A qualitative study of satisfaction and dissatisfaction with Jobcentre Plus; an exploration of issues identified in the 2007 Customer Satisfaction Survey with a particular focus on those most likely to be dissatisfied

This report presents the findings of qualitative research undertaken with Jobcentre Plus staff and customers to further understand the findings of the 2007 Customer Satisfaction Survey. The research took place in all 11 regions/countries between September and December 2008 and involved interviews with staff from jobcentres and Benefit Delivery Centres, and follow-up telephone interviews and focus groups with customers. The report identifies differences in the drivers of satisfaction and dissatisfaction between different benefit groups. It also explores customer satisfaction with different services and contact channels, identifies what is seen as good customer service and puts forward some suggestions for how this may be improved

Searching for the Donor Stars of ULX Pulsars

We report on our search for the optical counterparts of two ultraluminous X-ray pulsars with known orbital periods, M82 X-2 and NGC 5907 X-1, in new and archival HST observations, in an effort to characterize the donor stars in these systems. We detect five near-infrared sources consistent with the position of M82 X-2 that are too bright to be single stars. We also detect seven sources in the WFC3/UVIS F336W image whose photometry matches that of 10-15 M$_\odot$ stars turning off the main sequence. Such stars have densities consistent with the properties of the donor star of M82 X-2 as inferred from X-ray timing analysis, although it is also possible that the donor is a lower mass star below our detection limit or that there is a significant contribution from the accretion disc to the optical emission. We detect three candidate counterparts to NGC 5907 X-1 in the near-infrared. All of these are too bright to be the donor star of the ULX, which based on its orbital period is a red giant. The high background at the location of NGC 5907 X-1 precludes us from detecting this expected donor star. The recently discovered NGC 5907 ULX-2 also falls within the field of view of the near-infrared imaging; we detect four sources in the error circle, with photometry that matches AGB stars. The star suggested to be the counterpart of NGC 5907 ULX-2 by Pintore et al. (2018) falls outside our 2-$\sigma$ error circle.Comment: 10 pages, 3 figures, accepted for publication in Ap

Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution Genome evolution and evolutionary systems biology

© 2014 Janha et al.; licensee BioMed Central Ltd.Background: Cytochrome P450 CYP2C19 metabolizes a wide range of pharmacologically active substances and a relatively small number of naturally occurring environmental toxins. Poor activity alleles of CYP2C19 are very frequent worldwide, particularly in Asia, raising the possibility that reduced metabolism could be advantageous in some circumstances. The evolutionary selective forces acting on this gene have not previously been investigated. We analyzed CYP2C19 genetic markers from 127 Gambians and on 120 chromosomes from Yoruba, Europeans and Asians (Japanese + Han Chinese) in the Hapmap database. Haplotype breakdown was explored using bifurcation plots and relative extended haplotype homozygosity (REHH). Allele frequency differentiation across populations was estimated using the fixation index (FST) and haplotype diversity with coalescent models. Results: Bifurcation plots suggested conservation of alleles conferring slow metabolism (CYP2C19∗2 and ∗3). REHH was high around CYP2C19∗2 in Yoruba (REHH 8.3, at 133.3 kb from the core) and to a lesser extent in Europeans (3.5, at 37.7 kb) and Asians (2.8, at -29.7 kb). FST at the CYP2C19 locus was low overall (0.098). CYP2C19∗3 was an FST outlier in Asians (0.293), CYP2C19 haplotype diversity ST is low at the CYP2C19 locus, suggesting balancing selection overall. The biological factors responsible for these selective pressures are currently unknown. One possible explanation is that early humans were exposed to a ubiquitous novel toxin activated by CYP2C19. The genetic adaptation took place within the last 10,000 years which coincides with the development of systematic agricultural practices.This work was supported by the Medical Research Council Unit The Gambia and the European and Developing Countries Clinical Trials Partnership [grant number CG_ta_05_40204_018]

Apollo-11 lunar sample information catalogue

The Apollo 11 mission is reviewed with emphasis on the collection of lunar samples, their geologic setting, early processing, and preliminary examination. The experience gained during five subsequent missions was applied to obtain physical-chemical data for each sample using photographic and binocular microscope techniques. Topics discussed include: binocular examination procedure; breccia clast dexrriptuons, thin section examinations procedure typical breccia in thin section, typical basalt in thin section, sample histories, and chemical and age data. An index to photographs is included

A low-luminosity soft state in the short period black hole X-ray binary Swift J1753.5-0127

