N-(1-Acetyl-5-benzoyl-1,4,5,6-tetra­hydro­pyrrolo­[3,4-c]pyrazol-3-yl)benzamide

In the mol­ecule of the title compound, C21H18N4O3, the fused pyrrolo­[3,4-c]pyrazole ring system is approximately planar [maximum deviation = 0.0486 (16) Å] and forms dihedral angles of 87.21 (8) and 35.46 (7)° with the phenyl rings. In the crystal, N—H⋯O and C—H⋯O hydrogen bonds and weak C—H⋯π inter­actions link the mol­ecules into chains parallel to [201]

Noise in Genotype Selection Model

We study the steady state properties of a genotype selection model in presence of correlated Gaussian white noise. The effect of the noise on the genotype selection model is discussed. It is found that correlated noise can break the balance of gene selection and induce the phase transition which can makes us select one type gene haploid from a gene group.Comment: 8 pages, 4 figure

3-(5-Chloro­naphthalene-1-sulfonamido)-2-(2-hy­droxy­eth­yl)-4,5,6,7-tetra­hydro-2H-pyrazolo­[4,3-c]pyridin-5-ium chloride

In the cation of the title compound, C18H20ClN4O3S+·Cl−, the tetra­hydro­pyridinium ring assumes a half-chair conformation. The dihedral angle between the pyrazole ring and the naphthalene ring system is 75.19 (6)°. In the crystal, ions are linked into a three-dimensional network by N—H⋯O, N—H⋯Cl and O—H⋯Cl hydrogen bonds and weak π–π stacking inter­actions with centroid–centroid distances of 3.608 (2) Å

Evaluation of post hysterectomy vaginal cuff related complications and their management after different modes of hysterectomy

Background: Aim: To update the incidence of vaginal cuff related complications after different modes of hysterectomy and their management.Methods: The study was conducted in Jingzhou central hospital, Jingzhou, Hubei, China. Patient’s case files were reviewed who had undergone Hysterectomy from 1st Jan. 2013 - 31st Dec. 2014. The incidence of vaginal cuff related complications were retrospectively evaluated by different approaches. Data were collected according to our inclusion criteria and statistically analyzed its significance (P <0.05).Results: 887 patients underwent hysterectomy during 2 years of study period. Mean age was 54 ± 4 years. Overall incidence of vaginal cuff related complications were 34 (3.83%) which included vaginal cuff bleeding 12 (1.35%), vaginal cuff infections 16 (1.80%) and vaginal cuff dehiscence 6 (0.67%) without evisceration. Laparoscopic hysterectomy had higher incidence (6.12%), than open abdominal (2.56%) and vaginal (3.22%) hysterectomy. Incidences were significant (P = 0.032) to approaches of hysterectomy. The Incidence of vaginal cuff dehiscence between Laparoscopic and Open abdominal hysterectomy were significant (P = 0.015) but the incidence of vaginal cuff bleeding (P = 0.90) and vaginal cuff infection (P = 0.74) were not significant. Over all incidences were higher in malignancy (61%) than benign (20%).Conclusions: Study suggests that vaginal cuff bleeding, cuff infection, cuff dehiscence and evisceration are rare but not negligible which may lead into catastrophic conditions. Early diagnosis and appropriate management reduces further complications. Partial cuff dehiscence can be managed conservatively without surgical repair with satisfactory outcome

Bis[4-(2-hy­droxy­benzyl­idene­amino)­benzoato-κO 1]tetra­kis­(methanol-κO)cadmium

In the title mononuclear complex, [Cd(C14H10NO3)2(CH3OH)4], the Cd2+ cation is situated on an inversion centre. It exhibits a distorted octa­hedral coordination, defined by two carboxyl­ate O atoms from two monodentate anions and by four O atoms from four methanol mol­ecules. The crystal structure comprises intra­molecular O—H⋯O and O—H⋯N, and inter­molecular O—H⋯O hydrogen bonds. The latter help to construct a layered structure extending parallel to (100)

Current Reversals in a inhomogeneous system with asymmetric unbiased fluctuations

We present a study of transport of a Brownian particle moving in periodic symmetric potential in the presence of asymmetric unbiased fluctuations. The particle is considered to move in a medium with periodic space dependent friction. By tuning the parameters of the system, the direction of current exhibit reversals, both as a function of temperature as well as the amplitude of rocking force. We found that the mutual interplay between the opposite driving factors is the necessary term for current reversals.Comment: 9 pages, 7 figure

BrushNet: A Plug-and-Play Image Inpainting Model with Decomposed Dual-Branch Diffusion

Image inpainting, the process of restoring corrupted images, has seen significant advancements with the advent of diffusion models (DMs). Despite these advancements, current DM adaptations for inpainting, which involve modifications to the sampling strategy or the development of inpainting-specific DMs, frequently suffer from semantic inconsistencies and reduced image quality. Addressing these challenges, our work introduces a novel paradigm: the division of masked image features and noisy latent into separate branches. This division dramatically diminishes the model's learning load, facilitating a nuanced incorporation of essential masked image information in a hierarchical fashion. Herein, we present BrushNet, a novel plug-and-play dual-branch model engineered to embed pixel-level masked image features into any pre-trained DM, guaranteeing coherent and enhanced image inpainting outcomes. Additionally, we introduce BrushData and BrushBench to facilitate segmentation-based inpainting training and performance assessment. Our extensive experimental analysis demonstrates BrushNet's superior performance over existing models across seven key metrics, including image quality, mask region preservation, and textual coherence

Diaqua­bis(2-methyl-1H-imidazol-3-ium-4,5-dicarboxyl­ato-κ2 O,O′)magnesium

The title compound, [Mg(C6H5N2O4)2(H2O)2], was prepared by reaction of Mg(NO3)2 and 2-methyl-1H-imidazole-4,5-dicarboxylic acid under hydro­thermal conditions. The MgII atom lies on an inversion centre and displays a distorted octa­hedral coordination geometry. An extended three-dimensional network of inter­molecular O—H⋯O and N—H⋯O hydrogen bonds stabilizes the crystal structure

5-tert-Butyl 1-ethyl 3-amino-1,4,5,6-tetra­hydro­pyrrolo­[3,4-c]pyrazole-1,5-dicarboxyl­ate

The asymmetric unit of the title compound, C13H20N4O4, contains two crystallographically independent mol­ecules in which the dihedral angles between the fused pyrrole and pyrazole rings are 5.06 (8) and 1.12 (8)°. In the crystal, mol­ecules are linked by inter­molecular N—H⋯O and N—H⋯N hydrogen bonds into chains parallel to the b axis