Science, astronomy, and sacrifice zones: development trade-offs, and the Square Kilometre Array (SKA) radio telescope project in South Africa

We explore the notion of “sacrifice zones” to reflect critically on the trade-offs between Science & Technology (S&T) policy and inclusive development in South Africa. We draw evidence from one of the country’s flagship projects, the Square Kilometre Array (SKA) radio telescope, currently under construction in the semi-arid Northern Cape. The SKA embodies a key tension in the country’s S&T policy, that between the promotion of astronomy, based on national and global priorities (the development of science), and the advancement of local development concerns (science for development), in which the dominant assumption is that local interests are either subsumed or superseded by national and global public goods. Given the extent to which the priorities of local residents have been overlooked in the name of the greater good, we argue that a fruitful way of recasting this relationship is to regard the region around the telescope as astronomy’s terrestrial “sacrifice zone”; this opens up an important space for engaging with issues of mitigation. We conclude by raising questions about who should take responsibility for mitigating the trade-offs in policy and practice, if a more sustainable and inclusive development agenda in the areas affected by the SKA is a real concern

Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone

The ribosome is critical for all aspects of cell growth due to its essential role in protein synthesis. Paradoxically, many Ribosomal proteins (Rps) act as tumour suppressors in Drosophila and vertebrates. To examine how reductions in Rps could lead to tissue overgrowth, we took advantage of the observation that an RpS6 mutant dominantly suppresses the small rough eye phenotype in a cyclin E hypomorphic mutant (cycEJP). We demonstrated that the suppression of cycEJP by the RpS6 mutant is not a consequence of restoring CycE protein levels or activity in the eye imaginal tissue. Rather, the use of UAS-RpS6 RNAi transgenics revealed that the suppression of cycEJP is exerted via a mechanism extrinsic to the eye, whereby reduced Rp levels in the prothoracic gland decreases the activity of ecdysone, the steroid hormone, delaying developmental timing and hence allowing time for tissue and organ overgrowth. These data provide for the first time a rationale to explain the counter-intuitive organ overgrowth phenotypes observed for certain members of the Minute class of Drosophila Rp mutants. They also demonstrate how Rp mutants can affect growth and development cell non-autonomously

Unsettled : re-imagining positionality and place

12 A4 pages in pdf format. Includes bibliographical references.Inaugural address delivered by Prof Cherryl Walker on 8 May 2007

Disassembling the Square Kilometre Array: astronomy and development in South Africa

The article poses questions about astronomy and its local, national and global developmental impacts, drawing on ongoing research around the internationally networked Square Kilometre Array (SKA) radio telescope in South Africa. The relationship between progress in global science and technology and societal change has traditionally been framed through western-centric notions of progress imbued with universalism; the field of astronomy exemplifies this approach, with its assumptions of an inherently positive correlation between its science and loosely defined notions of ‘development’. We problematise this assumption through an analysis of the multiple notions of development at different scales of analysis in the SKA. We argue that large astronomy projects such as the SKA are best understood as dense assemblages of science, infrastructure, human agency and politics, in which historically rooted local concerns are marginalised in the name of the national or global public interest