Weak Measurement of Qubit Oscillations with Strong Response Detectors: Violation of the Fundamental Bound Imposed on Linear Detectors

We investigate the continuous weak measurement of a solid-state qubit by single electron transistors in nonlinear response regime. It is found that the signal-to-noise ratio can violate the universal upper bound imposed quantum mechanically to any linear response detectors. We understand the violation by means of the cross-correlation of the detector currents.Comment: 4 pages, 4 figure

Continuous weak measurement and feedback control of a solid-state charge qubit: physical unravelling of non-Lindblad master equation

Conventional quantum trajectory theory developed in quantum optics is largely based on the physical unravelling of Lindbald-type master equation, which constitutes the theoretical basis of continuous quantum measurement and feedback control. In this work, in the context of continuous quantum measurement and feedback control of a solid-state charge qubit, we present a physical unravelling scheme of non-Lindblad type master equation. Self-consistency and numerical efficiency are well demonstrated. In particular, the control effect is manifested in the detector noise spectrum, and the effect of measurement voltage is discussed.Comment: 8 pages, 5 figure

Immune modulatory roles of radioimmunotherapy: biological principles and clinical prospects

Radiation therapy (RT) not only can directly kill tumor cells by causing DNA double-strand break, but also exerts anti-tumor effects through modulating local and systemic immune responses. The immunomodulatory effects of RT are generally considered as a double-edged sword. On the one hand, RT effectively enhances the immunogenicity of tumor cells, triggers type I interferon response, induces immunogenic cell death to activate immune cell function, increases the release of proinflammatory factors, and reshapes the tumor immune microenvironment, thereby positively promoting anti-tumor immune responses. On the other hand, RT stimulates tumor cells to express immunosuppressive cytokines, upregulates the function of inhibitory immune cells, leads to lymphocytopenia and depletion of immune effector cells, and thus negatively suppresses immune responses. Nonetheless, it is notable that RT has promising abscopal effects and may achieve potent synergistic effects, especially when combined with immunotherapy in the daily clinical practice. This systematic review will provide a comprehensive profile of the latest research progress with respect to the immunomodulatory effects of RT, as well as the abscopal effect of radioimmunotherapy combinations, from the perspective of biological basis and clinical practice

Real-time counting of single electron tunneling through a T-shaped double quantum dot system

Real-time detection of single electron tunneling through a T-shaped double quantum dot is simulated, based on a Monte Carlo scheme. The double dot is embedded in a dissipative environment and the presence of electrons on the double dot is detected with a nearby quantum point contact. We demonstrate directly the bunching behavior in electron transport, which leads eventually to a super-Poissonian noise. Particularly, in the context of full counting statistics, we investigate the essential difference between the dephasing mechanisms induced by the quantum point contact detection and the coupling to the external phonon bath. A number of intriguing noise features associated with various transport mechanisms are revealed.Comment: 8 pages, 5 figure

N‑Linked Glycosylation Prevents Deamidation of Glycopeptide and Glycoprotein

Deamidation has been recognized as a common spontaneous pathway of protein degradation and a prevalent concern in the pharmaceutical industry; deamidation caused the reduction of protein/peptide drug efficacy and shelf life in several cases. More importantly, deamidation of physiological proteins is related to several human diseases and considered a timer for the diseases. N-linked glycosylation has a variety of significant biological functions, and it interestingly occurs right on the deamidation site-asparagine. It has been perceived that N-glycosylation could prevent deamidation, but experimental support is still lacking for clearly understanding the role of N-glycosylation on deamidation. Our results presented that deamidation is prevented by naturally occurring N-linked glycosylation. Glycopeptides and corresponding nonglycosylated peptides were used to compare their deamidation rates. All the nonglycosylated peptides have different half-lives ranging from one to 20 days, for the corresponding glycosylated peptides; all the results showed that the deamidation reaction was significantly reduced by the introduction of N-linked glycosylation. A glycoprotein, RNase B, also showed a significantly elongated deamidation half-life compared to nonglycosylated protein RNase A. At last, N-linked glycosylation on INGAP-P, a therapeutic peptide, increased the deamidation half-life of INGAP-P as well as its therapeutic potency

Research Progress on Mycotoxin Adsorbent and Evaluation Methods of Adsorption Effect

Chinese authorities pay high attention to food saving and loss reduction work, and emphasize to take various measures to reduce food loss. The mycotoxin pollution in grain and feed has caused food loss and seriously threatens the health of humans and livestock. The physical, chemical and biological methods can detoxify mycotoxin and improve the utilization value of feed resources. Adsorption is a detoxification method by stably combining adsorbents and mycotoxins into complexes. The multiple modification of traditional adsorbents and the development of new adsorbent materials have significantly improved the adsorption effect. This article will review the types of mycotoxin adsorbents and the evaluation methods of its adsorption effects in grain and feed. The modified methods of mycotoxin adsorbents, such as aluminosilicates, carbon materials, organic polymers, bio-adsorbents and new materials, will be briefly introduced. Besides, the application of in vitro method, artificial gastrointestinal fluid parenteral simulation and animal experiment in the evaluation of efficacy and safety of mycotoxin adsorbents will be highlighted, which can provide references for the development, scientific application and analysis of adsorption mechanisms of mycotoxin adsorbents