The Double Burdens of Mental Health Among AIDS Patients With Fully Successful Immune Restoration: A Cross-Sectional Study of Anxiety and Depression in China

Background: Anxiety and depression continue to be significant comorbidities for people with HIV infection. We investigated the prevalence of and factors associated with anxiety and depression among adult HIV-infected patients across China.Methods: In this cross-sectional study, we described clinical and psychosocial variables related to depression and anxiety in 4103 HIV-infected persons. Doctors assessed anxiety and depression by asking patients whether they had experienced anxiety or depression in the prior month. Patients also self-administered the Hospital Anxiety and Depression (HAD) scale; those with score ≥8 on HAD-A/D were considered to be at high risk of anxiety or depression.Results: Associations between socio-demographic, psychosocial, and ART-related clinical factors and risk of depression or anxiety were investigated using multivariable logistic regression. Among patients assessed between 9/2014 and 11/2015, 27.4% had symptoms of anxiety, 32.9% had symptoms of depression, and 19.0% had both. Recentness of HIV diagnoses (P = 0.046) was associated with elevated odds of anxiety. Older age (P = 0.004), higher educational attainment (P < 0.001), employment (P = 0.001), support from family / friends (P < 0.001), and sleep disturbance (P < 0.001), and number of ART regimen switches (P = 0.046) were associated with risk of depression, while neither sex nor transmission route showed any associations. There were no significant associations with HIV-specific clinical factors including current CD4+ T cell count and current viral load.Conclusions: Prevalence of symptoms of anxiety and depression is high in this cohort of treatment-experienced HIV patients. Psychological and social-demographic factors, rather than HIV disease status, were associated with risk of depression and anxiety. This finding highlights the need to deliver interventions to address the mental health issues affecting HIV-infected persons with fully successful immune restoration across China

Simultaneous Temperature and Strain Measurements Using Polarization-Maintaining Few-Mode Bragg Gratings

Simultaneous measurement of temperature and strain was demonstrated using a polarization-maintaining few-mode Bragg grating (PM-FMF-FBG) based on the wavelength and phase modulation of the even L P 11 mode. The wavelength shift sensitivity and the interrogated phase sensitivity of the temperature and strain were measured to be 10 pm·°C−1 and 0.73 pm·με−1 and −3.2 × 10−2 rad·°C−1 and 4 × 10−4 rad·με−1, respectively, with a discrimination efficiency of 98%. The polarization interference led to selective polarization excitation of the reflection spectra, and the calculated phase sensitivity agreed with the experimental results

Sectional 2D numerical modelling method for steady state well-flow in an unconfined aquifer

Objective Both the classical Dupuit model and the modified Dupuit model including infiltration are influenced by Dupuit's assumption and have potential systematic errors. Building a numerical model of well flow in an unconfined aquifer by characterizing the three-dimensional or axisymmetric two-dimensional (2D) flow is an essential approach to verify the performance of Dupuit-type models. Methods In this study, a 2D numerical model is proposed for the steady state well-flow in an unconfined aquifer, in which the control equation of seepage in the cylindrical coordinates is transformed equivalently to the Cartesian coordinates through parameter transformation, and the sectional 2D modelling is implemented via the MODFLOW finite-difference grid of cubic blocks. In the numeric model, the water level in the pumping well is a given condition, the flux across the seepage face is estimated by difference equation according to Darcy's law, the phreatic surface is identified by the treatment of dry and wet cells in MODFLOW, and the pumping rate is determined from the water debug calculation. Results Fine grids are constructed innumerical models of typical cases to obtain high-precision results, in which the relative error of the backwards estimated pumping rate is no more than 0.2%. This numerical model is used to check the Dupuit-type well-flow models. As indicated, the groundwater level estimated from the analytical formulas generally agrees well with the numerical modelling results, except that near the well, where the analytical solution underestimates the groundwater level due to ignoring the waterjump and the errors depend on the anisotropic permeability of the aquifer. When infiltration exists, the flow in the vicinity of watershed does not follow Dupuit's assumption. However, the estimated groundwater level on the watershed by modified Dupuit well-flow equation has a low level of relative error, which is less than 1%. Conclusion This numerical method is simple and practical however it is also influenced by limitations in MODFLOW

