4 degradation may result in a concomitant delay of release of Rpn4 and the proteasome from a DSB. CONCLUSION/SIGNIFICANCE: This study provides the first evidence for the role of proteasomal degradation of Rpn4 in NHEJ
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