Organizational paths of commercializing patented inventions: The effects of transaction costs, firm capabilities, and collaborative ties

This study examines the factors affecting modes of commercializing patented inventions using a novel dataset based on a survey of U.S. inventors. We find that technological uncertainty and possessing complementary assets raise the propensity for internal commercialization. We find that R&D collaboration with firms in a horizontal relationship is likely to increase the propensity to license the invention. In addition, the paper shows that macro-level environment conditions that affect exchange conditions, such as technology familiarity, influence the effects of capabilities on governance choice.transaction cost economics; knowledge-based view; collaboration ties; commercialization; innovation; patent

Protecting Their Intellectual Assets: Appropriability Conditions and Why U.S. Manufacturing Firms Patent (or Not)

Based on a survey questionnaire administered to 1478 R&D labs in the U.S. manufacturing sector in 1994, we find that firms typically protect the profits due to invention with a range of mechanisms, including patents, secrecy, lead time advantages and the use of complementary marketing and manufacturing capabilities. Of these mechanisms, however, patents tend to be the least emphasized by firms in the majority of manufacturing industries, and secrecy and lead time tend to be emphasized most heavily. A comparison of our results with the earlier survey findings of Levin et al. [1987] suggest that patents may be relied upon somewhat more heavily by larger firms now than in the early 1980s. For the protection of product innovations, secrecy now appears to be much more heavily employed across most industries than previously. Our results on the motives to patent indicate that firms patent for reasons that often extend beyond directly profiting from a patented innovation through either its commercialization or licensing. In addition to the prevention of copying, the most prominent motives for patenting include the prevention of rivals from patenting related inventions (i.e., patent blocking'), the use of patents in negotiations and the prevention of suits. We find that firms commonly patent for different reasons in discrete' product industries, such as chemicals, versus complex' product industries, such as telecommunications equipment or semiconductors. In the former, firms appear to use their patents commonly to block the development of substitutes by rivals, and in the latter, firms are much more likely to use patents to force rivals into negotiations.

Who Invents?: Evidence from the Japan-U.S. inventor survey

Human resources are increasingly seen as a key to innovation competitiveness, and there is a need for detailed, systematic data on the demographics of inventors, their motivations, and their careers. To gain systematic data on who invents, we collected detailed information on a sample of inventors in the U.S. and Japan (the RIETI-Georgia Tech inventor survey). The data come from a unique set of matched surveys of U.S. and Japanese inventors of triadic patents, i.e., patents from patent families with granted patents in the U.S. and applications filed in Japan and in the EPO, with data from over 1900 responses from the U.S. and over 3600 responses from Japan. Based on these survey data, we compare the profiles, motivations, mobility and performance of inventors in the U.S. and Japan. Overall, we find some important similarities between inventors in the U.S. and Japan. The distribution across functional affiliations within the firm, by gender, by educational fields and their motivations, are all quite similar. In particular, in both countries we find inventors emphasizing task motivations over pecuniary motivations. Firm-centered motivation (e.g., generating value for my firm) is also an important reason for inventing and this reason is relatively more important in the U.S. than Japan. Their distribution across types of organizations is quite similar. The percent of university inventors is nearly the same in the two countries, and the distribution of these inventors across technology classes is also quite similar. However, the percent from very small firms is significantly higher in the U.S. There are a few important differences. American inventors are much more likely to have a Ph.D. American inventors are older (even controlling for differences in the share of the inventors with Ph.D.s). The modal Japanese inventor has his first invention in his 20s, while for the U.S., the mode is the early 30s, and we also find many more American inventors over age 55 at the time of their triadic patent invention. In both countries, older inventors tend to produce higher value patents. American inventors are also much more mobile (although Japanese inventors with Ph.D.s also have high rates of mobility, mainly in the form of secondments). In the U.S., mobility tends to decline with age, while in Japan, mobility is higher for older inventors (likely due to the differences in retirement ages in the two countries). In both countries, mobility is associated with greater access to outside information. Finally, we find that foreign-born inventors are very important in the U.S. (we did not collect data on country of origin for Japan). Overall, these results suggest that inventor characteristics may be important for firm performance, and that institutional differences may affect the profile of inventors in each country, although the inventors of the two countries are very similar in many respects. Future work will examine how these cross-national differences in inventor profiles affect innovation in each country.