Study of Residual Stress Compensation in Continuous Membrane Micromirrors Based on Surface Micromachining Processes

Residual stress is one of the key factors that directly determines the optical quality of micro-optical devices. With the same residual stress, the larger the aperture is, the worse the optical quality is. Therefore, continuous micromirrors are more affected by residual stress than segmented micromirrors. However, due to the complexity of boundary conditions, the influence of residual stress in segmented micromirror arrays on the device performance has been widely investigated in theory and practical applications, but only a few research results about the influence of residual stress in the continuous micromirror arrays have been reported. In this work, the residual stress both in continuous and segmented micromirror arrays is analyzed and summarized, then an accurate model for continuous micromirrors is developed. Compared with the existing models, it combines two additional factors, layer plate and point supported boundary conditions. Based on the proposed model, the change of critical stress of continuous micromirrors induced by different thicknesses of residual stress compensated membrane is theoretically investigated. Finally, the compensating experiment has been carried out, and the results show that the optical quality of micromirror can be remarkably improved, almost two orders of magnitude, with the introduction of residual stress compensation

Development of an Electrostatic Comb-Driven MEMS Scanning Mirror for Two-Dimensional Raster Scanning

Microelectromechanical System (MEMS)-based scanning mirrors are important optical devices that have been employed in many fields as a low-cost and miniaturized solution. In recent years, the rapid development of Light Detection and Ranging (LiDAR) has led to opportunities and challenges for MEMS scanners. In this work, we propose a 2D electrostatically actuated micro raster scanner with relatively large aperture. The 2D scanner combines a resonant scanning axis driven by an in-plane comb and a quasistatic scanning axis driven by a vertical comb, which is achieved by raising the moving comb finger above the fixed comb finger through the residual stress gradient. The analytic formula for the resonant axis frequency, based on the mechanical coupling of two oscillation modes, is derived and compared with finite element simulation. A prototype is designed, fabricated, and tested, and an overall optical Field-of-View (FoV) of about 60° × 4° is achieved. Finally, some possibilities for further improvement or optimization are discussed

A well flow model for a stratified heterogenous unconfined aquifer in a round island with infiltration recharge

Objective The Dupuit model of well flow is a classical steady-state well flow model for a homogeneous unconfined aquifer in a round island. However, it does not consider the widely existing infiltration recharge from precipitation, and is also inapplicable for stratified heterogeneous aquifer systems. Therefore, it must be modified to address these issues. Methods On the basis of the revised Dupuit well flow model which incorporates infiltration recharge, this study further extended its application to a stratified heterogeneous unconfined aquifer. The Girinskii's potential function was used to construct the differential equations for the radial groundwater flow according to the water balance principle, and the analytical solutions satisfying the boundary conditions are then obtained as formulas of the flow rate, water table and groundwater divide. Taking the bilayer structure as an example, typical groundwater level curves with respect to 30 scenarios of different parameter values were investigated. A special phenomenon was found in which the curves of different hydraulic conductivities intersect at a single point, which could also be proven in theory. This analytical model still adopted the Dupuit assumption and did not consider the "hydraulic jump" phenomenon on the wall of the pumping well. To check the impact of these constraints on the applicability of the analytical formulas, a two-dimensional numerical model for axially symmetric seepage was built for comparison. Results As indicated by the results, the relative error of the groundwater level estimated from the analytical solution is generally less than 4%, except for the zone near the pumping well. On the groundwater divide, where the Dupuit assumption is mostly invalid, the relative errors of the analytical solution to both the distance and height of the divide are smaller than 0.1%. Conclusion The Dupuit assumption does not significantly influence applicability of the analytical model

