Quantifying critical thinking: Development and validation of the Physics Lab Inventory of Critical thinking (PLIC)

Introductory physics lab instruction is undergoing a transformation, with increasing emphasis on developing experimentation and critical thinking skills. These changes present a need for standardized assessment instruments to determine the degree to which students develop these skills through instructional labs. In this article, we present the development and validation of the Physics Lab Inventory of Critical thinking (PLIC). We define critical thinking as the ability to use data and evidence to decide what to trust and what to do. The PLIC is a 10-question, closed-response assessment that probes student critical thinking skills in the context of physics experimentation. Using interviews and data from 5584 students at 29 institutions, we demonstrate, through qualitative and quantitative means, the validity and reliability of the instrument at measuring student critical thinking skills. This establishes a valuable new assessment instrument for instructional labs.Comment: 16 pages, 4 figure

Skills-focused lab instruction improves critical thinking skills and experimentation views for all students

Instructional labs are fundamental to an undergraduate physics curriculum, but their possible learning goals are vast with limited evidence to support any particular goal. In this study, we evaluate the efficacy of labs with different goals and structures on students&rsquo; critical thinking skills and views about experimentation, using an extensive database of survey responses from over 20&thinsp;000 students at over 100 institutions. Here, we show that labs focused on developing experimentation skills improve students&rsquo; critical thinking skills and experimentation views compared to labs focused on reinforcing lecture concepts. We further demonstrate the positive impacts of skills-based labs over concepts-based labs on these outcomes across students&rsquo; gender and race or ethnicity. Our analysis also shows that activities to support students&rsquo; decision making and communication explain over one-half and one-third of the effect of skills-based labs on students&rsquo; critical thinking skills and experimentation views, respectively, while modeling activities have only a small effect on performance. &nbsp;</p

Population screening for colorectal cancer means getting FIT:the past, present, and future of colorectal cancer screening using the fecal immunochemical test for hemoglobin (FIT)

Fecal immunochemical tests for hemoglobin (FIT) are changing the manner in which colorectal cancer (CRC) is screened. Although these tests are being performed worldwide, why is this test different from its predecessors? What evidence supports its adoption? How can this evidence best be used? This review addresses these questions and provides an understanding of FIT theory and practices to expedite international efforts to implement the use of FIT in CRC screening

Where are the Fossils of the First Galaxies? I. Local Volume Maps and Properties of the Undetected Dwarfs

We present a new method for generating initial conditions for LCDM N-body simulations which provides the dynamical range necessary to follow the evolution and distribution of the fossils of the first galaxies on Local Volume, 5-10 Mpc, scales. The initial distribution of particles represents the position, velocity and mass distribution of the dark and luminous halos extracted from pre-reionization simulations. We confirm previous results that ultra-faint dwarfs have properties compatible with being well preserved fossils of the first galaxies. However, because the brightest pre-reionization dwarfs form preferentially in biased regions, they most likely merge into non-fossil halos with circular velocities >20-30 km/s. Hence, we find that the maximum luminosity of true-fossils in the Milky Way is L_V<10^5 L_solar, casting doubts on the interpretation that some classical dSphs are true-fossils. In addition, we argue that most ultra-faints at small galactocentric distance, R<50 kpc, had their stellar properties modified by tides, while a large population of fossils is still undetected due to their extremely low surface brightness log(Sigma_V) < -1.4. We estimate that the region outside R_50 (~ 400 kpc) up to 1 Mpc from the Milky Way contains about a hundred true fossils of the first galaxies with V-band luminosities 10^3 - 10^5 L_solar and half-light radii, r_hl ~ 100-1000 pc.Comment: published in ApJ October 2011 with minor revisions V. 741 article ID. 1

Prion protein interacts with bace1 and differentially regulates its activity towards wild type and swedish mutant amyloid precursor protein

In Alzheimer disease amyloid-β (Aβ) peptides derived from the amyloid precursor protein (APP) accumulate in the brain. Cleavage of APP by the β-secretase BACE1 is the rate-limiting step in the production of Aβ. We have reported previously that the cellular prion protein (PrP(C)) inhibited the action of BACE1 toward human wild type APP (APP(WT)) in cellular models and that the levels of endogenous murine Aβ were significantly increased in PrP(C)-null mouse brain. Here we investigated the molecular and cellular mechanisms underlying this observation. PrP(C) interacted directly with the prodomain of the immature Golgi-localized form of BACE1. This interaction decreased BACE1 at the cell surface and in endosomes where it preferentially cleaves APP(WT) but increased it in the Golgi where it preferentially cleaves APP with the Swedish mutation (APP(Swe)). In transgenic mice expressing human APP with the Swedish and Indiana familial mutations (APP(Swe,Ind)), PrP(C) deletion had no influence on APP proteolytic processing, Aβ plaque deposition, or levels of soluble Aβ or Aβ oligomers. In cells, although PrP(C) inhibited the action of BACE1 on APP(WT), it did not inhibit BACE1 activity toward APP(Swe). The differential subcellular location of the BACE1 cleavage of APP(Swe) relative to APP(WT) provides an explanation for the failure of PrP(C) deletion to affect Aβ accumulation in APP(Swe,Ind) mice. Thus, although PrP(C) exerts no control on cleavage of APP(Swe) by BACE1, it has a profound influence on the cleavage of APP(WT), suggesting that PrP(C) may be a key protective player against sporadic Alzheimer disease

Control of wrist movement in deafferented man: evidence for a mixed strategy of position and amplitude control

© 2017 The Author(s) There is a continuing debate about control of voluntary movement, with conflicted evidence about the balance between control of movement vectors (amplitude control) that implies knowledge of the starting position for accuracy, and equilibrium point or final position control, that is independent of the starting conditions. We tested wrist flexion and extension movements in a man with a chronic peripheral neuronopathy that deprived him of proprioceptive knowledge of his wrist angles. In a series of experiments, we demonstrate that he could scale the amplitude of his wrist movements in flexion/extension, even without visual feedback, and appeared to adopt a strategy of moving via a central wrist position when asked to reach target angles from unknown start locations. When examining the relationship between positional error at the start and end of each movement in long sequences of movements, we report that he appears to have three canonical positions that he can reach relatively successfully, in flexion, in extension and in the centre. These are consistent with end-point or position control. Other positions were reached with errors that suggest amplitude control. Recording wrist flexor and extensor EMG confirmed that the flexion and extension canonical positions were reached by strong flexor and extensor activity, without antagonist activity, and other positions were reached with graded muscle activation levels. The central canonical position does not appear to be reached by either maximal co-contraction or by complete relaxation, but may have been reached by matched low-level co-contraction