The properties of some substitute bearing alloys

A bearing is a means for supporting a load between rela-tively moving surfaces with as little friction as possible .' The plain bearings, used in the automobile , aircraft and other engineering industries, consist of two surfaces, the shaft and the hearing, generally separated by a film of lubricant. The so-called bear- ing alloys utilised for the purpose have to satisfy some primary requirements such as suitable chemical make up giving rise to a hard constituent embedded in a soft matrix , and a certain range of physical ( melting point , density, thermal conductivity, etc.) and mechanical (hardness , modulus of elasticity, tensile strength, impact resistance and age-hardening characteristics) properties. Besides these, certain service properties such as wear, seizure-resistance , conformability , embeddability corrosion-resistance, etc. are also to be complied with

Pure Cerebellar Ataxia with Homozygous Mutations in the PNPLA6 Gene

Autosomal-recessive cerebellar ataxias (ARCA) are clinically and genetically heterogeneous conditions primarily affecting the cerebellum. Mutations in the PNPLA6 gene have been identified as the cause of hereditary spastic paraplegia and complex forms of ataxia associated with retinal and endocrine manifestations in a field where the genotype-phenotype correlations are rapidly expanding. We identified two cousins from a consanguineous family belonging to a large Zoroastrian (Parsi) family residing in Mumbai, India, who presented with pure cerebellar ataxia without chorioretinal dystrophy or hypogonadotropic hypogonadism. We used a combined approach of clinical characterisation, homozygosity mapping, whole-exome and Sanger sequencing to identify the genetic defect in this family. The phenotype in the family was pure cerebellar ataxia. Homozygosity mapping revealed one large region of shared homozygosity at chromosome 19p13 between affected individuals. Within this region, whole-exome sequencing of the index case identified two novel homozygous missense variants in the PNPLA6 gene at c.3847G>A (p.V1283M) and c.3929A>T (p.D1310V) in exon 32. Both segregated perfectly with the disease in this large family, with only the two affected cousins being homozygous. We identified for the first time PNPLA6 mutations associated with pure cerebellar ataxia in a large autosomal-recessive Parsi kindred. Previous mutations in this gene have been associated with a more complex phenotype but the results here suggest an extension of the associated disease spectrum

Rolling tachyon solution of two-dimensional string theory

We consider a classical (string) field theory of $c=1$ matrix model which was developed earlier in hep-th/9207011 and subsequent papers. This is a noncommutative field theory where the noncommutativity parameter is the string coupling $g_s$. We construct a classical solution of this field theory and show that it describes the complete time history of the recently found rolling tachyon on an unstable D0 brane.Comment: 19 pages, 2 figures, minor changes in text and additional references, correction of decay time (version to appear in JHEP.

Nonperturbative effects and nonperturbative definitions in matrix models and topological strings

We develop techniques to compute multi-instanton corrections to the 1/N expansion in matrix models described by orthogonal polynomials. These techniques are based on finding trans-series solutions, i.e. formal solutions with exponentially small corrections, to the recursion relations characterizing the free energy. We illustrate this method in the Hermitian, quartic matrix model, and we provide a detailed description of the instanton corrections in the Gross-Witten-Wadia (GWW) unitary matrix model. Moreover, we use Borel resummation techniques and results from the theory of resurgent functions to relate the formal multi-instanton series to the nonperturbative definition of the matrix model. We study this relation in the case of the GWW model and its double-scaling limit, providing in this way a nice illustration of various mechanisms connecting the resummation of perturbative series to nonperturbative results, like the cancellation of nonperturbative ambiguities. Finally, we argue that trans-series solutions are also relevant in the context of topological string theory. In particular, we point out that in topological string models with both a matrix model and a large N gauge theory description, the nonperturbative, holographic definition involves a sum over the multi-instanton sectors of the matrix modelComment: 50 pages, 12 figures, comments and references added, small correction

Perinatal Bisphenol A Exposure Increases Estrogen Sensitivity of the Mammary Gland in Diverse Mouse Strains