We present results from the spectral fitting of the candidate black hole X-ray binary Swift J1753.5-0127 in an accretion state previously unseen in this source. We fit the 0.7-78 keV spectrum with a number of models, however the preferred model is one of a multi-temperature disk with an inner disk temperature $\mathrm{k}T_\mathrm{in}=0.252\pm0.003$ keV scattered into a steep power-law with photon index $\Gamma=6.39^{+0.08}_{-0.02}$ and an additional hard power law tail ($\Gamma=1.79\pm0.02$). We report on the emergence of a strong disk-dominated component in the X-ray spectrum and we conclude that the source has entered the soft state for the first time in its ~10 year prolonged outburst. Using reasonable estimates for the distance to the source ($3$ kpc) and black hole mass ($5M_{\odot}$), we find the unabsorbed luminosity (0.1-100 keV) to be $\approx0.60$% of the Eddington luminosity, making this one of the lowest luminosity soft states recorded in X-ray binaries. We also find that the accretion disk extended towards the compact object during its transition from hard to soft, with the inner radius estimated to be $R_{\mathrm{in}}=28.0^{+0.7}_{-0.4} R_g$ or ~$12R_g$, dependent on the boundary condition chosen, assuming the above distance and mass, a spectral hardening factor $f=1.7$ and a binary inclination $i=55^{\circ}$.Comment: 10 pages, 5 figures, accepted for publication in MNRA

Spectral Changes in the Hyperluminous Pulsar in NGC 5907 as a Function of Super-Orbital Phase

We present broad-band, multi-epoch X-ray spectroscopy of the pulsating ultra-luminous X-ray source (ULX) in NGC 5907. Simultaneous XMM-Newton and NuSTAR data from 2014 are best described by a multi-color black-body model with a temperature gradient as a function of accretion disk radius significantly flatter than expected for a standard thin accretion disk (T(r) ~ r^{-p}, with p=0.608^{+0.014}_{-0.012}). Additionally, we detect a hard power-law tail at energies above 10 keV, which we interpret as being due to Comptonization. We compare this observation to archival XMM-Newton, Chandra, and NuSTAR data from 2003, 2012, and 2013, and investigate possible spectral changes as a function of phase over the 78d super-orbital period of this source. We find that observations taken around phases 0.3-0.4 show very similar temperature profiles, even though the observed flux varies significantly, while one observation taken around phase 0 has a significantly steeper profile. We discuss these findings in light of the recent discovery that the compact object is a neutron star and show that precession of the accretion disk or the neutron star can self-consistently explain most observed phenomena.Comment: 7 pages, 5 figures, submitted to ApJ; comments welcom

Broad Iron Emission from Gravitationally Lensed Quasars Observed by Chandra

Recent work has demonstrated the potential of gravitationally lensed quasars to extend measurements of black hole spin out to high-redshift with the current generation of X-ray observatories. Here we present an analysis of a large sample of 27 lensed quasars in the redshift range 1.0<z<4.5 observed with Chandra, utilizing over 1.6 Ms of total observing time, focusing on the rest-frame iron K emission from these sources. Although the X-ray signal-to-noise (S/N) currently available does not permit the detection of iron emission from the inner accretion disk in individual cases in our sample, we find significant structure in the stacked residuals. In addition to the narrow core, seen almost ubiquitously in local AGN, we find evidence for an additional underlying broad component from the inner accretion disk, with a clear red wing to the emission profile. Based on simulations, we find the detection of this broader component to be significant at greater than the 3-sigma level. This implies that iron emission from the inner disk is relatively common in the population of lensed quasars, and in turn further demonstrates that, with additional observations, this population represents an opportunity to significantly extend the sample of AGN spin measurements out to high-redshift.Comment: 5 pages, 2 figures, accepted for publication in Ap

Disentangling the Complex Broadband X-ray Spectrum of IRAS 13197-1627 with NuSTAR, XMM-Newton and Suzaku

We present results from a coordinated $XMM$-$Newton$+$NuSTAR$ observation of the type 1.8 Seyfert galaxy IRAS 13197-1627. This is a highly complex source, with strong contributions from relativistic reflection from the inner accretion disk, neutral absorption and further reprocessing by more distant material, and ionised absorption from an outflow. We undertake a detailed spectral analysis combining the broadband coverage provided by $XMM$-$Newton$+$NuSTAR$ with a multi-epoch approach incorporating archival observations performed by $XMM$-$Newton$ and $Suzaku$. Our focus is on characterising the reflection from the inner accretion disk, which previous works have suggested may dominate the AGN emission, and constraining the black hole spin. Using lamppost disk reflection models, we find that the results for the inner disk are largely insensitive to assumptions regarding the geometry of the distant reprocessor and the precise form of the illuminating X-ray continuum. However, these results do depend on the treatment of the iron abundance of the distant absorber/reprocessor. The multi-epoch data favour a scenario in which the AGN is chemically homogeneous, and we find that a rapidly rotating black hole is preferred, with $a^* \geq 0.7$, but a slowly-rotating black hole is not strongly excluded. In addition to the results for the inner disk, we also find that both the neutral and ionised absorbers vary from epoch to epoch, implying that both have some degree of inhomogeneity in their structure.Comment: 15 pages, 7 figures, accepted for publication in MNRA

Remarks on the structure constants of the Verlinde algebra associated to sl3sl_3

The structure constants $N_{\lambda, \mu}^{\mu+\nu}$ of the $sl_2$ Verlinde algebra as functions of $\mu$ either vanish or can be expressed after a change of variable as the weight function of an irreducible representation of $sl_2$. We give a similar formula in the $sl_3$ case.Comment: 5 pages, AmsTeX, 1 figure available on reques