Shifting Patterns of Nitrogen Excretion and Amino Acid Catabolism Capacity during the Life Cycle of the Sea Lamprey (\u3cem\u3ePetromyzon mariunus\u3c/em\u3e)

The jawless fish, the sea lamprey (Petromyzon marinus), spends part of its life as a burrow-dwelling, suspension-feeding larva (ammocoete) before undergoing a metamorphosis into a free swimming, parasitic juvenile that feeds on the blood of fishes. We predicted that animals in this juvenile, parasitic stage have a great capacity for catabolizing amino acids when large quantities of protein-rich blood are ingested. The sixfold to 20-fold greater ammonia excretion rates (JAmm) in postmetamorphic (nonfeeding) and parasitic lampreys compared with ammocoetes suggested that basal rates of amino acid catabolism increased following metamorphosis. This was likely due to a greater basal amino acid catabolizing capacity in which there was a sixfold higher hepatic glutamate dehydrogenase (GDH) activity in parasitic lampreys compared with ammocoetes. Immunoblotting also revealed that GDH quantity was 10-fold and threefold greater in parasitic lampreys than in ammocoetes and upstream migrant lampreys, respectively. Higher hepatic alanine and aspartate aminotransferase activities in the parasitic lampreys also suggested an enhanced amino acid catabolizing capacity in this life stage. In contrast to parasitic lampreys, the twofold larger free amino acid pool in the muscle of upstream migrant lampreys confirmed that this period of natural starvation is accompanied by a prominent proteolysis. Carbamoyl phosphate synthetase III was detected at low levels in the liver of parasitic and upstream migrant lampreys, but there was no evidence of extrahepatic (muscle, intestine) urea production via the ornithine urea cycle. However, detection of arginase activity and high concentrations of arginine in the liver at all life stages examined infers that arginine hydrolysis is an important source of urea. We conclude that metamorphosis is accompanied by a metabolic reorganization that increases the capacity of parasitic sea lampreys to catabolize intermittently large amino acid loads arising from the ingestion of protein rich blood from their prey/hosts. The subsequent generation of energy-rich carbon skeletons can then be oxidized or retained for glycogen and fatty acid synthesis, which are essential fuels for the upstream migratory and spawning phases of the sea lamprey’s life cycle

How ’Open ’ is Innovation in the US and Japan?: Evidence from the RIETI-Georgia Tech inventor survey

While individual inventors are key to technological progress, it is becoming increasingly necessary for inventors and their firms to exploit information and capabilities outside the firm in order to combine onefs own resources with resources from the external environment. To better understand the collaborative process in inventions, we collected detailed information on a sample of triadic patents, focusing on the invention process, sources of ideas, and collaboration (the RIETI-Georgia Tech inventor survey), with over 1900 responses from the US and over 3600 responses from Japan. Our results suggest that in both countries, just over 10% of inventions involved an external co-inventor and about 30% involved external (non-co-inventor) collaborators (with the rate of collaboration somewhat higher in Japan). Cross-organizational co-inventions increase as firm size declines, especially in Japan. In both countries, vertical collaborations (both co-inventions and other collaborations) with users and suppliers were the most common. The most important knowledge sources were similar in the two countries: patents, customers, publications, and information from other parts of the firm, although their relative rankings varied somewhat. In particular, patent literature is a relatively more important information source in Japan and scientific literature is relatively more important in the US. Since our evidence suggest that inventors see literature globally, such difference does not seem to be driven by the difference of the disclosed literature (for an example, more early patent disclosure in Japan) as suggested by earlier literature but by that of the incentive and capability of the inventors. While in both countries most R&D funding is provided internally, venture capital and government funding play a greater role in the US than in Japan, with venture capital funds especially important for the smallest US firms. On the other hand, industry funding plays a greater role for university researchersf inventions in Japan. There is some evidence that gopen innovationh through collaborations enhances not only the technical significance of the invention, but also the probability of its commercialization through, for an example, vertical collaboration facilitating better matches between the needs of customers or the capabilities of suppliers.

Effects of Amphetamine on Striatal Dopamine Release, Open-Field Activity, and Play in Fischer 344 and Sprague–Dawley Rats

Previous work from our laboratories has shown that juvenile Fischer 344 (F344) rats are less playful than other strains and also appear to be compromised in dopamine (DA) functioning. To determine whether the dysfunctional play in this strain is associated with deficits in the handling and delivery of vesicular DA, the following experiments assessed the extent to which F344 rats are differentially sensitive to the effects of amphetamine. When exposed to amphetamine, striatal slices obtained from F344 rats showed a small increase in unstimulated DA release when compared with slices from Sprague–Dawley rats; they also showed a more rapid high K+-mediated release of DA. These data provide tentative support for the hypothesis that F344 rats have a higher concentration of cytoplasmic DA than Sprague–Dawley rats. When rats were tested for activity in an open field, F344 rats presented a pattern of results that was consistent with either an enhanced response to amphetamine (3 mg/kg) or a more rapid release of DA (10 mg/kg). Although there was some indication that amphetamine had a dose-dependent differential effect on play in the two strains, play in F344 rats was not enhanced to any degree by amphetamine. Although these results are not consistent with our working hypothesis that F344 rats are less playful because of a deficit in vesicular release of DA, they still suggest that this strain may be a useful model for better understanding the role of DA in social behavior during the juvenile period