Challenges and Countermeasures of Teachers’ Professional Development from the Perspective of Globalization

Under the influence of globalization, the intensification of international competition is in the final analysis the competition of education and talents. Teachers are the main body of teaching activities. Teachers’ professionalization is an important symbol to measure a country’s educational level. At present, the professional development of teachers in China is facing enormous challenges. In terms of concept, system and the allocation and utilization of educational resources, there are great problems. In order to meet the needs of teachers’ professional development in the perspective of globalization, the new era should promote the upgrading of teachers’ professional level from the aspects of renewal of ideas, improvement of system guarantee system, diversified development and integration and distribution of resources

Wireless coverage with disparate ranges

Coverage has been one of the most fundamental yet chal-lenging issues in wireless networks. Given a set of nodes and a set of disks of disparate radii, the problem Minimum Disk Cover seeks a disk cover of all nodes with minimum cardi-nality. We present the first polynomial time approximation scheme. We also consider a classical generalization where each input disk is associated with a positive cost, the prob-lem Min-Cost Disk Cover seeks a disk cover of all nodes with minimum total cost. We present a randomized algo-rithm that can achieve an approximation ratio of 2O(log ∗ n) with high probability, where n is the number of input disks. Another line of this work is exploring the relations be-tween disk cover and an important practical problem which seeks a wireless covering schedule of maximum life sub-ject to an energy budget function. We present two algo-rithms: Ellipsoid Algorithm (EA) and Price-Directive Al-gorithm (PDA), and prove that by applying our algorithmic results on disk cover, the approximation ratios for EA and PDA are 2O(log ∗ n) and (1 + ǫ) 2O(log ∗ n) respectively

APC Nb3_3Sn superconductors based on internal oxidation of Nb-Ta-Hf alloys

In the last few years, a new type of Nb$_3$Sn superconducting composite, containing a high density of artificial pinning centers (APC) generated via an internal oxidation approach, has demonstrated a significantly superior performance relative to present, state-of-the-art commercial Nb$_3$Sn conductors. This was achieved via the internal oxidation of Nb-4at.%Ta-1at.%Zr alloy. On the other hand, our recent studies have shown that internal oxidation of Nb-Ta-Hf alloys can also lead to dramatic improvements in Nb$_3$Sn performance. In this work we follow up this latter approach, fabricating a 61-stack APC wire based on the internal oxidation of Nb-4at.%Ta-1at.%Hf alloy, and compare its critical current density (Jc) and irreversibility field (Birr) with APC wires made using Nb-4at.%Ta-1at.%Zr. A second goal of this work was to improve the filamentary design of APC wires in order to improve their wire quality and electromagnetic stability. Our new modifications have led to significantly improved RRR and stability in the conductors, while still keeping non-Cu Jc at or above the FCC Jc specification. Further improvement via optimization of the wire recipe and design is ongoing. Finally, additional work needed to make APC conductors ready for applications in magnets is discussed.Comment: Matches published versio

Insulin reverses impaired alveolar fluid clearance in ARDS by inhibiting LPS-induced autophagy and inflammatory

Until now, acute respiratory distress syndrome (ARDS) has been a difficult clinical condition with a high mortality and morbidity rate, and is characterized by a build-up of alveolar fluid and impaired clearance. The underlying mechanism is not yet fully understood and no effective medications available. Autophagy activation is associated with ARDS caused by different pathogenic factors. It represents a new direction of prevention and treatment of ARDS to restrain autophagy to a reasonable level through pharmacological and molecular genetic methods. Na, K-ATPase is the main gradient driver of pulmonary water clearance in ARDS and could be degraded by the autophagy-lysosome pathway to affect its abundance and enzyme activity. As a normal growth hormone in human body, insulin has been widely used in clinical for a long time. To investigate the association of insulin with Na, K-ATPase, autophagy and inflammatory markers in LPS-treated C57BL/6 mice by survival assessment, proteomic analysis, histologic examination, inflammatory cell counting, myeloperoxidase, TNF-α and IL-1β activity analysis etc. This was also verified on mouse alveolar epithelial type II (AT II) and A549 cells by transmission electron microscopy. We found that insulin restored the expression of Na, K-ATPase, inhibited the activation of autophagy and reduced the release of inflammatory factors caused by alveolar epithelial damage. The regulation mechanism of insulin on Na, K-ATPase by inhibiting autophagy function may provide new drug targets for the treatment of ARDS

Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion

AbstractThousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4 is up-regulated in gastric cancer and is associated with poor prognosis. Claudin-4 reinforce proliferation, invasion, and EMT in AGS, HGC-27, and SGC-7901 cells, which could be reversed by miR-596 and miR-3620-3p. In addition, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A could act as competing endogenous RNAs to affect the function of Claudin-4. Our results suggest that non-coding RNAs play important roles in the regulatory network of Claudin-4. As such, non-coding RNAs should be considered as potential biomarkers and therapeutic targets against gastric cancer.</jats:p