A plasma inhibitor of the renin-antirenin reaction and the in vitro generation of angiotensin I

In the course of studies designed to develop a radioimmunoassay system for the detection of renin, we have identified in human plasma a potent inhibitor that interferes with the renin-antirenin reaction. Utilizing gel filtration, this renin-antirenin inhibitory activity was found to have the same molecular size as renin substrate. However, it could be separated from renin substrate by ion-exchange chromatography. When fractions containing this activity were tested in an in vitro system containing renin and renin substrate, they were found to inhibit the generation of angiotensin I.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22129/1/0000557.pd

Production and use of 6He, 7Be, 8Li, 12B and metastable nuclear beams

A low energy (few MeV/nucleon), modest flux (104-107/s) radioactive nuclear beam (RNB) facility has been in operation for approximately three years at the University of Notre Dame Van de Graaff accelerator. This facility utilizes a compact superconducting solenoid lens, designed at the University of Michigan, with adjustable apertures to produce momentum-analyzed secondary beams via the direct transfer and other methods. Useable beams of 6He, 7Be, 8Li, 12B, 18F and to our knowledge the first isomeric beam, 18mF, have been produced and a first generation of RNB experiments has been successfully completed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29368/1/0000438.pd