42 research outputs found
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Structure and Morphology of Nylon 4 Chain-Folded Lamellar Crystals
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Developing ward social climate and sense of community within a high security forensic psychiatric service: Evaluating a sense of community and social climate intervention
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors
Predictive power of the DASA-IV: Variations in rating method and timescales
This project evaluated the predictive validity of the Dynamic Appraisal of
Situational Aggression – Inpatient Version (DASA-IV) in a high-secure psychiatric hospital in the
UK over 24 hours and over a single nursing shift. DASA-IV scores from three sequential nursing
shifts over a 24-hour period were compared with the mean (average of three scores across the 24-
hour period) and peak (highest of the three scores across the 24-hour period) scores across these
shifts. In addition, scores from a single nursing shift were used to predict aggressive incidents
over each of the following three shifts. The DASA-IV was completed by nursing staff during
handover meetings, rating 43 male psychiatric inpatients over a period of 6 months. Data were
compared to incident reports recorded over the same period. Receiver operating characteristic
(ROC) curves and generalized estimating equations assessed the predictive ability of various
DASA-IV scores over 24-hour and single-shift timescales. Scores from the DASA-IV based on a
single shift had moderate predictive ability for aggressive incidents occurring the next calendar
day, whereas scores based on all three shifts had excellent predictive ability. DASA-IV scores from
a single shift showed moderate predictive ability for each of the following three shifts. The DASAIV
has excellent predictive ability for aggressive incidents within a secure setting when data are
summarized over a 24-hour period, as opposed to when a single rating is taken. In addition, it has
moderate value for predicting incidents over even shorter timescales
Chemical sequence control of β-sheet assembly in macromolecular crystals of periodic polypeptides
A family of uniform periodic. polypeptides has been prepared by bacterial expression of the corresponding artificial genes, with the objective of exploring the potential for control of supramolecular organization in genetically engineered protein-based polymeric materials. The repeating units of the polypeptides consist of oligomeric alanylglycine sequences interspersed with glutamic acid residues inserted at intervals of 8 to 14 amino acids. Crystallization of such materials from formic acid produces β-sheet structures in the solid state, as shown by vibrational spectroscopy, nuclear magnetic resonance spectroscopy, and wide-angle x-ray diffraction. The diffraction results, together with observations from electron microscopy, are consistent with the formation of needle-shaped lamellar crystals whose thickness is controlled by the periodicity of the primary sequence. These results can be used to control solid-state structure in macromolecular materials