Enceladus' south polar sea

Author Posting. © Elsevier B.V., 2007. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Icarus 189: 72-82, doi:10.1016/j.icarus.2007.01.010.Recent observations of the south pole of Saturn’s moon Enceladus by the Cassini spacecraft have revealed an active world, powered by internal heat. In this paper, we propose that localized subsurface melting on Enceladus has produced an internal south polar sea. Evidence for this localized sea comes from the shape of Enceladus, which does not match a differentiated body at its current orbital position. We show that melting induced by the observed heat flow at the south pole produces a large enough pit to match the shape of Enceladus with a differentiated rock and ice interior. Numerical modeling of melting and ice flow shows that the sea produced beneath the south pole is stable against inflow of ductile ice from its surroundings for the duration of the heating. The shape modification due to melting also produces a negative degree-two gravity anomaly, which can reorient the spin axis of Enceladus in order to place the sea at the pole

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Co-limitation towards lower latitudes shapes global forest diversity gradients

The latitudinal diversity gradient (LDG) is one of the most recognized global patterns of species richness exhibited across a wide range of taxa. Numerous hypotheses have been proposed in the past two centuries to explain LDG, but rigorous tests of the drivers of LDGs have been limited by a lack of high-quality global species richness data. Here we produce a high-resolution (0.025° × 0.025°) map of local tree species richness using a global forest inventory database with individual tree information and local biophysical characteristics from ~1.3 million sample plots. We then quantify drivers of local tree species richness patterns across latitudes. Generally, annual mean temperature was a dominant predictor of tree species richness, which is most consistent with the metabolic theory of biodiversity (MTB). However, MTB underestimated LDG in the tropics, where high species richness was also moderated by topographic, soil and anthropogenic factors operating at local scales. Given that local landscape variables operate synergistically with bioclimatic factors in shaping the global LDG pattern, we suggest that MTB be extended to account for co-limitation by subordinate drivers

A vertically resolved model for phytoplankton aggregation

This work presents models of the vertical distribution and flux of phytoplankton aggregates, including changes with time in the distribution of aggregate sizes and sinking speeds. The distribution of sizes is described by two parameters, the mass and number of aggregates, which greatly reduces the computational cost of the models. Simple experiments demonstrate the effects of aggregation on the timing and depth distribution of primary production and export. A more detailed ecological model is applied to sites in the Arabian Sea; it demonstrates that aggregation can be important for deep sedimentation even when its effect on surface concentrations is small, and it presents the difference in timing between settlement of aggregates and fecal pellets

Neuromuscular transmitters in the horseshoe crab

We perfused neuromuscular transmitter (NMT) candidates through semi-intact legs of the horseshoe crab (Limulus polyphemus) during motor nerve stimulation, and measured claw closing strength. Glutamate and Aspartate enhanced, and GABA inhibited, contracture. But while the amino acids produced results typical of arthropod muscle, contractions were most strongly potentiated by eserine and inhibited by methyllycaconitine, which respectfully enhance and block Acetylcholine. We conclude that Acetylcholine, the vertebrate NMT, is also an endogenous excitor of Limulus muscle

Cross-fostering in Macropus eugenii leads to increased weight but not accelerated gastrointestinal maturation

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The clinical utility of alternative, less invasive sampling tehcniques in the assessment of oral hydrocortisone therapy in children and adolescents with hypopituitarism

The aim of glucocorticoid replacement therapy in ACTH-deficient patients is to mimic the normal diurnal variation of cortisol. However, current hydrocortisone (HC) replacement results in prolonged episodes of hypocortisolaemia and supraphysiological peaks. Plasma cortisol profiles are an accurate yet labour-intensive method of assessing HC replacement. Salivary and bloodspot cortisol sampling methods are less invasive and may be useful tools for assessing glucocorticoid replacement, particularly in children. Therefore, we aimed to define normal salivary and bloodspot cortisol levels in children and their correlations with the gold standard (plasma cortisol). Design: Cross-sectional study in a paediatric teaching hospital. Methods: Plasma, saliva and bloodspot cortisol profiles were performed on 30 ACTH-deficient children and 22 healthy siblings. Results: In ACTH-deficient patients taking oral HC, the bloodspot–plasma correlation (rZ0.90) was stronger than the salivary–plasma correlation (rZ0.49). Using target ranges for salivary and bloodspot cortisol levels based on normal data from control subjects, the less invasive sampling methods had low rates of agreement with plasma cortisol target ranges (saliva 65% and bloodspot 75%). Using the plasma–bloodspot correlation regression equation to convert bloodspot to calculated plasma cortisol, there was a high concordance between calculated and actual measured plasma cortisol (88%). Conclusion: Bloodspot cortisol sampling is a feasible and accurate method for monitoring oral HC replacement in paediatric patients without necessitating hospital admission, but salivary sampling is not useful