76 research outputs found

    Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

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    Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P=9.89 × 10 -6), and rs7700147, an intergenic variant (P=2.93 × 10 -5). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes

    Gaia Early Data Release 3: acceleration of the solar system from Gaia astrometry

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    Stars and planetary system

    Gaia Data Release 3: reflectance spectra of Solar System small bodies

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    Stars and planetary system

    Gaia Data Release 3: the extragalactic content

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    Galaxie

    Gaia early data release 3: summary of the contents and survey properties (Corrigendum)

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    ERRATUMThis article is an erratum for:[https://doi.org/10.1051/0004-6361/202039657]​​​​​​​Instrumentatio

    Gaia Early Data Release 3: the Gaia catalogue of nearby stars

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    Stars and planetary system

    Gaia focused product release: radial velocity time series of long-period variables

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    Stars and planetary system

    Gaia Data Release 3: mapping the asymmetric disc of the Milky Way

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    Galaxie

    Gaia early data release 3: structure and properties of the Magellanic Clouds

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    Galaxie
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