14 research outputs found
Charge Form Factor and Cluster Structure of Li Nucleus
The charge form factor of Li nucleus is considered on the basis of its
cluster structure. The charge density of Li is presented as a
superposition of two terms. One of them is a folded density and the second one
is a sum of He and the deuteron densities. Using the available
experimental data for He and deuteron charge form factors, a good
agreement of the calculations within the suggested scheme is obtained with the
experimental data for the charge form factor of Li, including those in
the region of large transferred momenta.Comment: 12 pages 5 figure
Cell Penetrating Peptides: How Do They Do It?
Cell penetrating peptides consist of short sequences of amino acids containing a large net positive charge that are able to penetrate almost any cell, carrying with them relatively large cargoes such as proteins, oligonucleotides, and drugs. During the 10Â years since their discovery, the question of how they manage to translocate across the membrane has remained unanswered. The main discussion has been centered on whether they follow an energy-independent or an energy-dependent pathway. Recently, we have discovered the possibility of an energy-independent pathway that challenges fundamental concepts associated with protein-membrane interactions (Herce and Garcia, PNAS, 104: 20805 (2007) [1]). It involves the translocation of charged residues across the hydrophobic core of the membrane and the passive diffusion of these highly charged peptides across the membrane through the formation of aqueous toroidal pores. The aim of this review is to discuss the details of the mechanism and interpret some experimental results consistent with this view