Assessing Numerical Simulation Methods for Reinforcement–Soil/Block Interactions in Geosynthetic-Reinforced Soil Structures

The purpose of this study is to assess effects of two different simulation methods (i.e., interfaces with a single spring-slider system and interfaces with double spring-slider systems) for interactions between reinforcement and the surrounding medium on the performances of geosynthetic-reinforced soil (GRS) structures when conducting numerical analyses. The fundamental difference between these two methods is the number of the spring-slider systems used to connect the nodes of structural elements simulating the geosynthetic reinforcement and the points of solid grids simulating the surrounding medium. Numerical simulation results of pull-out tests show that both methods reasonably predicted the pullout failure mode of the reinforcement embedded in the surrounding medium. However, the method using the interfaces with a single spring-slider system could not correctly predict the interface shear failure mode between the geosynthetics and surrounding medium. Further research shows that these two methods resulted in different predictions of the performance of GRS piers as compared with results of a laboratory load test. Numerical analyses show that a combination of interfaces with double spring-slider systems for reinforcement between facing blocks and interfaces with a single spring-slider system for reinforcement in soil resulted in the best performance prediction of the GRS structures as compared with the test results. This study also proposes and verifies an equivalent method for determining/converting the interface stiffness and strength parameters for these two methods

Temperature-Insensitive Strain Sensing Based On Few Mode Fiber

In order to solve the problem of cross sensitivity of temperature and strain that generally exits in fiber-optic sensor, the strain and temperature sensing characteristics of LP01 and LP02 mode interference based on the inter-modal interference principle of the few mode fiber are studied, and phase sensitivity theory of inter-modal interference sensing is analyzed in detail. A temperature-insensitive strain-sensing few mode fiber with core diameter of 15.1 μm, core refractive index of 1.4512 at 1550 nm and cladding refractive index of 1.444 is designed based on the numerical simulation results of the few mode fiber. The experimental system is built to research the strain and temperature sensing characteristics of few mode fiber. The results show that the theoretical calculation can predict the experimental result well. The phase sensitivity of the strain in the few mode fiber is 0.0196 rad/μm in the range of 0~600 μm, which is insensitive to the temperature in the range of 30~330℃. It can effectively improve the problem of cross-sensitive of temperature and strain

Community Structures and Antifungal Activity of Root-Associated Endophytic Actinobacteria of Healthy and Diseased Soybean

The present study was conducted to examine the influence of a pathogen Sclerotinia sclerotiorum (Lib.) de Bary on the actinobacterial community associated with the soybean roots. A total of 70 endophytic actinobacteria were isolated from the surface-sterilized roots of either healthy or diseased soybeans, and they were distributed under 14 genera. Some rare genera, including Rhodococcus, Kribbella, Glycomyces, Saccharothrix, Streptosporangium and Cellulosimicrobium, were endemic to the diseased samples, and the actinobacterial community was more diverse in the diseased samples compared with that in the heathy samples. Culture-independent analysis of root-associated actinobacterial community using the high-throughput sequencing approach also showed similar results. Four Streptomyces strains that were significantly abundant in the diseased samples exhibited strong antagonistic activity with the inhibition percentage of 54.1–87.6%. A bioactivity-guided approach was then employed to isolate and determine the chemical identity of antifungal constituents derived from the four strains. One new maremycin analogue, together with eight known compounds, were detected. All compounds showed significantly antifungal activity against S. sclerotiorum with the 50% inhibition (EC50) values of 49.14–0.21 mg/L. The higher actinobacterial diversity and more antifungal strains associated with roots of diseased plants indicate a possible role of the root-associated actinobacteria in natural defense against phytopathogens. Furthermore, these results also suggest that the root of diseased plant may be a potential reservoir of actinobacteria producing new agroactive compounds