Investigation and Research on Physical Education and Health Curriculum of K-12 School in Guizhou Province

The purpose of this study is to investigate the current situation of physical education and health curriculum in primary and secondary schools in Guizhou Province, and to provide reference for promoting the better implementation of physical education and health curriculum in Guizhou Province. In the form of questionnaires, 1549 parents\u27 questionnaires and 254 teachers\u27 questionnaires were collected and statistically analyzed in Guizhou Province, China. Use Excel to summarize and analyze the collected questionnaires. The results found the teaching content could basically meet the needs of students. The satisfaction of primary school students, junior high school students and senior high school students with physical education and health curriculum evaluation was 71.6%, 68.4% and 63.6%, respectively. Students\u27 satisfaction with the content of physical education and health curriculum in senior high school decreased; both students and teachers believed that all students had the opportunity to participate in sports activities in physical education and health classes, but the time for skill learning and physical training in PE classes in primary and secondary schools was less than 20 minutes. The intensity of classroom exercise in 60% of primary and secondary schools was less than 75%. 94.1% of teachers control exercise load according to experience, and only 3.9% of schools use intelligent monitoring devices to monitor. 50.9% of primary and junior high school physical education classes did not meet the required number of class hours. 69.6% of the students were satisfied with the elective items in the physical education courses offered, but their satisfaction with the senior high school dropped to 61.6%. Primary and secondary schools in Guizhou Province should continue to increase the construction and investment of physical education and health curriculum venues, equipment and facilities, and optimize the use and development of existing physical education curriculum resources. Physical education teachers should constantly update teaching concepts, improve teaching methods and improve course teaching ability. Schools and teachers should carry out physical education and health courses according to the requirements of physical Education and Health Curriculum Standards, and actively promote the Chinese Health physical Education Curriculum Model put forward by JI Liu professor to ensure a certain exercise load and exercise density

Controls on preservation of organic matter during the Cenomanian Ocean Anoxic Event II (OAE2) and Turonian global sea-level rise: Agadir Basin, Morocco

The Ocean Anoxic Event II (OAE2) was a significant global event associated with a positive carbon isotope excursion, occurring from the Late Cenomanian to the Early Turonian (C/T). It has been commonly associated with enhanced organic carbon preservation. Carbon isotopic analysis carried out over the C/T interval in the Agadir Basin, Morocco, integrated with previous biostratigraphic data, allows a refined correlation of the OAE2 interval. Detailed sedimentary facies analysis identifies ten lithofacies that record the transition from shallow marine environments in the Late Cenomanian to relatively deeper conditions in the Early Turonian. The variation in lithofacies can be correlated to relative sea level changes that show a correlation to the global eustatic curve. The OAE2 interval comprises dark grey mudstones beds that display low total organic carbon (TOC) values. Trace element and facies analysis suggest dilution from high detrital influx, along with oxic water conditions and low productivity. OM-rich black mudstones are identified in post-OAE2 Early Turonian strata. Trace element analysis suggests this increase in organic matter accumulation was related to increased sea surface productivity and oxygen-depleted bottom water conditions, which facilitated organic matter preservation. Deposition of OM-rich black mudstones is widely reported during the global Early Turonian marine transgression, suggesting the very high sea level was a major control on organic matter generation and preservation

miR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes glioma growth

AbstractWe found that miR-96 is overexpressed in glioma, and its level inversely correlates with the survival of patients. The reduction in miR-96 abundance suppresses the proliferation and colony formation of glioma cells. The tumorigenicity of U-87 MG cells is reduced by miR-96 silencing. miR-96 contributes to the activation of Wnt/β-catenin pathway in glioma cells. HMG-box transcription factor 1 (HBP-1), a Wnt/β-catenin pathway inhibitor, is suppressed by miR-96. The reactivation of Wnt/β-catenin signaling causes an increase in the proliferation of glioma cells, and a decrease in miR-96 expression. On the other hand, HBP1 silencing promotes miR-96 expression. Collectively, miR-96 contributes to the progression of glioma by enhancing the activation of the Wnt/β-catenin pathway, and the miR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes the proliferation of glioma cells