BACKGROUND: Studies of low-dose effects of xenoestrogens have yielded conflicting results that may be attributed to differences in estrogen sensitivity between the rodent strains examined. Perinatal exposure of CD-1 mice to low doses of the xenoestrogen bisphenol A (BPA) alters peripubertal mammary gland development. Future studies to assess the role of estrogen receptors as mediators of BPA action require estrogen receptor knock-out mice that were generated on a C57Bl6 background. The sensitivity of the C57Bl6 strain to estradiol and BPA is unknown. OBJECTIVES: In the present study we examined whether the mammary glands of CD-1 and C57Bl6 mice exhibited similar responses to 17β-estradiol (E(2)) and whether perinatal exposure to BPA equally enhanced sensitivity of the mammary glands to E(2) at puberty. METHODS: Immature mice were ovariectomized and treated for 10 days with one of eight doses of E(2). Morphological mammary gland parameters were examined to identify doses producing half-maximal effects. Mice were exposed perinatally to 0 or 250 ng BPA/kg body weight (bw)/day from gestational day 8 until postnatal day (PND) 2. On PND25, female offspring were ovariectomized and given an estrogen challenge of 0, 0.5, or 1 μg E(2)/kg bw/day for 10 days. Morphometric parameters of the mammary gland were compared between strains. RESULTS: Both strains exhibited similar responses to E(2). Perinatal BPA exposure altered responses to E(2) at puberty for several parameters in both strains, although the effect in CD-1 was slightly more pronounced. CONCLUSION: Both mouse strains provide adequate models for the study of perinatal exposure to xenoestrogens

Fermions in the harmonic potential and string theory

We explicitly derive collective field theory description for the system of fermions in the harmonic potential. This field theory appears to be a coupled system of free scalar and (modified) Liouville field. This theory should be considered as an exact bosonization of the system of non-relativistic fermions in the harmonic potential. Being surprisingly similar to the world-sheet formulation of c=1 string theory, this theory has quite different physical features and it is conjectured to give space-time description of the string theory, dual to the fermions in the harmonic potential. A vertex operator in this theory is shown to be a field theoretical representation of the local fermion operator, thus describing a D0 brane in the string language. Possible generalization of this result and its derivation for the case of c=1 string theory (fermions in the inverse harmonic potential) is discussed.Comment: 29 pages, 4 figures, LaTeX2e. v2 - minor correction

Periodontal diagnosis in the context of the 2017 classification system of periodontal diseases and conditions: Presentation of a middle-aged patient with localised periodontitis

The objective of this case report is to illustrate the diagnosis and classification of periodontitis according to the 2017 classification system as recommended in the British Society of Periodontology (BSP) implementation plan. We describe a case of a patient who was diagnosed with 'localised periodontitis; stage II, grade B; currently unstable'. The present case report presents an example for the application of the new classification system and illustrates how the new classification system captures disease severity, extent and disease susceptibility by staging and grading periodontitis

Non-perturbative equivalences among large N gauge theories with adjoint and bifundamental matter fields

We prove an equivalence, in the large N limit, between certain U(N) gauge theories containing adjoint representation matter fields and their orbifold projections. Lattice regularization is used to provide a non-perturbative definition of these theories; our proof applies in the strong coupling, large mass phase of the theories. Equivalence is demonstrated by constructing and comparing the loop equations for a parent theory and its orbifold projections. Loop equations for both expectation values of single-trace observables, and for connected correlators of such observables, are considered; hence the demonstrated non-perturbative equivalence applies to the large N limits of both string tensions and particle spectra.Comment: 40 pages, JHEP styl

Geometrodynamics of spherically symmetric Lovelock gravity

We derive the Hamiltonian for spherically symmetric Lovelock gravity using the geometrodynamics approach pioneered by Kucha\v{r} in the context of four-dimensional general relativity. When written in terms of the areal radius, the generalized Misner-Sharp mass and their conjugate momenta, the generic Lovelock action and Hamiltonian take on precisely the same simple forms as in general relativity. This result supports the interpretation of Lovelock gravity as the natural higher-dimensional extension of general relativity. It also provides an important first step towards the study of the quantum mechanics, Hamiltonian thermodynamics and formation of generic Lovelock black holes.Comment: 10 pages, references and derivation details added, final version accepted by CQG (Fast Track

Effect of water deficit at different growth phases of peanut. II. Response to drought during preflowering phase

In the 1980-81 and 1981-82 post-rainy seasons, a study was conducted on a medium deep Alfisol at ICRISAT in central India, to examine the responses of groundnuts cv. Robut 33-1 to 3 levels of soil water deficit during preflowering phase relative to an adequately irrigated control. Moderate water deficits during the preflowering phase increased subsequent crop growth and pod growth rates in 1980-81 but not in 1981-82. Differences in flowering and total pod numbers between treatments were relatively small compared with the subsequent differences in pod setting and maturity. In both seasons, greater synchrony of pod set in the moderately stressed plots resulted in a greater proportion of mature pods at final harvest. The most severely stressed plot had lower yields despite adequate irrigation subsequent to the preflowering water deficit