71 research outputs found
CARE: A Large Scale CT Image Dataset and Clinical Applicable Benchmark Model for Rectal Cancer Segmentation
Rectal cancer segmentation of CT image plays a crucial role in timely
clinical diagnosis, radiotherapy treatment, and follow-up. Although current
segmentation methods have shown promise in delineating cancerous tissues, they
still encounter challenges in achieving high segmentation precision. These
obstacles arise from the intricate anatomical structures of the rectum and the
difficulties in performing differential diagnosis of rectal cancer.
Additionally, a major obstacle is the lack of a large-scale, finely annotated
CT image dataset for rectal cancer segmentation. To address these issues, this
work introduces a novel large scale rectal cancer CT image dataset CARE with
pixel-level annotations for both normal and cancerous rectum, which serves as a
valuable resource for algorithm research and clinical application development.
Moreover, we propose a novel medical cancer lesion segmentation benchmark model
named U-SAM. The model is specifically designed to tackle the challenges posed
by the intricate anatomical structures of abdominal organs by incorporating
prompt information. U-SAM contains three key components: promptable information
(e.g., points) to aid in target area localization, a convolution module for
capturing low-level lesion details, and skip-connections to preserve and
recover spatial information during the encoding-decoding process. To evaluate
the effectiveness of U-SAM, we systematically compare its performance with
several popular segmentation methods on the CARE dataset. The generalization of
the model is further verified on the WORD dataset. Extensive experiments
demonstrate that the proposed U-SAM outperforms state-of-the-art methods on
these two datasets. These experiments can serve as the baseline for future
research and clinical application development.Comment: 8 page
SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres
SummarySLX4 interacts with several endonucleases to resolve structural barriers in DNA metabolism. SLX4 also interacts with telomeric protein TRF2 in human cells. The molecular mechanism of these interactions at telomeres remains unknown. Here, we report the crystal structure of the TRF2-binding motif of SLX4 (SLX4TBM) in complex with the TRFH domain of TRF2 (TRF2TRFH) and map the interactions of SLX4 with endonucleases SLX1, XPF, and MUS81. TRF2 recognizes a unique HxLxP motif on SLX4 via the peptide-binding site in its TRFH domain. Telomeric localization of SLX4 and associated nucleases depend on the SLX4-endonuclease and SLX4-TRF2 interactions and the protein levels of SLX4 and TRF2. SLX4 assembles an endonuclease toolkit that negatively regulates telomere length via SLX1-catalyzed nucleolytic resolution of telomere DNA structures. We propose that the SLX4-TRF2 complex serves as a double-layer scaffold bridging multiple endonucleases with telomeres for recombination-based telomere maintenance
Crystal structure of the Nâterminal region of human Ash2L shows a wingedâhelix motif involved in DNA binding
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102216/1/embr2011101-sup-0001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102216/2/embr2011101.reviewer_comments.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102216/3/embr2011101.pd
Two-Dimensional Wave Interaction with a Rigid Body Floating near the Marginal Ice Zone
The interaction problem of waves with a body floating near the marginal ice zone is studied, where the marginal ice zone is modeled as an array of multiple uniformly sized floating ice sheets. The linear velocity potential theory is applied for fluid flow, and the thin elastic plate mode is utilized to describe the ice sheet deflection. A hybrid method is used to solve the disturbed velocity potential; i.e., around the floating body, a boundary integral equation is established, while in the domain covered by ice sheets, the velocity potential is expanded into an eigenfunction series, and in the far-field with a free surface, a similar eigenfunction expansion is used to satisfy the radiation condition. The boundary integral equation and the coefficients of the eigenfunction expansions are solved together based on the continuous conditions of pressure and velocity on the interface between the sub-domains. Extensive results for the equivalent Youngâs modulus of the ice sheet array and hydrodynamic force on the body are provided, and the effect of individual ice sheet length as well as wave parameters are investigated in detail
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