Finite time decoherence could be suppressed efficiently in photonic crystal

The decoherence of two initially entangled qubits in anisotropic band gap photonic crystal has been studied analytically without Born or Markovian approximation. It is shown that the decoherence dynamics of two qubits in photonic crystal is greatly different from that of two qubits in vacuum or subjected to usual non-Markovian reservoir. The results also show that the finite time decoherence invoked by spontaneous emission could be suppressed efficiently and the entanglement of the Bell state possesses odd parity is more easily preserved in photonic crystal than that of the Bell state possesses even parity under the same condition. A store scheme for entangled particle pair is proposed.Comment: 4 pages, 7 figure

破裂颅内动脉瘤的超早期血管内介入治疗

Objective: To explore the clinic significance of endovascular treatment of  ruptured intracranial aneurysms in super-early stage. Methods: Endovascular treatment of 53 cases of ruptured intracranial aneurysms,including first ruptured in 42 cases and 11 cases of ruptured twice, were performed using GDC and stent assisted GDC embolization, 29 cases in 2 days and 24 cases in more than two days after ruptured. And it was divided into the ultra-early group and the non-ultra-early group. The locations of aneurysms were as following: 20 cases in posterior communicating artery, 15 cases in anterior communicating artery, 3 cases in Ophthalmic artery, 4 cases in internal carotid artery, 6 cases in vertebral artery, and 3 cases in posterior inferior cerebellar artery; Hess-Hunt grade was as follows: 9 cases of gradeⅠ, 25 cases of grade Ⅱ,13 cases of grade Ⅲ, 6 cases of grade Ⅳ.Results:  According to the investigation among 59 aneurysms from 6 months to 60 months after operation, good recovery rate of the ultra-early group and the non-ultra-early group were respectively 96.55% and 79.17%.There was a significant difference between the two groups, and non-ultra-early group is worse, P value is less than 0.05.Conclusion: Endovascular embolization is an effective treatment for ruptured intracranial aneurysms in super-early stage.目的 探讨破裂颅内动脉瘤超早期血管内栓塞治疗的临床意义。方法 通过对53 例以自发性蛛网膜下腔出血急诊入院，包括首次破裂42例，2次破裂11例，确诊为颅内动脉瘤破裂病例采用GDC或支架辅助GDC的血管内栓塞治疗，29例于2天内、24例于2天及2天以上治疗，并分为超早期组29例和非超早期组24例。其中后交通动脉瘤20枚，前交通动脉瘤15枚，大脑中动脉瘤5枚，大脑前动脉瘤3枚，眼动脉瘤3枚，颈内动脉瘤4枚，椎动脉瘤6枚，小脑后下动脉瘤3枚；按Hess-Hunt分级：Ⅰ级9例，Ⅱ级25例，Ⅲ级13例，Ⅳ级6例。结果 随访6～60个月，超早期组和非超早期组恢复良好率分别为：96.55%，79.17%，非超早期组预后较差，两组之间比较差异有统计学意义（P＜0.05）。结论 采用超早期血管内栓塞是一种治疗破裂颅内动脉瘤的有效方法。

Two-stage flux balance analysis of metabolic networks for drug target identification

<p>Abstract</p> <p>Background</p> <p>Efficient identification of drug targets is one of major challenges for drug discovery and drug development. Traditional approaches to drug target identification include literature search-based target prioritization and <it>in vitro</it> binding assays which are both time-consuming and labor intensive. Computational integration of different knowledge sources is a more effective alternative. Wealth of omics data generated from genomic, proteomic and metabolomic techniques changes the way researchers view drug targets and provides unprecedent opportunities for drug target identification.</p> <p>Results</p> <p>In this paper, we develop a method based on flux balance analysis (FBA) of metabolic networks to identify potential drug targets. This method consists of two linear programming (LP) models, which first finds the steady optimal fluxes of reactions and the mass flows of metabolites in the pathologic state and then determines the fluxes and mass flows in the medication state with the minimal side effect caused by the medication. Drug targets are identified by comparing the fluxes of reactions in both states and examining the change of reaction fluxes. We give an illustrative example to show that the drug target identification problem can be solved effectively by our method, then apply it to a hyperuricemia-related purine metabolic pathway. Known drug targets for hyperuricemia are correctly identified by our two-stage FBA method, and the side effects of these targets are also taken into account. A number of other promising drug targets are found to be both effective and safe.</p> <p>Conclusions</p> <p>Our method is an efficient procedure for drug target identification through flux balance analysis of large-scale metabolic networks. It can generate testable predictions, provide insights into drug action mechanisms and guide experimental design of drug discovery.</p

Study on shear resistance of full-scale PC box girder reinforced by SPCCS method

Steel plate and concrete composite strengthening (SPCCS) method is developed on the basis of steel and concrete composite girder, the process of which mainly includes welding studs on the reinforcing steel plates, planting rebars in the original concrete, and casting concrete between the original structure and steel plates, thus the new and existing concrete can work together. It can improve both the bearing capacity and stiffness of bridge significantly. In order to investigate the shear resistance of concrete girder reinforced by SPCCS method, two full-scale damaged box girder released from an actual bridge are tested for contrast, one without reinforcement and the other is reinforced by SPCCS method. The shear mechanical behavior and failure mode before and after reinforcement are obtained and analyzed. Furthermore, the shear mechanism and calculation formula of shear capacity for box girder reinforced by SPCCS method are presented. The comparisons show that the calculation results are in good agreement with the test results