FROM WECHAT TO WE FIGHT: TENCENT AND CHINA MOBILE’S DILEMMA

With the coming of mobile internet era, Giants in the different industry begin to compete face by face. This teaching case presents the event of charging for WeChat in China context to delineate the new challenges that Online Service Provider and Mobile Network Operator will face. The case describes the origin of the event, development of WeChat from inception to today, the impact of WeChat on China Mobile growth, current dilemma and disputes that all stakeholders involved. This case can help students gain more insights on the current debate around Net Neutrality

Nuclear-nuclear interaction mediated by a mechanically controlled nitrogen-vacancy-center spin in diamond

We propose a scheme to achieve nuclear-nuclear indirect interactions mediated by a mechanically driven nitrogen-vacancy (NV) center in diamond. Here we demonstrate two-qubit entangling gates and quantum-state transfer between two carbon nuclei in diamond. In such a system, the NV center interacts with a nearby nuclear spin via a dipole-dipole interaction. Under the quantum Zeno condition, the scheme is robust against decoherence caused by coupling between the NV center (nuclear spins) and the environment. Conveniently, precise control of dipole coupling is not required so this scheme is insensitive to fluctuating positions of the nuclear spins and the NV center. Our scheme provides a general blueprint for multi-nuclear-spin gates and for multi-party communication in a polygon geometry with each vertex occupied by a nuclear spin.Comment: 11 pages, 8 figure

IgG4-related disease and the current status of diagnostic approaches

IgG4-related disease is a newly recognized systemic disease characterized by involving a wide range of organs. It includes the pancreas, biliary tree, salivary glands, periorbital tissues, upper aerodigestive tract, retroperitoneum, mediastinum, aorta, soft tissue, skin, central nervous system, breast, kidneys, prostate, lungs and lymph nodes. The elevated serum titer of immunoglobulin G4 (IgG4), which is the least common (3 % to 6 %) of the 4 subclasses of IgG, is a special marker for IgG4-related disease. However, its entity is still unknown. This article reviewed the literature to learn the IgG4-related diseases and their current status of diagnostic approaches

How trade affects high-quality development through spillovers?

This paper derives the empirical estimation model from the endogenous economic growth theory, and tries to provide an effective and reasonable answer to the question ‘how trade affects high-quality development through spillovers’ from the perspective of spatial interdependence. Based on the data of 69 countries from 2000 to 2015, it is confirmed that there is an obvious spatial correlation between neighboring countries’ TFP, the TFP of geographical and economic neighboring countries shows ‘competition effect’, while the TFP of cultural neighboring countries shows ‘first spillover effect, then competition effect’. The R&D capital investment has no spatial effect on TFP of geographically or economically neighboring countries, but it has a significant ‘spillover effect’ on TFP of culturally neighboring countries. Technology spillovers caused by international trade are not only an important factor for countries to promote TFP, but also the core driving force to achieve high-quality development

Holographic Operator Product Expansion of Loop Operators in N=4\mathcal{N}=4 SO(N)SO(N) Super Yang-Mills Theory

In this paper, we compute the correlation functions of Wilson(-'t~Hooft) loops with chiral primary operators in $\mathcal{N}=4$ supersymmetric Yang-Mills theory with $SO(N)$ gauge symmetry, which has a holographic dual description of Type IIB superstring theory on the $AdS_{5}\times\mathbf{RP}^{5}$ background. Specifically, we compute the coefficients of the chiral primary operators in the operator product expansion of Wilson loops in the fundamental representation, Wilson-'t Hooft loops in the symmetric representation, Wilson loops in the anti-fundamental representation and the spinor representation. We also compare these results to the $\mathcal{N}=4$ $SU(N)$ super Yang-Mills theory.Comment: 20 pages, no figures

Germline and Somatic DNA Damage Repair Gene Mutations and Overall Survival in Metastatic Pancreatic Adenocarcinoma Patients Treated with FOLFIRINOX

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with lack of predictive biomarkers. We conducted a study to assess DNA damage repair (DDR) gene mutations as a predictive biomarker in PDAC patients treated with FOLFIRINOX. Experimental Design: Indiana University Simon Cancer Center pancreatic cancer database was used to identify patients with metastatic PDAC, treated with FOLFIRINOX and had tissue available for DNA sequencing. Baseline demographic, clinical, and pathologic information was gathered. DNA isolation and targeted sequencing was performed using the Ion AmpliSeq protocol. Overall survival (OS) analysis was conducted using Kaplan–Meier, logistic regression and Cox proportional hazard methods. Multivariate models were adjusted for age, gender, margin status, CA 19-9, adjuvant chemotherapy, tumor and nodal stage. Results: Overall, 36 patients were sequenced. DDR gene mutations were found in 12 patients. Mutations were seen in BRCA1 (N = 7), BRCA2 (N = 5), PALB2 (N = 3), MSH2 (N = 1), and FANCF (N = 1) of all the DDR genes sequenced. Median age was 65.5 years, 58% were male, 97.2% were Caucasian and 51.4% had any family history of cancer. The median OS was near significantly superior in those with DDR gene mutations present vs. absent [14 vs. 5 months; HR, 0.58; 95% confidence interval (CI), 0.29–1.14; log-rank P = 0.08]. Multivariate logistic (OR, 1.47; 95% CI, 1.04–2.06; P = 0.04) and Cox regression (HR, 0.37; 95% CI, 0.15–0.94; P = 0.04) showed presence of DDR gene mutations was associated with improved OS. Conclusions: In a single institution, retrospective study, we found that the presence of DDR gene mutations are associated with improved OS in PDAC patients treated with FOLFIRINOX