Product Fitness Design Based on Head and Facial Anthropometry Knowledge Management Systems

Human head facial surface changes are rich. However when designing a product to interact with people, fitness is a question that has to be considered. The accurate measurement of the size and shape of the human head and face is the key to creating a suitable product. The three-dimensional scanning method solves many problems encountered by the traditional measurement method to obtain the rich head and facial knowledge. We use the knowledge of the head and face to build the knowledge management system, thus guiding the design practice. Keywords: human factors, ergonomics, industry design, knowledge management system

A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase

Dimethylarginine dimethylaminohydrolase 1 (DDAH1) protects against cardiovascular disease by metabolising the risk factor asymmetric dimethylarginine (ADMA). However, the question whether the second DDAH isoform, DDAH2, directly metabolises ADMA has remained unanswered. Consequently, it is still unclear if DDAH2 may be a potential target for ADMA-lowering therapies or if drug development efforts should focus on DDAH2's known physiological functions in mitochondrial fission, angiogenesis, vascular remodelling, insulin secretion, and immune responses. Here, an international consortium of research groups set out to address this question using in silico, in vitro, cell culture, and murine models. The findings uniformly demonstrate that DDAH2 is incapable of metabolising ADMA, thus resolving a 20-year controversy and providing a starting point for the investigation of alternative, ADMA-independent functions of DDAH2

An Elementary Approximation of Dwell Time Algorithm for Ultra-Precision Computer-Controlled Optical Surfacing

The dwell time algorithm is one of the key technologies that determines the accuracy of a workpiece in the field of ultra-precision computer-controlled optical surfacing. Existing algorithms mainly consider meticulous mathematics theory and high convergence rates, making the computation process more uneven, and the flatness cannot be further improved. In this paper, a reasonable elementary approximation algorithm of dwell time is proposed on the basis of the theoretical requirement of a removal function in the subaperture polishing and single-peak rotational symmetry character of its practical distribution. Then, the algorithm is well discussed with theoretical analysis and numerical simulation in cases of one-dimension and two-dimensions. In contrast to conventional dwell time algorithms, this proposed algorithm transforms superposition and coupling features of the deconvolution problem into an elementary approximation issue of function value. Compared with the conventional methods, it has obvious advantages for improving calculation efficiency and flatness, and is of great significance for the efficient computation of large-aperture optical polishing. The flatness of φ150 mm and φ100 mm workpieces have achieved PVr150 = 0.028 λ and PVcr100 = 0.014 λ respectively