Da doença ao milagre: etnografia de soluções terapêuticas entre evangélicos na cidade de Boa Vista, Roraima

São várias as possibilidades de articulação entre doença, religião e cura. O artigo em questão constitui uma análise de narrativas sobre doença e cura pela religião, realizada a partir de abordagem etnográfica em 10 bairros de Boa Vista, Roraima, com indivíduos que afirmaram terem sido curados através de intervenção divina. Os resultados mostram que a doença não se reduz aos sintomas físicos universais da realidade empírica. Rituais mágicos de cura são, também, caminhos abertos à sua interpretação

The ICON Earth System Model Version 1.0

This work documents ICON-ESM 1.0, the first version of a coupled model based 19 on the ICON framework 20 • Performance of ICON-ESM is assessed by means of CMIP6 DECK experiments 21 at standard CMIP-type resolution 22 • ICON-ESM reproduces the observed temperature evolution. Biases in clouds, winds, 23 sea-ice, and ocean properties are larger than in MPI-ESM. Abstract 25 This work documents the ICON-Earth System Model (ICON-ESM V1.0), the first cou-26 pled model based on the ICON (ICOsahedral Non-hydrostatic) framework with its un-27 structured, icosahedral grid concept. The ICON-A atmosphere uses a nonhydrostatic dy-28 namical core and the ocean model ICON-O builds on the same ICON infrastructure, but 29 applies the Boussinesq and hydrostatic approximation and includes a sea-ice model. The 30 ICON-Land module provides a new framework for the modelling of land processes and 31 the terrestrial carbon cycle. The oceanic carbon cycle and biogeochemistry are repre-32 sented by the Hamburg Ocean Carbon Cycle module. We describe the tuning and spin-33 up of a base-line version at a resolution typical for models participating in the Coupled 34 Model Intercomparison Project (CMIP). The performance of ICON-ESM is assessed by 35 means of a set of standard CMIP6 simulations. Achievements are well-balanced top-of-36 atmosphere radiation, stable key climate quantities in the control simulation, and a good 37 representation of the historical surface temperature evolution. The model has overall bi-38 ases, which are comparable to those of other CMIP models, but ICON-ESM performs 39 less well than its predecessor, the Max Planck Institute Earth System Model. Problem-40 atic biases are diagnosed in ICON-ESM in the vertical cloud distribution and the mean 41 zonal wind field. In the ocean, sub-surface temperature and salinity biases are of con-42 cern as is a too strong seasonal cycle of the sea-ice cover in both hemispheres. ICON-43 ESM V1.0 serves as a basis for further developments that will take advantage of ICON-44 specific properties such as spatially varying resolution, and configurations at very high 45 resolution. 46 Plain Language Summary 47 ICON-ESM is a completely new coupled climate and earth system model that ap-48 plies novel design principles and numerical techniques. The atmosphere model applies 49 a non-hydrostatic dynamical core, both atmosphere and ocean models apply unstruc-50 tured meshes, and the model is adapted for high-performance computing systems. This 51 article describes how the component models for atmosphere, land, and ocean are cou-52 pled together and how we achieve a stable climate by setting certain tuning parameters 53 and performing sensitivity experiments. We evaluate the performance of our new model 54 by running a set of experiments under pre-industrial and historical climate conditions 55 as well as a set of idealized greenhouse-gas-increase experiments. These experiments were 56 designed by the Coupled Model Intercomparison Project (CMIP) and allow us to com-57 pare the results to those from other CMIP models and the predecessor of our model, the 58 Max Planck Institute for Meteorology Earth System Model. While we diagnose overall 59 satisfactory performance, we find that ICON-ESM features somewhat larger biases in 60 several quantities compared to its predecessor at comparable grid resolution. We empha-61 size that the present configuration serves as a basis from where future development steps 62 will open up new perspectives in earth system modellin

Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

Chimeric antigen receptor (CAR) T cell therapies have resulted in profound clinical responses in the treatment of CD19-positive hematological malignancies, but a significant proportion of patients do not respond or relapse eventually. As an alternative to CAR T cells, T cells can be engineered to express a tumor-targeting T cell receptor (TCR). Due to HLA restriction of TCRs, CARs have emerged as a preferred treatment moiety when targeting surface antigens, despite the fact that functional differences between engineered TCR (eTCR) T and CAR T cells remain ill-defined. Here, we compared the activity of CAR T cells versus engineered TCR T cells in targeting the B cell malignancy-associated antigen CD20 as a function of antigen exposure. We found CAR T cells to be more potent effector cells, producing higher levels of cytokines and killing more efficiently than eTCR T cells in a short time frame. However, we revealed that the increase of antigen exposure significantly impaired CAR T cell expansion, a phenotype defined by high expression of coinhibitory molecules and effector differentiation. In contrast, eTCR T cells expanded better than CAR T cells under high antigenic pressure, with lower expression of coinhibitory molecules and maintenance of an early differentiation phenotype, and comparable clearance of tumor cells

Efeitos tecnológicos e estruturais nas emissões brasileiras de CO2 para o período 2000 a 2005: uma abordagem de análise de decomposição estrutural (SDA)

Este artigo objetiva mensurar a influência de mudanças na estrutura produtiva sobre as variações nas emissões de dióxido de carbono brasileiras. O método utilizado foi o de análise de decomposição estrutural (SDA - Structural Decomposition Analysis). Trata-se de um método de insumo-produto, logo de estática comparativa, que permite detalhar as mudanças tanto tecnológicas quanto no processo produtivo em termos setoriais. As emissões setoriais foram obtidas junto ao balanço de emissões, energias equivalente e final, e as matrizes IBGE de insumo-produto são provenientes do Sistema de Contas Nacionais do IBGE, ambas para os anos de 2000 e 2005, sendo adaptadas para 15 setores econômicos brasileiros. Os principais resultados indicam que: os setores de transportes, siderurgia e alimentos e bebidas são aqueles que se mostraram mais propensos ao aumento de emissões quando considerada a variação na demanda final, enquanto os setores indústria do cimento, de minerais não metálicos e papel e celulose se destacam por redução de emissões devido à mudança tecnológica

Ergebnisse der Ortsdosismessungen mit Filmdosimetern.

In medical X ray departments, industrial facilities and nuclear reactors, local radiation was measured with film dosimeters in more than 1700 different places. These were fixed over a period of about 30 days in different spots in the rooms controlled. The measurements obtained are classified into different groups. The advantage of film dosimeters compared with usual measurements of the dose rates is the fact that they give an average of the real dose over a long period of time at low cost. The results obtained are of interest for radioprotection technique

Die Strahlengefahr -  Realistisch gesehen.

It is evident that ionizing radiation at high doses is able to damage living organisms and may induce cancer and leukemia in man. At low doses, however, biopositive effects appear possible too, for which examples are given. The mechanism of such effects can be explained as a general stimulation of the natural immune system. In conclusion, radiation at low doses is thus not as dangerous as often assumed but is rather essential for life and the maintenance of health

Dosiseinsparung in der Röntgendiagnostik.

It is quantitatively demonstrated how in the radiological diagnosis in fluoroscopy and radiograms the dose to the patient can be reduced by means of new methods, i.e. by image intensifier and television. The 'receiver' and the 'transmitter' are studied, and it is determined how far the choice of an appropriately hard and sufficiently filtered radiation may reduce the dose. The influence of the focus skin distance is described and it is explained that the new high power generators and tubes can also reduce the dose. Natural limits, of course, are put to the reduction of patient dose by quantum noise